Positive selection of HIV host factors and the evolution of lentivirus genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Katarzyna Bożek, Thomas Lengauer

ABSTRACT

BACKGROUND: Positive selection of host proteins that interact with pathogens can indicate factors relevant for infection and potentially be a measure of pathogen driven evolution. RESULTS: Our analysis of 1439 primate genes and 175 lentivirus genomes points to specific host factors of high genetic variability that could account for differences in susceptibility to disease and indicate specific mechanisms of host defense and pathogen adaptation. We find that the largest amount of genetic change occurs in genes coding for cellular membrane proteins of the host as well as in the viral envelope genes suggesting cell entry and immune evasion as the primary evolutionary interface between host and pathogen. We additionally detect the innate immune response as a gene functional group harboring large differences among primates that could potentially account for the different levels of immune activation in the HIV/SIV primate infection. We find a significant correlation between the evolutionary rates of interacting host and viral proteins pointing to processes of the host-pathogen biology that are relatively conserved among species and to those undergoing accelerated genetic evolution. CONCLUSIONS: These results indicate specific host factors and their functional groups experiencing pathogen driven evolutionary selection pressures. Individual host factors pointed to by our analysis might merit further study as potential targets of antiretroviral therapies. More... »

PAGES

186

References to SciGraph publications

  • 1989-06. An African primate lentivirus (SIVsmclosely related to HIV-2 in NATURE
  • 2000-05. Gene Ontology: tool for the unification of biology in NATURE GENETICS
  • 1999-02. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes in NATURE
  • 2002-12. Biological and biomedical implications of the co-evolution of pathogens and their hosts in NATURE GENETICS
  • 2007-12. BEAST: Bayesian evolutionary analysis by sampling trees in BMC EVOLUTIONARY BIOLOGY
  • 2007-10-18. Genome-wide detection and characterization of positive selection in human populations in NATURE
  • 1992-08. Human infection by genetically diverse SIVSM-related HIV-2 in West Africa in NATURE
  • 2002-08. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein in NATURE
  • 1996-06. Identification of a major co-receptor for primary isolates of HIV-1 in NATURE
  • 2008-07. Interferon-inducible antiviral effectors in NATURE REVIEWS IMMUNOLOGY
  • 2008-08. Innate immune modulation by RNA viruses: emerging insights from functional genomics in NATURE REVIEWS IMMUNOLOGY
  • 2009-07. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz in NATURE
  • 2008-10. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections in NATURE MEDICINE
  • 2004-02. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys in NATURE
  • 2008-01. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2148-10-186

