Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Misa U Austin, Wei-Siang Liau, Krishnaswamy Balamurugan, Balasubramaniem Ashokkumar, Hamid M Said, Craig W LaMunyon

ABSTRACT

BACKGROUND: The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the source of the sterility and the effect of the folt-1 knockout on somatic function. RESULTS: Our results show that folt-1(ok1460) knockout hermaphrodites have a substantially reduced germline, generate a small number of functional sperm, and only rarely produce a functional oocyte. We found no evidence of increased apoptosis in the germline of folt-1 knockout mutants, suggesting that germline proliferation is defective. While folt-1 knockout males are fertile, their rate of spermatogenesis was severely diminished, and the males were very poor maters. The mating defect is likely due to compromised metabolism and/or other somatic functions, as folt-1 knockout hermaphrodites displayed a shortened lifespan and elongated defecation intervals. CONCLUSIONS: The FOLT-1 protein function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and here, nematodes. More... »

PAGES

46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-213x-10-46

DOI

http://dx.doi.org/10.1186/1471-213x-10-46

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047517356

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20441590


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disorders of Sex Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Folic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockout Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longevity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organic Anion Transporters", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Biological Sciences, California State University Pomona, 91768, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Austin", 
        "givenName": "Misa U", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biological Sciences, California State University Pomona, 91768, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liau", 
        "givenName": "Wei-Siang", 
        "id": "sg:person.0661465612.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661465612.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Irvine", 
          "id": "https://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "Veterans Affairs Medical Center, 90822, Long Beach, CA, USA", 
            "Departments of Medicine and Physiology/Biophysics, University of California, 92697, Irvine, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balamurugan", 
        "givenName": "Krishnaswamy", 
        "id": "sg:person.01200262572.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200262572.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Irvine", 
          "id": "https://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "Veterans Affairs Medical Center, 90822, Long Beach, CA, USA", 
            "Departments of Medicine and Physiology/Biophysics, University of California, 92697, Irvine, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ashokkumar", 
        "givenName": "Balasubramaniem", 
        "id": "sg:person.0702752744.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702752744.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Irvine", 
          "id": "https://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "Veterans Affairs Medical Center, 90822, Long Beach, CA, USA", 
            "Departments of Medicine and Physiology/Biophysics, University of California, 92697, Irvine, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Said", 
        "givenName": "Hamid M", 
        "id": "sg:person.01301745516.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301745516.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biological Sciences, California State University Pomona, 91768, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LaMunyon", 
        "givenName": "Craig W", 
        "id": "sg:person.0756132007.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756132007.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.25.2.751-766.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000295793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(80)90520-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.8429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003458510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360456a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004967643", 
          "https://doi.org/10.1038/360456a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.01-08-0422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005627588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.nu.16.070196.002441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008310730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.nutr.19.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009221045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530130055028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010630844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00516.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011050712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0177(200005)218:1<2::aid-dvdy2>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012093799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0027-5107(74)90098-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012777155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m005163200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014495914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199212243272602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015303403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2006.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017898255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspb.1998.0531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018116221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1997.8728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020030502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(03)00070-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020546918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(03)00070-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020546918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021194286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1065768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021498251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2007.