Microarray analysis of a salamander hopeful monster reveals transcriptional signatures of paedomorphic brain development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Robert B Page, Meredith A Boley, Jeramiah J Smith, Srikrishna Putta, Stephen R Voss

ABSTRACT

BACKGROUND: The Mexican axolotl (Ambystoma mexicanum) is considered a hopeful monster because it exhibits an adaptive and derived mode of development - paedomorphosis - that has evolved rapidly and independently among tiger salamanders. Unlike related tiger salamanders that undergo metamorphosis, axolotls retain larval morphological traits into adulthood and thus present an adult body plan that differs dramatically from the ancestral (metamorphic) form. The basis of paedomorphic development was investigated by comparing temporal patterns of gene transcription between axolotl and tiger salamander larvae (Ambystoma tigrinum tigrinum) that typically undergo a metamorphosis. RESULTS: Transcript abundances from whole brain and pituitary were estimated via microarray analysis on four different days post hatching (42, 56, 70, 84 dph) and regression modeling was used to independently identify genes that were differentially expressed as a function of time in both species. Collectively, more differentially expressed genes (DEGs) were identified as unique to the axolotl (n = 76) and tiger salamander (n = 292) than were identified as shared (n = 108). All but two of the shared DEGs exhibited the same temporal pattern of expression and the unique genes tended to show greater changes later in the larval period when tiger salamander larvae were undergoing anatomical metamorphosis. A second, complementary analysis that directly compared the expression of 1320 genes between the species identified 409 genes that differed as a function of species or the interaction between time and species. Of these 409 DEGs, 84% exhibited higher abundances in tiger salamander larvae at all sampling times. CONCLUSIONS: Many of the unique tiger salamander transcriptional responses are probably associated with metamorphic biological processes. However, the axolotl also showed unique patterns of transcription early in development. In particular, the axolotl showed a genome-wide reduction in mRNA abundance across loci, including genes that regulate hypothalamic-pituitary activities. This suggests that an axolotls failure to undergo anatomical metamorphosis late in the larval period is indirectly associated with a mechanism(s) that acts earlier in development to broadly program transcription. The axolotl hopeful monster provides a model to identify mechanisms of early brain development that proximally and ultimately affect the expression of adult phenotypes. More... »

PAGES

199

References to SciGraph publications

  • 1982. Change in Developmental Timing As a Mechanism of Macroevolution in EVOLUTION AND DEVELOPMENT
  • 2003-05. DAVID: Database for Annotation, Visualization, and Integrated Discovery in GENOME BIOLOGY
  • 2005-12. Sal-Site: Integrating new and existing ambystomatid salamander research and informational resources in BMC GENOMICS
  • 2006-12. Effects of filtering by Present call on analysis of microarray experiments in BMC BIOINFORMATICS
  • 1920-01. Metamorphosis of Axolotl caused by Thyroid-feeding in NATURE
  • 2005-12. Quadratic regression analysis for gene discovery and pattern recognition for non-cyclic short time-course microarray experiments in BMC BIOINFORMATICS
  • 2008-12. Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma) in BMC GENOMICS
  • 2006-03. The proper place of hopeful monsters in evolutionary biology in THEORY IN BIOSCIENCES
  • 2003-09. DAVID: Database for Annotation, Visualization, and Integrated Discovery in GENOME BIOLOGY
  • 1997-04. The evolution of apical dominance in maize in NATURE
  • 2003-02. Evolution of gene expression in the Drosophila melanogaster subgroup in NATURE GENETICS
  • 1903-02. <i>The Mexican Axolotl</i> in NATURE
  • 2009-03. Saltational evolution: hopeful monsters are here to stay in THEORY IN BIOSCIENCES
  • 2005. Quality Assessment of Affymetrix GeneChip Data in BIOINFORMATICS AND COMPUTATIONAL BIOLOGY SOLUTIONS USING R AND BIOCONDUCTOR
  • 2005. Preprocessing High-density Oligonucleotide Arrays in BIOINFORMATICS AND COMPUTATIONAL BIOLOGY SOLUTIONS USING R AND BIOCONDUCTOR
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2148-10-199