    DOI

    http://dx.doi.org/10.1186/1471-2148-10-186

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017181005

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20565842


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bayes Theorem", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Comparative Genomic Hybridization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Evolution, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Host-Pathogen Interactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immune Evasion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phylogeny", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Primates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Selection, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "env Gene Products, Human Immunodeficiency Virus", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Informatics", 
              "id": "https://www.grid.ac/institutes/grid.419528.3", 
              "name": [
                "Max Planck Institute for Informatics Computational Biology and Applied Algorithmics, Campus E1 4, 66123, Saarbr\u00c3\u00bccken, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bo\u017cek", 
            "givenName": "Katarzyna", 
            "id": "sg:person.01253301327.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253301327.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Informatics", 
              "id": "https://www.grid.ac/institutes/grid.419528.3", 
              "name": [
                "Max Planck Institute for Informatics Computational Biology and Applied Algorithmics, Campus E1 4, 66123, Saarbr\u00c3\u00bccken, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lengauer", 
            "givenName": "Thomas", 
            "id": "sg:person.01360543616.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360543616.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1182/blood-2003-08-2928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000815920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.74.7.3105-3111.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003046335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2008.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003348718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003559067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.04.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004216542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2008.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007701750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/aid.2008.0113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008173980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.14.4813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008456364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2004.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008830963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009228613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msi097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009754204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2148-7-214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010584451", 
              "https://doi.org/10.1186/1471-2148-7-214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.molbev.a025575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010735164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012721182", 
              "https://doi.org/10.1038/nature00939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012721182", 
              "https://doi.org/10.1038/nature00939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/339389a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014105555", 
              "https://doi.org/10.1038/339389a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/339389a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014105555", 
              "https://doi.org/10.1038/339389a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0020275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014347029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.molbev.a025629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014813751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.0040032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016470445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1152725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017813843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.17.1.657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018153442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019249723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019300068", 
              "https://doi.org/10.1038/nm.1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019644195", 
              "https://doi.org/10.1038/nature08200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019644195", 
              "https://doi.org/10.1038/nature08200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msm088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020427894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/17130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021010829", 
              "https://doi.org/10.1038/17130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/17130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021010829", 
              "https://doi.org/10.1038/17130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-199406000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021275417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-199406000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021275417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0684.2005.00122.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021473929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0684.2005.00122.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021473929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1000107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021716150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.77.7.4070-4080.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023812525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024668704", 
              "https://doi.org/10.1038/nri2314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1000300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025276191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025846396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1000437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026806356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026942564", 
              "https://doi.org/10.1038/nri2377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1933104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028112195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0409853102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030254365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0040072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030948598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0040072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030948598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031314486", 
              "https://doi.org/10.1038/nature02343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031314486", 
              "https://doi.org/10.1038/nature02343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1000377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033121588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.07.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033459273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033741877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.00854-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035412361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/viro.1996.0458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036405340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036876479", 
              "https://doi.org/10.1038/nature06250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/o06-143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037009600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/095632020501600601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037232074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/095632020501600601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037232074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307713101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038227904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msp197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038735790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msp197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038735790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddh183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039101786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1000429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039498707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.11.4835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039812025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200112)31:12<3513::aid-immu3513>3.0.co;2-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040351407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.006221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042261931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/358495a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043363104", 
              "https://doi.org/10.1038/358495a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.76.13.6841-6844.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047644569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmv.21486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047693885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmv.21486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047693885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2009.03.521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047698606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.77.22.12299-12309.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047700604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1202-569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050075068", 
              "https://doi.org/10.1038/ng1202-569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1202-569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050075068", 
              "https://doi.org/10.1038/ng1202-569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1202-569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050075068", 
              "https://doi.org/10.1038/ng1202-569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.molbev.a026236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050352635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-199509040-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050558220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-199509040-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050558220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050660540", 
              "https://doi.org/10.1038/nature06553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90688-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050830960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90571-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052667845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1239303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052744398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/381661a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053562821", 
              "https://doi.org/10.1038/381661a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/aid.1992.8.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059223481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1123016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062453415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8235615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074718098", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082586007", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082619619", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082862586", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083245096", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083249090", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-12", 
        "datePublishedReg": "2010-12-01", 
        "description": "BACKGROUND: Positive selection of host proteins that interact with pathogens can indicate factors relevant for infection and potentially be a measure of pathogen driven evolution.\nRESULTS: Our analysis of 1439 primate genes and 175 lentivirus genomes points to specific host factors of high genetic variability that could account for differences in susceptibility to disease and indicate specific mechanisms of host defense and pathogen adaptation. We find that the largest amount of genetic change occurs in genes coding for cellular membrane proteins of the host as well as in the viral envelope genes suggesting cell entry and immune evasion as the primary evolutionary interface between host and pathogen. We additionally detect the innate immune response as a gene functional group harboring large differences among primates that could potentially account for the different levels of immune activation in the HIV/SIV primate infection. We find a significant correlation between the evolutionary rates of interacting host and viral proteins pointing to processes of the host-pathogen biology that are relatively conserved among species and to those undergoing accelerated genetic evolution.\nCONCLUSIONS: These results indicate specific host factors and their functional groups experiencing pathogen driven evolutionary selection pressures. Individual host factors pointed to by our analysis might merit further study as potential targets of antiretroviral therapies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2148-10-186", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024249", 
            "issn": [
              "1471-2148"
            ], 
            "name": "BMC Evolutionary Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Positive selection of HIV host factors and the evolution of lentivirus genes", 
        "pagination": "186", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "51db502d505317f079ee19e5d8522bf13ac4f8228ef9c5877d9d9c36f33a2230"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20565842"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100966975"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2148-10-186"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017181005"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2148-10-186", 
          "https://app.dimensions.ai/details/publication/pub.1017181005"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000504.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1471-2148-10-186"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-186'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-186'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-186'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2148-10-186'


     

    This table displays all metadata directly associated to this object as RDF triples.