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022921949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0050237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023090616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20031807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024952818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20031807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024952818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa031145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025085130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2005.00357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030272249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2005.00357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030272249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwg189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030390207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031981702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdrc.20100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032368148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.09.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034570301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.279.5.359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034834983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1993.03500100055027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036839745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038117793", 
          "https://doi.org/10.1038/sj.ejhg.5200946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038117793", 
          "https://doi.org/10.1038/sj.ejhg.5200946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000905200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041273778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0921-8734(90)90022-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042650958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2156-8-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043593485", 
          "https://doi.org/10.1186/1471-2156-8-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/cclm.2007.345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044031999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfj036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045653594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(03)00032-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045804669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(03)00032-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045804669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.10195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046193630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530210052030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047109640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m802812200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047133053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047140504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.2003.010694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049962274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/29331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050418051", 
          "https://doi.org/10.1038/29331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/29331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050418051", 
          "https://doi.org/10.1038/29331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.20.11399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052199137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11357-000-0007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052823995", 
          "https://doi.org/10.1007/s11357-000-0007-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.269.10.1257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054155165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.274.13.1049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054158801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.274.21.1698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054159044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2001-19739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057412205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1895/wormbook.1.127.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068724109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1895/wormbook.1.13.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068724112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1895/wormbook.1.53.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068724207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074543940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/130.2.129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074605260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074801705", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077356036", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080300025", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083099539", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083382740", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083383812", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the source of the sterility and the effect of the folt-1 knockout on somatic function.\nRESULTS: Our results show that folt-1(ok1460) knockout hermaphrodites have a substantially reduced germline, generate a small number of functional sperm, and only rarely produce a functional oocyte. We found no evidence of increased apoptosis in the germline of folt-1 knockout mutants, suggesting that germline proliferation is defective. While folt-1 knockout males are fertile, their rate of spermatogenesis was severely diminished, and the males were very poor maters. The mating defect is likely due to compromised metabolism and/or other somatic functions, as folt-1 knockout hermaphrodites displayed a shortened lifespan and elongated defecation intervals.\nCONCLUSIONS: The FOLT-1 protein function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and here, nematodes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-213x-10-46", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2609397", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2679998", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2670377", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024247", 