    DOI

    http://dx.doi.org/10.1186/1471-2148-10-199

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005076799

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20584293


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ambystoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ambystoma mexicanum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Comparative Genomic Hybridization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Developmental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Larva", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metamorphosis, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Kentucky", 
              "id": "https://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Page", 
            "givenName": "Robert B", 
            "id": "sg:person.0616022734.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616022734.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kentucky", 
              "id": "https://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boley", 
            "givenName": "Meredith A", 
            "id": "sg:person.01301165633.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301165633.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virginia Mason Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.416879.5", 
              "name": [
                "Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA", 
                "Benaroya Research Institute, 98101, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Jeramiah J", 
            "id": "sg:person.01220430766.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220430766.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kentucky", 
              "id": "https://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Putta", 
            "givenName": "Srikrishna", 
            "id": "sg:person.011003024747.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003024747.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Kentucky", 
              "id": "https://www.grid.ac/institutes/grid.266539.d", 
              "name": [
                "Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voss", 
            "givenName": "Stephen R", 
            "id": "sg:person.0765737215.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765737215.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1471-2164-9-78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000350520", 
              "https://doi.org/10.1186/1471-2164-9-78"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.00609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002074310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygcen.2009.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002858789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.950150404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004933565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/104435b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005299705", 
              "https://doi.org/10.1038/104435b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005603731", 
              "https://doi.org/10.1038/ng1086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005603731", 
              "https://doi.org/10.1038/ng1086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-6-106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005711302", 
              "https://doi.org/10.1186/1471-2105-6-106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-6-106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005711302", 
              "https://doi.org/10.1186/1471-2105-6-106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.21.11910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012140380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.thbio.2005.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012646804", 
              "https://doi.org/10.1016/j.thbio.2005.11.002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.25.14185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014177462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0308479101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014636573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/067330b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014917718", 
              "https://doi.org/10.1038/067330b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/067330b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014917718", 
              "https://doi.org/10.1038/067330b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-6480(92)90172-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015971106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.5.10.1739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016020940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2008.05670.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021003931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2003-4-5-p3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021292424", 
              "https://doi.org/10.1186/gb-2003-4-5-p3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-294x.2000.01025.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-6-181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023659272", 
              "https://doi.org/10.1186/1471-2164-6-181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.06.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024541944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-387-29362-0_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024889327", 
              "https://doi.org/10.1007/0-387-29362-0_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-45532-2_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025512307", 
              "https://doi.org/10.1007/978-3-642-45532-2_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12064-009-0058-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028686480", 
              "https://doi.org/10.1007/s12064-009-0058-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029813401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.9.e45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-387-29362-0_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030857081", 
              "https://doi.org/10.1007/0-387-29362-0_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0171-2985(00)80049-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032331626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpc.2006.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033927262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037543114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-7-49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039973931", 
              "https://doi.org/10.1186/1471-2105-7-49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0012-1606(74)90268-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040123745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04344.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040991805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2008-0056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041191234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2003-4-9-r60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041539408", 
              "https://doi.org/10.1186/gb-2003-4-9-r60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/icb/36.1.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041671341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.104.038273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043211215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.104.038273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043211215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-294x.2003.01806.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044415464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2008.07.067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044839890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.020685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049187290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/386485a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050653323", 
              "https://doi.org/10.1038/386485a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/icb/18.2.313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059652297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1126121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062453672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2005-0322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074544770", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076883946", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082984602", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.jhered.a111618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083620593"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-12", 
        "datePublishedReg": "2010-12-01", 
        "description": "BACKGROUND: The Mexican axolotl (Ambystoma mexicanum) is considered a hopeful monster because it exhibits an adaptive and derived mode of development - paedomorphosis - that has evolved rapidly and independently among tiger salamanders. Unlike related tiger salamanders that undergo metamorphosis, axolotls retain larval morphological traits into adulthood and thus present an adult body plan that differs dramatically from the ancestral (metamorphic) form. The basis of paedomorphic development was investigated by comparing temporal patterns of gene transcription between axolotl and tiger salamander larvae (Ambystoma tigrinum tigrinum) that typically undergo a metamorphosis.\nRESULTS: Transcript abundances from whole brain and pituitary were estimated via microarray analysis on four different days post hatching (42, 56, 70, 84 dph) and regression modeling was used to independently identify genes that were differentially expressed as a function of time in both species. Collectively, more differentially expressed genes (DEGs) were identified as unique to the axolotl (n = 76) and tiger salamander (n = 292) than were identified as shared (n = 108). All but two of the shared DEGs exhibited the same temporal pattern of expression and the unique genes tended to show greater changes later in the larval period when tiger salamander larvae were undergoing anatomical metamorphosis. A second, complementary analysis that directly compared the expression of 1320 genes between the species identified 409 genes that differed as a function of species or the interaction between time and species. Of these 409 DEGs, 84% exhibited higher abundances in tiger salamander larvae at all sampling times.\nCONCLUSIONS: Many of the unique tiger salamander transcriptional responses are probably associated with metamorphic biological processes. However, the axolotl also showed unique patterns of transcription early in development. In particular, the axolotl showed a genome-wide reduction in mRNA abundance across loci, including genes that regulate hypothalamic-pituitary activities. This suggests that an axolotls failure to undergo anatomical metamorphosis late in the larval period is indirectly associated with a mechanism(s) that acts earlier in development to broadly program transcription. The axolotl hopeful monster provides a model to identify mechanisms of early brain development that proximally and ultimately affect the expression of adult phenotypes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2148-10-199", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3053646", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2622149", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024249", 
            "issn": [
              "1471-2148"
            ], 
            "name": "BMC Evolutionary Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Microarray analysis of a salamander hopeful monster reveals transcriptional signatures of paedomorphic brain development", 
        "pagination": "199", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "18304824a3732a5eb9751d449e7c9e8d537d9e47db03c7250f4896c2a60c6fb8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20584293"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100966975"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2148-10-199"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1005076799"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2148-10-199", 
          "https://app.dimensions.ai/details/publication/pub.1005076799"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000549.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1471-2148-10-199"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-199'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-199'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-199'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-199'