    380 TRIPLES      21 PREDICATES      122 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2148-10-186 schema:about N0910a8a679904fad9c3a910459764f27
    2 N1cdbec321e0d4ab888428f642e9f6566
    3 N1dacf7c78c5b4290897ea56019d92dda
    4 N265188fb7cee47138be0b7a33f6fedf4
    5 N2b0dc16f101e4cffbf4fa6b9a51161bf
    6 N3348437f3271417daf317d914a0f0b6b
    7 N386bc35e294c4d5f8baaa0a175a03340
    8 N3ae015160a7a4cd9b249287a8fd7c6aa
    9 N5ef5a0661bff42b686c6a4cc0c125563
    10 N80b4dd31f88748949a315987ced071d4
    11 N8859c47ebd324cc29f904de2d09b1fc8
    12 Naa87acf070144452a3cfe58f72f9c8f7
    13 Nbc00644896784e54bcdf5d280abe61ea
    14 Ndb72b4dd0d8c426d927a6e5ced1a8c71
    15 Ne57667213dba4b7e8b657c4ee3c483e0
    16 Nee8b01e416cf473e89e08bd7a5e6df34
    17 Nf0940b7e22574e179c72316f30e53a47
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author Nc66f82def02648c8b3bd8f01f1c141c7
    21 schema:citation sg:pub.10.1038/17130
    22 sg:pub.10.1038/339389a0
    23 sg:pub.10.1038/358495a0
    24 sg:pub.10.1038/381661a0
    25 sg:pub.10.1038/75556
    26 sg:pub.10.1038/nature00939
    27 sg:pub.10.1038/nature02343
    28 sg:pub.10.1038/nature06250
    29 sg:pub.10.1038/nature06553
    30 sg:pub.10.1038/nature08200
    31 sg:pub.10.1038/ng1202-569
    32 sg:pub.10.1038/nm.1871
    33 sg:pub.10.1038/nri2314
    34 sg:pub.10.1038/nri2377
    35 sg:pub.10.1186/1471-2148-7-214
    36 https://app.dimensions.ai/details/publication/pub.1074718098
    37 https://app.dimensions.ai/details/publication/pub.1082586007
    38 https://app.dimensions.ai/details/publication/pub.1082619619
    39 https://app.dimensions.ai/details/publication/pub.1082862586
    40 https://app.dimensions.ai/details/publication/pub.1083245096
    41 https://app.dimensions.ai/details/publication/pub.1083249090
    42 https://doi.org/10.1002/1521-4141(200112)31:12<3513::aid-immu3513>3.0.co;2-j
    43 https://doi.org/10.1002/jmv.21486
    44 https://doi.org/10.1006/viro.1996.0458
    45 https://doi.org/10.1016/0092-8674(89)90688-0
    46 https://doi.org/10.1016/0092-8674(93)90571-7
    47 https://doi.org/10.1016/j.cell.2006.04.033
    48 https://doi.org/10.1016/j.cell.2008.07.032
    49 https://doi.org/10.1016/j.chom.2008.10.004
    50 https://doi.org/10.1016/j.clim.2009.03.521
    51 https://doi.org/10.1016/j.it.2008.05.004
    52 https://doi.org/10.1016/j.virol.2004.08.024
    53 https://doi.org/10.1073/pnas.0307713101
    54 https://doi.org/10.1073/pnas.0409853102
    55 https://doi.org/10.1073/pnas.82.14.4813
    56 https://doi.org/10.1073/pnas.89.11.4835
    57 https://doi.org/10.1074/jbc.m109.006221
    58 https://doi.org/10.1089/aid.1992.8.27
    59 https://doi.org/10.1089/aid.2008.0113
    60 https://doi.org/10.1093/bioinformatics/btl140
    61 https://doi.org/10.1093/hmg/ddh183
    62 https://doi.org/10.1093/molbev/msi097
    63 https://doi.org/10.1093/molbev/msm088
    64 https://doi.org/10.1093/molbev/msp197
    65 https://doi.org/10.1093/nar/gkh340
    66 https://doi.org/10.1093/nar/gkm966
    67 https://doi.org/10.1093/nar/gkn708
    68 https://doi.org/10.1093/oxfordjournals.molbev.a025575
    69 https://doi.org/10.1093/oxfordjournals.molbev.a025629
    70 https://doi.org/10.1093/oxfordjournals.molbev.a026236
    71 https://doi.org/10.1097/00002030-199406000-00002
    72 https://doi.org/10.1097/00002030-199509040-00003
    73 https://doi.org/10.1101/gr.1239303
    74 https://doi.org/10.1101/gr.1933104
    75 https://doi.org/10.1111/j.1600-0684.2005.00122.x
    76 https://doi.org/10.1126/science.1123016
    77 https://doi.org/10.1126/science.1152725
    78 https://doi.org/10.1126/science.8235615
    79 https://doi.org/10.1128/jvi.00854-09
    80 https://doi.org/10.1128/jvi.74.7.3105-3111.2000
    81 https://doi.org/10.1128/jvi.76.13.6841-6844.2002
    82 https://doi.org/10.1128/jvi.77.22.12299-12309.2003
    83 https://doi.org/10.1128/jvi.77.7.4070-4080.2003
    84 https://doi.org/10.1139/o06-143
    85 https://doi.org/10.1146/annurev.immunol.17.1.657
    86 https://doi.org/10.1172/jci33034
    87 https://doi.org/10.1177/095632020501600601
    88 https://doi.org/10.1182/blood-2003-08-2928
    89 https://doi.org/10.1371/journal.pbio.0020275
    90 https://doi.org/10.1371/journal.pbio.0040072
    91 https://doi.org/10.1371/journal.pcbi.1000377
    92 https://doi.org/10.1371/journal.ppat.0040032
    93 https://doi.org/10.1371/journal.ppat.1000107
    94 https://doi.org/10.1371/journal.ppat.1000300
    95 https://doi.org/10.1371/journal.ppat.1000429
    96 https://doi.org/10.1371/journal.ppat.1000437
    97 schema:datePublished 2010-12
    98 schema:datePublishedReg 2010-12-01
    99 schema:description BACKGROUND: Positive selection of host proteins that interact with pathogens can indicate factors relevant for infection and potentially be a measure of pathogen driven evolution. RESULTS: Our analysis of 1439 primate genes and 175 lentivirus genomes points to specific host factors of high genetic variability that could account for differences in susceptibility to disease and indicate specific mechanisms of host defense and pathogen adaptation. We find that the largest amount of genetic change occurs in genes coding for cellular membrane proteins of the host as well as in the viral envelope genes suggesting cell entry and immune evasion as the primary evolutionary interface between host and pathogen. We additionally detect the innate immune response as a gene functional group harboring large differences among primates that could potentially account for the different levels of immune activation in the HIV/SIV primate infection. We find a significant correlation between the evolutionary rates of interacting host and viral proteins pointing to processes of the host-pathogen biology that are relatively conserved among species and to those undergoing accelerated genetic evolution. CONCLUSIONS: These results indicate specific host factors and their functional groups experiencing pathogen driven evolutionary selection pressures. Individual host factors pointed to by our analysis might merit further study as potential targets of antiretroviral therapies.