        "issn": [
          "1471-213X"
        ], 
        "name": "BMC Developmental Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans", 
    "pagination": "46", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e25b5de0460ad29f5dfb40793a4793be59c74d2f094366c63ef4c507ed6a5628"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20441590"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966973"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-213x-10-46"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047517356"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-213x-10-46", 
      "https://app.dimensions.ai/details/publication/pub.1047517356"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-213X-10-46"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-213x-10-46'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-213x-10-46'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-213x-10-46'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-213x-10-46'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      99 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-213x-10-46 schema:about N078a3c638d8a43258c7c94c785bc7fba
2 N11837ea470f442adac3784a2383a10a7
3 N26e516936ff146d0b0351534610969b8
4 N31390d6e0b0c40408fe9bded6604a663
5 N3eed558b07374b4cb7573275c03e8ba3
6 N5b60ca556a724be3b15e795b07bd4ad4
7 N5d9552ab71e74c67ac62a2f0517929aa
8 N91bffa66f97a41c6b6091487c0ae0481
9 Ne4bf23fb6e5c4497afc88cbc77fddd85
10 Nfe07193770ca4f28a355641c18d42fe5
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author Ndb5eb5aeb84b46b4a41f309c143301a4
14 schema:citation sg:pub.10.1007/s11357-000-0007-8
15 sg:pub.10.1038/29331
16 sg:pub.10.1038/360456a0
17 sg:pub.10.1038/sj.ejhg.5200946
18 sg:pub.10.1186/1471-2156-8-8
19 https://app.dimensions.ai/details/publication/pub.1074543940
20 https://app.dimensions.ai/details/publication/pub.1074801705
21 https://app.dimensions.ai/details/publication/pub.1077356036
22 https://app.dimensions.ai/details/publication/pub.1080300025
23 https://app.dimensions.ai/details/publication/pub.1083099539
24 https://app.dimensions.ai/details/publication/pub.1083382740
25 https://app.dimensions.ai/details/publication/pub.1083383812
26 https://doi.org/10.1001/jama.1993.03500100055027
27 https://doi.org/10.1001/jama.1995.03530130055028
28 https://doi.org/10.1001/jama.1995.03530210052030
29 https://doi.org/10.1001/jama.269.10.1257
30 https://doi.org/10.1001/jama.274.13.1049
31 https://doi.org/10.1001/jama.274.21.1698
32 https://doi.org/10.1001/jama.279.5.359
33 https://doi.org/10.1002/(sici)1097-0177(200005)218:1<2::aid-dvdy2>3.0.co;2-w
34 https://doi.org/10.1002/ajmg.10195
35 https://doi.org/10.1002/bdrc.20100
36 https://doi.org/10.1006/dbio.1996.8429
37 https://doi.org/10.1006/dbio.1997.8728
38 https://doi.org/10.1016/0027-5107(74)90098-0
39 https://doi.org/10.1016/0092-8674(80)90520-6
40 https://doi.org/10.1016/0921-8734(90)90022-j
41 https://doi.org/10.1016/j.cell.2006.09.041
42 https://doi.org/10.1016/j.jnutbio.2007.05.003
43 https://doi.org/10.1016/j.tig.2006.08.006
44 https://doi.org/10.1016/s0166-2236(03)00032-8
45 https://doi.org/10.1016/s0531-5565(03)00070-6
46 https://doi.org/10.1042/bj20031807
47 https://doi.org/10.1055/s-2001-19739
48 https://doi.org/10.1056/nejm199212243272602
49 https://doi.org/10.1056/nejmoa031145
50 https://doi.org/10.1073/pnas.96.20.11399
51 https://doi.org/10.1074/jbc.c000905200
52 https://doi.org/10.1074/jbc.m005163200
53 https://doi.org/10.1074/jbc.m802812200
54 https://doi.org/10.1091/mbc.01-08-0422
55 https://doi.org/10.1093/aje/kwg189
56 https://doi.org/10.1093/jn/130.2.129
57 https://doi.org/10.1093/nar/gkh982
58 https://doi.org/10.1093/toxsci/kfj036
59 https://doi.org/10.1098/rspb.1998.0531
60 https://doi.org/10.1111/j.1600-0897.2005.00357.x
61 https://doi.org/10.1126/science.1065768
62 https://doi.org/10.1128/mcb.25.2.751-766.2005
63 https://doi.org/10.1136/jmg.2003.010694
64 https://doi.org/10.1146/annurev.nu.16.070196.002441
65 https://doi.org/10.1146/annurev.nutr.19.1.91
66 https://doi.org/10.1152/ajpcell.00516.2006
67 https://doi.org/10.1242/dev.00914
68 https://doi.org/10.1371/journal.pbio.0050237
69 https://doi.org/10.1371/journal.pgen.1000213
70 https://doi.org/10.1515/cclm.2007.345
71 https://doi.org/10.1895/wormbook.1.127.2
72 https://doi.org/10.1895/wormbook.1.13.1
73 https://doi.org/10.1895/wormbook.1.53.1
74 schema:datePublished 2010-12
75 schema:datePublishedReg 2010-12-01
76 schema:description BACKGROUND: The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the source of the sterility and the effect of the folt-1 knockout on somatic function. RESULTS: Our results show that folt-1(ok1460) knockout hermaphrodites have a substantially reduced germline, generate a small number of functional sperm, and only rarely produce a functional oocyte. We found no evidence of increased apoptosis in the germline of folt-1 knockout mutants, suggesting that germline proliferation is defective. While folt-1 knockout males are fertile, their rate of spermatogenesis was severely diminished, and the males were very poor maters. The mating defect is likely due to compromised metabolism and/or other somatic functions, as folt-1 knockout hermaphrodites displayed a shortened lifespan and elongated defecation intervals. CONCLUSIONS: The FOLT-1 protein function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and here, nematodes.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N72f43b5043ff4948b01db1b3f67e73fe
81 Nd6584b46d1814e4bb413edf65298a75c
82 sg:journal.1024247
83 schema:name Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans
84 schema:pagination 46
85 schema:productId N19ee167ddc9c4d6e8730e084a6d8fede
86 N47e84266e553470ca803a19b4183c636
87 N53810062cd394f19a6adebf26c4ebaf8
88 N9669324799224140abea5c8f8fb1845b
89 Nba96ef9177ec4efaae5afa3aedfefe18
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047517356
91 https://doi.org/10.1186/1471-213x-10-46
92 schema:sdDatePublished 2019-04-10T16:49
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Ne30dddf3118343b5a429ab48a03cbc9c
95 schema:url http://link.springer.com/10.1186%2F1471-213X-10-46
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N078a3c638d8a43258c7c94c785bc7fba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Germ Cells
101 rdf:type schema:DefinedTerm
102 N11837ea470f442adac3784a2383a10a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Gene Knockout Techniques
104 rdf:type schema:DefinedTerm
105 N133dc0198c344504b71b0411b9e90841 schema:affiliation Nb19fa7701e1b41428f9f6559f12f4284