     

    This table displays all metadata directly associated to this object as RDF triples.

    302 TRIPLES      21 PREDICATES      87 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2148-10-199 schema:about N049a3c134ef8450b9a9e587bec64e749
    2 N1a8fd5313351419bad53081ae548e3ae
    3 N1aee545560b34edc8a7e3a217a25fc25
    4 N5030ba29070046c4ab85c3f78a606af9
    5 N6f461d475a2d4f88a07aef12b83aba77
    6 N794b517b0b814ec3a323c1cab2342813
    7 N8ad0ddde8dd443a584b9cb180672154f
    8 N981e50b49b234584bf194cf9cb0f3989
    9 Nb43ff4a874a64e5c8368c209ad3e38ba
    10 Nb5cf02641b4640958c75f100ab158f91
    11 Nb5e675a58f1143a2ac71049fcc3d9f83
    12 Ne6ea713e3be842058c1e4489e5f698ae
    13 anzsrc-for:06
    14 anzsrc-for:0604
    15 schema:author Nf3be46c98cae4e1db03e9086eea73ee4
    16 schema:citation sg:pub.10.1007/0-387-29362-0_2
    17 sg:pub.10.1007/0-387-29362-0_3
    18 sg:pub.10.1007/978-3-642-45532-2_16
    19 sg:pub.10.1007/s12064-009-0058-z
    20 sg:pub.10.1016/j.thbio.2005.11.002
    21 sg:pub.10.1038/067330b0
    22 sg:pub.10.1038/104435b0
    23 sg:pub.10.1038/386485a0
    24 sg:pub.10.1038/ng1086
    25 sg:pub.10.1186/1471-2105-6-106
    26 sg:pub.10.1186/1471-2105-7-49
    27 sg:pub.10.1186/1471-2164-6-181
    28 sg:pub.10.1186/1471-2164-9-78
    29 sg:pub.10.1186/gb-2003-4-5-p3
    30 sg:pub.10.1186/gb-2003-4-9-r60
    31 https://app.dimensions.ai/details/publication/pub.1074544770
    32 https://app.dimensions.ai/details/publication/pub.1076883946
    33 https://app.dimensions.ai/details/publication/pub.1082984602
    34 https://doi.org/10.1002/bies.950150404
    35 https://doi.org/10.1016/0012-1606(74)90268-1
    36 https://doi.org/10.1016/0016-6480(92)90172-g
    37 https://doi.org/10.1016/j.brainres.2008.07.067
    38 https://doi.org/10.1016/j.cbpc.2006.06.003
    39 https://doi.org/10.1016/j.neuroscience.2008.06.022
    40 https://doi.org/10.1016/j.ygcen.2009.03.001
    41 https://doi.org/10.1016/s0171-2985(00)80049-2
    42 https://doi.org/10.1046/j.1365-294x.2000.01025.x
    43 https://doi.org/10.1046/j.1365-294x.2003.01806.x
    44 https://doi.org/10.1073/pnas.0308479101
    45 https://doi.org/10.1073/pnas.94.25.14185
    46 https://doi.org/10.1073/pnas.96.21.11910
    47 https://doi.org/10.1093/bioinformatics/btl056
    48 https://doi.org/10.1093/biostatistics/4.2.249
    49 https://doi.org/10.1093/icb/18.2.313
    50 https://doi.org/10.1093/icb/36.1.24
    51 https://doi.org/10.1093/nar/29.9.e45
    52 https://doi.org/10.1093/oxfordjournals.jhered.a111618
    53 https://doi.org/10.1101/gad.5.10.1739
    54 https://doi.org/10.1111/j.1471-4159.2006.04344.x
    55 https://doi.org/10.1111/j.1471-4159.2008.05670.x
    56 https://doi.org/10.1126/science.1126121
    57 https://doi.org/10.1210/jc.2005-0322
    58 https://doi.org/10.1242/dev.00609
    59 https://doi.org/10.1242/dev.020685
    60 https://doi.org/10.1534/genetics.104.038273
    61 https://doi.org/10.1634/stemcells.2008-0056
    62 schema:datePublished 2010-12
    63 schema:datePublishedReg 2010-12-01
    64 schema:description BACKGROUND: The Mexican axolotl (Ambystoma mexicanum) is considered a hopeful monster because it exhibits an adaptive and derived mode of development - paedomorphosis - that has evolved rapidly and independently among tiger salamanders. Unlike related tiger salamanders that undergo metamorphosis, axolotls retain larval morphological traits into adulthood and thus present an adult body plan that differs dramatically from the ancestral (metamorphic) form. The basis of paedomorphic development was investigated by comparing temporal patterns of gene transcription between axolotl and tiger salamander larvae (Ambystoma tigrinum tigrinum) that typically undergo a metamorphosis. RESULTS: Transcript abundances from whole brain and pituitary were estimated via microarray analysis on four different days post hatching (42, 56, 70, 84 dph) and regression modeling was used to independently identify genes that were differentially expressed as a function of time in both species. Collectively, more differentially expressed genes (DEGs) were identified as unique to the axolotl (n = 76) and tiger salamander (n = 292) than were identified as shared (n = 108). All but two of the shared DEGs exhibited the same temporal pattern of expression and the unique genes tended to show greater changes later in the larval period when tiger salamander larvae were undergoing anatomical metamorphosis. A second, complementary analysis that directly compared the expression of 1320 genes between the species identified 409 genes that differed as a function of species or the interaction between time and species. Of these 409 DEGs, 84% exhibited higher