The evolution of antibiotic susceptibility and resistance during the formation of Escherichia colibiofilms in the absence of antibiotics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Jabus G Tyerman, José M Ponciano, Paul Joyce, Larry J Forney, Luke J Harmon

ABSTRACT

BACKGROUND: Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes. RESULTS: Using Escherichia coli biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic selection. CONCLUSIONS: Our results demonstrate the rapid de novo evolution of heritable variation in antibiotic sensitivity and resistance during E. coli biofilm development. We suggest that evolutionary processes, whether genetic drift or natural selection, should be considered as a factor to explain the elevated tolerance to antibiotics typically observed in bacterial biofilms. This could be an under-appreciated mechanism that accounts why biofilm populations are, in general, highly resistant to antibiotic treatment. More... »

PAGES

22

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2148-13-22

DOI

http://dx.doi.org/10.1186/1471-2148-13-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049916067

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23356665


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