106 schema:familyName Austin
107 schema:givenName Misa U
108 rdf:type schema:Person
109 N19ee167ddc9c4d6e8730e084a6d8fede schema:name readcube_id
110 schema:value e25b5de0460ad29f5dfb40793a4793be59c74d2f094366c63ef4c507ed6a5628
111 rdf:type schema:PropertyValue
112 N26e516936ff146d0b0351534610969b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Disorders of Sex Development
114 rdf:type schema:DefinedTerm
115 N27e237d62e434e5a99a69253d0dbb294 rdf:first sg:person.01301745516.90
116 rdf:rest Nc501de5124d645289bc91dda554c4b3d
117 N28ca3fff66d54b208778204495e4b227 rdf:first sg:person.01200262572.09
118 rdf:rest N7b0655a1bef84ad585ff888facbb5071
119 N31390d6e0b0c40408fe9bded6604a663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 N3eed558b07374b4cb7573275c03e8ba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Longevity
124 rdf:type schema:DefinedTerm
125 N47e84266e553470ca803a19b4183c636 schema:name pubmed_id
126 schema:value 20441590
127 rdf:type schema:PropertyValue
128 N53810062cd394f19a6adebf26c4ebaf8 schema:name dimensions_id
129 schema:value pub.1047517356
130 rdf:type schema:PropertyValue
131 N5b60ca556a724be3b15e795b07bd4ad4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Caenorhabditis elegans
133 rdf:type schema:DefinedTerm
134 N5d9552ab71e74c67ac62a2f0517929aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Folic Acid
136 rdf:type schema:DefinedTerm
137 N72f43b5043ff4948b01db1b3f67e73fe schema:issueNumber 1
138 rdf:type schema:PublicationIssue
139 N74a082a5e382439bbdbcc64182f1fe4d rdf:first sg:person.0661465612.62
140 rdf:rest N28ca3fff66d54b208778204495e4b227
141 N7b0655a1bef84ad585ff888facbb5071 rdf:first sg:person.0702752744.82
142 rdf:rest N27e237d62e434e5a99a69253d0dbb294
143 N91bffa66f97a41c6b6091487c0ae0481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Organic Anion Transporters
145 rdf:type schema:DefinedTerm
146 N9669324799224140abea5c8f8fb1845b schema:name doi
147 schema:value 10.1186/1471-213x-10-46
148 rdf:type schema:PropertyValue
149 Na1177b047aa946b4b4bef1fda3e6d30c schema:name Department of Biological Sciences, California State University Pomona, 91768, CA, USA
150 rdf:type schema:Organization
151 Nb19fa7701e1b41428f9f6559f12f4284 schema:name Department of Biological Sciences, California State University Pomona, 91768, CA, USA
152 rdf:type schema:Organization
153 Nb30e4f9e101c4ce287fd3f0fc95fb79d schema:name Department of Biological Sciences, California State University Pomona, 91768, CA, USA
154 rdf:type schema:Organization
155 Nba96ef9177ec4efaae5afa3aedfefe18 schema:name nlm_unique_id
156 schema:value 100966973
157 rdf:type schema:PropertyValue
158 Nc501de5124d645289bc91dda554c4b3d rdf:first sg:person.0756132007.01
159 rdf:rest rdf:nil
160 Nd6584b46d1814e4bb413edf65298a75c schema:volumeNumber 10
161 rdf:type schema:PublicationVolume
162 Ndb5eb5aeb84b46b4a41f309c143301a4 rdf:first N133dc0198c344504b71b0411b9e90841
163 rdf:rest N74a082a5e382439bbdbcc64182f1fe4d
164 Ne30dddf3118343b5a429ab48a03cbc9c schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Ne4bf23fb6e5c4497afc88cbc77fddd85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 Nfe07193770ca4f28a355641c18d42fe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Caenorhabditis elegans Proteins
171 rdf:type schema:DefinedTerm
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
176 schema:name Genetics
177 rdf:type schema:DefinedTerm
178 sg:grant.2609397 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-213x-10-46
179 rdf:type schema:MonetaryGrant
180 sg:grant.2670377 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-213x-10-46
181 rdf:type schema:MonetaryGrant
182 sg:grant.2679998 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-213x-10-46
183 rdf:type schema:MonetaryGrant
184 sg:journal.1024247 schema:issn 1471-213X
185 schema:name BMC Developmental Biology
186 rdf:type schema:Periodical
187 sg:person.01200262572.09 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
188 schema:familyName Balamurugan
189 schema:givenName Krishnaswamy
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200262572.09
191 rdf:type schema:Person
192 sg:person.01301745516.90 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
193 schema:familyName Said
194 schema:givenName Hamid M
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301745516.90
196 rdf:type schema:Person
197 sg:person.0661465612.62 schema:affiliation Nb30e4f9e101c4ce287fd3f0fc95fb79d
198 schema:familyName Liau
199 schema:givenName Wei-Siang
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661465612.62
201 rdf:type schema:Person
202 sg:person.0702752744.82 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
203 schema:familyName Ashokkumar
204 schema:givenName Balasubramaniem
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702752744.82
206 rdf:type schema:Person
207 sg:person.0756132007.01 schema:affiliation Na1177b047aa946b4b4bef1fda3e6d30c
208 schema:familyName LaMunyon
209 schema:givenName Craig W
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756132007.01
211 rdf:type schema:Person
212 sg:pub.10.1007/s11357-000-0007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052823995
213 https://doi.org/10.1007/s11357-000-0007-8
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/29331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050418051
216 https://doi.org/10.1038/29331
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/360456a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004967643
219 https://doi.org/10.1038/360456a0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/sj.ejhg.5200946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038117793
222 https://doi.org/10.1038/sj.ejhg.5200946
223 rdf:type schema:CreativeWork
224 sg:pub.10.1186/1471-2156-8-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043593485
225 https://doi.org/10.1186/1471-2156-8-8
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1074543940 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1074801705 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1077356036 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1080300025 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1083099539 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1083382740 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1083383812 schema:CreativeWork
234 https://doi.org/10.1001/jama.1993.03500100055027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036839745
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1001/jama.1995.03530130055028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010630844