abundances in tiger salamander larvae at all sampling times. CONCLUSIONS: Many of the unique tiger salamander transcriptional responses are probably associated with metamorphic biological processes. However, the axolotl also showed unique patterns of transcription early in development. In particular, the axolotl showed a genome-wide reduction in mRNA abundance across loci, including genes that regulate hypothalamic-pituitary activities. This suggests that an axolotls failure to undergo anatomical metamorphosis late in the larval period is indirectly associated with a mechanism(s) that acts earlier in development to broadly program transcription. The axolotl hopeful monster provides a model to identify mechanisms of early brain development that proximally and ultimately affect the expression of adult phenotypes.
    65 schema:genre research_article
    66 schema:inLanguage en
    67 schema:isAccessibleForFree true
    68 schema:isPartOf Na802ee798618405e908f36f2a57db2b4
    69 Nadea86dc3fdc4be78536659353f19e32
    70 sg:journal.1024249
    71 schema:name Microarray analysis of a salamander hopeful monster reveals transcriptional signatures of paedomorphic brain development
    72 schema:pagination 199
    73 schema:productId N009759ca3f524395afa5079ee5b86c47
    74 N6aa4dda4f41d4c41adf7af5caa45687b
    75 N6ffd87df9e0e43aa8ead36e7eafbe648
    76 N87b6f9fab8b54929ab11839370466d85
    77 Nb7139238e6874117b9090871c9f0f9dc
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005076799
    79 https://doi.org/10.1186/1471-2148-10-199
    80 schema:sdDatePublished 2019-04-10T13:24
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher N87e31de60e7f4384a6ac795b9feb5fe3
    83 schema:url http://link.springer.com/10.1186%2F1471-2148-10-199
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N009759ca3f524395afa5079ee5b86c47 schema:name pubmed_id
    88 schema:value 20584293
    89 rdf:type schema:PropertyValue
    90 N049a3c134ef8450b9a9e587bec64e749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Ambystoma
    92 rdf:type schema:DefinedTerm
    93 N098941318a1d414abcd048fafbbdd170 rdf:first sg:person.01220430766.48
    94 rdf:rest N6e99f4a9a2c448ab9a01fc6315a77188
    95 N1a8fd5313351419bad53081ae548e3ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Animals
    97 rdf:type schema:DefinedTerm
    98 N1aee545560b34edc8a7e3a217a25fc25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Ambystoma mexicanum
    100 rdf:type schema:DefinedTerm
    101 N5030ba29070046c4ab85c3f78a606af9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Larva
    103 rdf:type schema:DefinedTerm
    104 N6aa4dda4f41d4c41adf7af5caa45687b schema:name doi
    105 schema:value 10.1186/1471-2148-10-199
    106 rdf:type schema:PropertyValue
    107 N6e99f4a9a2c448ab9a01fc6315a77188 rdf:first sg:person.011003024747.64
    108 rdf:rest N7a0cd73d256147a9a4e5fe6b0bef87df
    109 N6f461d475a2d4f88a07aef12b83aba77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Comparative Genomic Hybridization
    111 rdf:type schema:DefinedTerm
    112 N6ffd87df9e0e43aa8ead36e7eafbe648 schema:name readcube_id
    113 schema:value 18304824a3732a5eb9751d449e7c9e8d537d9e47db03c7250f4896c2a60c6fb8
    114 rdf:type schema:PropertyValue
    115 N794b517b0b814ec3a323c1cab2342813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Oligonucleotide Array Sequence Analysis
    117 rdf:type schema:DefinedTerm
    118 N7950abb39bd14132a423d17ef8c5340b rdf:first sg:person.01301165633.12
    119 rdf:rest N098941318a1d414abcd048fafbbdd170
    120 N7a0cd73d256147a9a4e5fe6b0bef87df rdf:first sg:person.0765737215.86
    121 rdf:rest rdf:nil
    122 N87b6f9fab8b54929ab11839370466d85 schema:name nlm_unique_id
    123 schema:value 100966975
    124 rdf:type schema:PropertyValue
    125 N87e31de60e7f4384a6ac795b9feb5fe3 schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N8ad0ddde8dd443a584b9cb180672154f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Transcription, Genetic
    129 rdf:type schema:DefinedTerm
    130 N981e50b49b234584bf194cf9cb0f3989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Metamorphosis, Biological
    132 rdf:type schema:DefinedTerm
    133 Na802ee798618405e908f36f2a57db2b4 schema:issueNumber 1
    134 rdf:type schema:PublicationIssue
    135 Nadea86dc3fdc4be78536659353f19e32 schema:volumeNumber 10
    136 rdf:type schema:PublicationVolume
    137 Nb43ff4a874a64e5c8368c209ad3e38ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Gene Expression Regulation, Developmental
    139 rdf:type schema:DefinedTerm
    140 Nb5cf02641b4640958c75f100ab158f91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Gene Expression Profiling
    142 rdf:type schema:DefinedTerm