    100 schema:genre research_article
    101 schema:inLanguage en
    102 schema:isAccessibleForFree true
    103 schema:isPartOf Nb2f4a5bc412e474da7285e496acf5c06
    104 Nc7437a9e74e24d0ea9c1353a0bcbe26d
    105 sg:journal.1024249
    106 schema:name Positive selection of HIV host factors and the evolution of lentivirus genes
    107 schema:pagination 186
    108 schema:productId N12e226c2cffb4b1d851d9db2e9ff4a5a
    109 N2a016d52ec7a498eb1b86d5925dd357c
    110 N6d831f7058c641efa24cbd404ec0a443
    111 N8c60ab4fa1d543439cdd55247d5f255b
    112 Nf2a536bae8e44e24849e912ce7990901
    113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017181005
    114 https://doi.org/10.1186/1471-2148-10-186
    115 schema:sdDatePublished 2019-04-10T19:07
    116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    117 schema:sdPublisher Nc44eb8d28c4b48d89898ef27d4b5db7f
    118 schema:url http://link.springer.com/10.1186%2F1471-2148-10-186
    119 sgo:license sg:explorer/license/
    120 sgo:sdDataset articles
    121 rdf:type schema:ScholarlyArticle
    122 N0910a8a679904fad9c3a910459764f27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name RNA, Viral
    124 rdf:type schema:DefinedTerm
    125 N121691ccd05e4a7aadc5c7662d00a7b5 rdf:first sg:person.01360543616.07
    126 rdf:rest rdf:nil
    127 N12e226c2cffb4b1d851d9db2e9ff4a5a schema:name pubmed_id
    128 schema:value 20565842
    129 rdf:type schema:PropertyValue
    130 N1cdbec321e0d4ab888428f642e9f6566 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Selection, Genetic
    132 rdf:type schema:DefinedTerm
    133 N1dacf7c78c5b4290897ea56019d92dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Bayes Theorem
    135 rdf:type schema:DefinedTerm
    136 N265188fb7cee47138be0b7a33f6fedf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name HIV
    138 rdf:type schema:DefinedTerm
    139 N2a016d52ec7a498eb1b86d5925dd357c schema:name readcube_id
    140 schema:value 51db502d505317f079ee19e5d8522bf13ac4f8228ef9c5877d9d9c36f33a2230
    141 rdf:type schema:PropertyValue
    142 N2b0dc16f101e4cffbf4fa6b9a51161bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Sequence Analysis, DNA
    144 rdf:type schema:DefinedTerm
    145 N3348437f3271417daf317d914a0f0b6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Immunity, Innate
    147 rdf:type schema:DefinedTerm
    148 N386bc35e294c4d5f8baaa0a175a03340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Host-Pathogen Interactions
    150 rdf:type schema:DefinedTerm
    151 N3ae015160a7a4cd9b249287a8fd7c6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Primates
    153 rdf:type schema:DefinedTerm
    154 N5ef5a0661bff42b686c6a4cc0c125563 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Evolution, Molecular
    156 rdf:type schema:DefinedTerm
    157 N6d831f7058c641efa24cbd404ec0a443 schema:name doi
    158 schema:value 10.1186/1471-2148-10-186
    159 rdf:type schema:PropertyValue
    160 N80b4dd31f88748949a315987ced071d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Humans
    162 rdf:type schema:DefinedTerm
    163 N8859c47ebd324cc29f904de2d09b1fc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Phylogeny
    165 rdf:type schema:DefinedTerm
    166 N8c60ab4fa1d543439cdd55247d5f255b schema:name dimensions_id
    167 schema:value pub.1017181005
    168 rdf:type schema:PropertyValue
    169 Naa87acf070144452a3cfe58f72f9c8f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Animals
    171 rdf:type schema:DefinedTerm
    172 Nb2f4a5bc412e474da7285e496acf5c06 schema:volumeNumber 10
    173 rdf:type schema:PublicationVolume
    174 Nbc00644896784e54bcdf5d280abe61ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name HIV Infections
    176 rdf:type schema:DefinedTerm
    177 Nc44eb8d28c4b48d89898ef27d4b5db7f schema:name Springer Nature - SN SciGraph project
    178 rdf:type schema:Organization
    179 Nc66f82def02648c8b3bd8f01f1c141c7 rdf:first sg:person.01253301327.24
    180 rdf:rest N121691ccd05e4a7aadc5c7662d00a7b5
    181 Nc7437a9e74e24d0ea9c1353a0bcbe26d schema:issueNumber 1
    182 rdf:type schema:PublicationIssue
    183 Ndb72b4dd0d8c426d927a6e5ced1a8c71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name env Gene Products, Human Immunodeficiency Virus
    185 rdf:type schema:DefinedTerm
    186 Ne57667213dba4b7e8b657c4ee3c483e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Membrane Proteins
    188 rdf:type schema:DefinedTerm
    189 Nee8b01e416cf473e89e08bd7a5e6df34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Immune Evasion
    191 rdf:type schema:DefinedTerm
    192 Nf0940b7e22574e179c72316f30e53a47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Comparative Genomic Hybridization
    194 rdf:type schema:DefinedTerm
    195 Nf2a536bae8e44e24849e912ce7990901 schema:name nlm_unique_id
    196 schema:value 100966975
    197 rdf:type schema:PropertyValue
    198 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Biological Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Genetics
    203 rdf:type schema:DefinedTerm