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1001/jama.1995.03530210052030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047109640
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1001/jama.269.10.1257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054155165
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1001/jama.274.13.1049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158801
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1001/jama.274.21.1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054159044
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1001/jama.279.5.359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034834983
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/(sici)1097-0177(200005)218:1<2::aid-dvdy2>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1012093799
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/ajmg.10195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046193630
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/bdrc.20100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032368148
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1006/dbio.1996.8429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003458510
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1006/dbio.1997.8728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020030502
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0027-5107(74)90098-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012777155
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/0092-8674(80)90520-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000991761
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0921-8734(90)90022-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1042650958
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.cell.2006.09.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034570301
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.jnutbio.2007.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022921949
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.tig.2006.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017898255
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0166-2236(03)00032-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045804669
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0531-5565(03)00070-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020546918
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1042/bj20031807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024952818
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1055/s-2001-19739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057412205
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1056/nejm199212243272602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015303403
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejmoa031145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025085130
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.96.20.11399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052199137
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.c000905200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041273778
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1074/jbc.m005163200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014495914
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1074/jbc.m802812200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047133053
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1091/mbc.01-08-0422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005627588
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/aje/kwg189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030390207
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/jn/130.2.129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074605260
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/nar/gkh982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047140504
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/toxsci/kfj036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045653594
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1098/rspb.1998.0531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018116221
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/j.1600-0897.2005.00357.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030272249
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1126/science.1065768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021498251
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1128/mcb.25.2.751-766.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000295793
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1136/jmg.2003.010694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049962274
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1146/annurev.nu.16.070196.002441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008310730
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1146/annurev.nutr.19.1.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009221045
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1152/ajpcell.00516.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011050712
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1242/dev.00914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021194286
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1371/journal.pbio.0050237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023090616
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pgen.1000213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031981702
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1515/cclm.2007.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044031999
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1895/wormbook.1.127.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068724109
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1895/wormbook.1.13.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068724112
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1895/wormbook.1.53.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068724207
329 rdf:type schema:CreativeWork
330 https://www.grid.ac/institutes/grid.266093.8 schema:alternateName University of California, Irvine
331 schema:name Departments of Medicine and Physiology/Biophysics, University of California, 92697, Irvine, CA, USA
332 Veterans Affairs Medical Center, 90822, Long Beach, CA, USA
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...