    143 Nb5e675a58f1143a2ac71049fcc3d9f83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Brain
    145 rdf:type schema:DefinedTerm
    146 Nb7139238e6874117b9090871c9f0f9dc schema:name dimensions_id
    147 schema:value pub.1005076799
    148 rdf:type schema:PropertyValue
    149 Ne6ea713e3be842058c1e4489e5f698ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name RNA, Messenger
    151 rdf:type schema:DefinedTerm
    152 Nf3be46c98cae4e1db03e9086eea73ee4 rdf:first sg:person.0616022734.20
    153 rdf:rest N7950abb39bd14132a423d17ef8c5340b
    154 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Biological Sciences
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Genetics
    159 rdf:type schema:DefinedTerm
    160 sg:grant.2622149 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2148-10-199
    161 rdf:type schema:MonetaryGrant
    162 sg:grant.3053646 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2148-10-199
    163 rdf:type schema:MonetaryGrant
    164 sg:journal.1024249 schema:issn 1471-2148
    165 schema:name BMC Evolutionary Biology
    166 rdf:type schema:Periodical
    167 sg:person.011003024747.64 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
    168 schema:familyName Putta
    169 schema:givenName Srikrishna
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003024747.64
    171 rdf:type schema:Person
    172 sg:person.01220430766.48 schema:affiliation https://www.grid.ac/institutes/grid.416879.5
    173 schema:familyName Smith
    174 schema:givenName Jeramiah J
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220430766.48
    176 rdf:type schema:Person
    177 sg:person.01301165633.12 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
    178 schema:familyName Boley
    179 schema:givenName Meredith A
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301165633.12
    181 rdf:type schema:Person
    182 sg:person.0616022734.20 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
    183 schema:familyName Page
    184 schema:givenName Robert B
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616022734.20
    186 rdf:type schema:Person
    187 sg:person.0765737215.86 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
    188 schema:familyName Voss
    189 schema:givenName Stephen R
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765737215.86
    191 rdf:type schema:Person
    192 sg:pub.10.1007/0-387-29362-0_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030857081
    193 https://doi.org/10.1007/0-387-29362-0_2
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/0-387-29362-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024889327
    196 https://doi.org/10.1007/0-387-29362-0_3
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/978-3-642-45532-2_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025512307
    199 https://doi.org/10.1007/978-3-642-45532-2_16
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s12064-009-0058-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028686480
    202 https://doi.org/10.1007/s12064-009-0058-z
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1016/j.thbio.2005.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012646804
    205 https://doi.org/10.1016/j.thbio.2005.11.002
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/067330b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014917718
    208 https://doi.org/10.1038/067330b0
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/104435b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005299705
    211 https://doi.org/10.1038/104435b0
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/386485a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050653323
    214 https://doi.org/10.1038/386485a0
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/ng1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005603731
    217 https://doi.org/10.1038/ng1086
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1186/1471-2105-6-106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005711302
    220 https://doi.org/10.1186/1471-2105-6-106
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1186/1471-2105-7-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039973931
    223 https://doi.org/10.1186/1471-2105-7-49
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1186/1471-2164-6-181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023659272
    226 https://doi.org/10.1186/1471-2164-6-181
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1186/1471-2164-9-78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000350520
    229 https://doi.org/10.1186/1471-2164-9-78