    204 sg:journal.1024249 schema:issn 1471-2148
    205 schema:name BMC Evolutionary Biology
    206 rdf:type schema:Periodical
    207 sg:person.01253301327.24 schema:affiliation https://www.grid.ac/institutes/grid.419528.3
    208 schema:familyName Bożek
    209 schema:givenName Katarzyna
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253301327.24
    211 rdf:type schema:Person
    212 sg:person.01360543616.07 schema:affiliation https://www.grid.ac/institutes/grid.419528.3
    213 schema:familyName Lengauer
    214 schema:givenName Thomas
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360543616.07
    216 rdf:type schema:Person
    217 sg:pub.10.1038/17130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021010829
    218 https://doi.org/10.1038/17130
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/339389a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014105555
    221 https://doi.org/10.1038/339389a0
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/358495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043363104
    224 https://doi.org/10.1038/358495a0
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/381661a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053562821
    227 https://doi.org/10.1038/381661a0
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
    230 https://doi.org/10.1038/75556
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nature00939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012721182
    233 https://doi.org/10.1038/nature00939
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nature02343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031314486
    236 https://doi.org/10.1038/nature02343
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nature06250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036876479
    239 https://doi.org/10.1038/nature06250
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nature06553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050660540
    242 https://doi.org/10.1038/nature06553
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/nature08200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019644195
    245 https://doi.org/10.1038/nature08200
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ng1202-569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050075068
    248 https://doi.org/10.1038/ng1202-569
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nm.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019300068
    251 https://doi.org/10.1038/nm.1871
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nri2314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024668704
    254 https://doi.org/10.1038/nri2314
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nri2377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026942564
    257 https://doi.org/10.1038/nri2377
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/1471-2148-7-214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010584451
    260 https://doi.org/10.1186/1471-2148-7-214
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1074718098 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1082586007 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1082619619 schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1082862586 schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1083245096 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1083249090 schema:CreativeWork
    268 https://doi.org/10.1002/1521-4141(200112)31:12<3513::aid-immu3513>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1040351407
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/jmv.21486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047693885
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1006/viro.1996.0458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036405340
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/0092-8674(89)90688-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050830960
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/0092-8674(93)90571-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052667845
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.cell.2006.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004216542
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.cell.2008.07.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033459273
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.chom.2008.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003348718
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.clim.2009.03.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047698606
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.it.2008.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007701750
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.virol.2004.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008830963
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1073/pnas.0307713101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038227904
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1073/pnas.0409853102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030254365
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1073/pnas.82.14.4813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008456364
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1073/pnas.89.11.4835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039812025
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1074/jbc.m109.006221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042261931