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1186/gb-2003-4-5-p3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021292424
    232 https://doi.org/10.1186/gb-2003-4-5-p3
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1186/gb-2003-4-9-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041539408
    235 https://doi.org/10.1186/gb-2003-4-9-r60
    236 rdf:type schema:CreativeWork
    237 https://app.dimensions.ai/details/publication/pub.1074544770 schema:CreativeWork
    238 https://app.dimensions.ai/details/publication/pub.1076883946 schema:CreativeWork
    239 https://app.dimensions.ai/details/publication/pub.1082984602 schema:CreativeWork
    240 https://doi.org/10.1002/bies.950150404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004933565
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/0012-1606(74)90268-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040123745
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/0016-6480(92)90172-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1015971106
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.brainres.2008.07.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044839890
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.cbpc.2006.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033927262
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.neuroscience.2008.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024541944
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.ygcen.2009.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002858789
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0171-2985(00)80049-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032331626
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1046/j.1365-294x.2000.01025.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762048
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1046/j.1365-294x.2003.01806.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044415464
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1073/pnas.0308479101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014636573
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1073/pnas.94.25.14185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014177462
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1073/pnas.96.21.11910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012140380
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1093/bioinformatics/btl056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813401
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1093/icb/18.2.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059652297
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1093/icb/36.1.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041671341
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1093/oxfordjournals.jhered.a111618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083620593
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1101/gad.5.10.1739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016020940
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1111/j.1471-4159.2006.04344.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040991805
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1111/j.1471-4159.2008.05670.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021003931
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1126/science.1126121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453672
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1210/jc.2005-0322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288369
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1242/dev.00609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002074310
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1242/dev.020685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049187290
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1534/genetics.104.038273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043211215
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1634/stemcells.2008-0056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041191234
    295 rdf:type schema:CreativeWork
    296 https://www.grid.ac/institutes/grid.266539.d schema:alternateName University of Kentucky
    297 schema:name Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA
    298 rdf:type schema:Organization
    299 https://www.grid.ac/institutes/grid.416879.5 schema:alternateName Virginia Mason Medical Center
    300 schema:name Benaroya Research Institute, 98101, Seattle, WA, USA
    301 Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, 40506, Lexington, KY, USA
    302 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...