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1089/aid.1992.8.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223481
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1089/aid.2008.0113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008173980
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/bioinformatics/btl140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033741877
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1093/hmg/ddh183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039101786
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1093/molbev/msi097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009754204
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/molbev/msm088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020427894
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1093/molbev/msp197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038735790
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1093/nar/gkh340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025846396
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/nar/gkm966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019249723
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/nar/gkn708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009228613
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/oxfordjournals.molbev.a025575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010735164
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/oxfordjournals.molbev.a025629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014813751
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/oxfordjournals.molbev.a026236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050352635
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1097/00002030-199406000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021275417
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1097/00002030-199509040-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050558220
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1101/gr.1933104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028112195
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1111/j.1600-0684.2005.00122.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021473929
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1126/science.1123016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453415
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1126/science.1152725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017813843
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1126/science.8235615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653749
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1128/jvi.00854-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035412361
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1128/jvi.74.7.3105-3111.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003046335
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1128/jvi.76.13.6841-6844.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047644569
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1128/jvi.77.22.12299-12309.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047700604
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1128/jvi.77.7.4070-4080.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023812525
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1139/o06-143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037009600
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1146/annurev.immunol.17.1.657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018153442
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1172/jci33034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003559067
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1177/095632020501600601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037232074
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1182/blood-2003-08-2928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000815920
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1371/journal.pbio.0020275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014347029
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1371/journal.pbio.0040072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030948598
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1371/journal.pcbi.1000377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033121588
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1371/journal.ppat.0040032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016470445
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1371/journal.ppat.1000107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021716150
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1371/journal.ppat.1000300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025276191
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1371/journal.ppat.1000429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039498707
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1371/journal.ppat.1000437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026806356
    377 rdf:type schema:CreativeWork
    378 https://www.grid.ac/institutes/grid.419528.3 schema:alternateName Max Planck Institute for Informatics
    379 schema:name Max Planck Institute for Informatics Computational Biology and Applied Algorithmics, Campus E1 4, 66123, Saarbrücken, Germany
    380 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...