Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01-30

AUTHORS

William Raoul, Orianne Wagner-Ballon, Guitanouch Saber, Anne Hulin, Elisabeth Marcos, Stéphane Giraudier, William Vainchenker, Serge Adnot, Saadia Eddahibi, Bernard Maitre

ABSTRACT

BackgroundBone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown.ObjectivesWe investigated the effect of BMDCs on PH induced in mice by either monocrotaline or exposure to chronic hypoxia.MethodsIntravenous administration of the active monocrotaline metabolite (monocrotaline pyrrole, MCTp) to C57BL/6 mice induced PH within 15 days, due to remodeling of small distal vessels. Three days after the MCTp injection, the mice were injected with BMDCs harvested from femurs and tibias of donor mice treated with 5-fluorouracil (3.5 mg IP/animal) to deplete mature cells and to allow proliferation of progenitor cells.ResultsBMDCs significantly attenuated PH as assessed by reductions in right ventricular systolic pressure (20 ± 1 mmHg vs. 27 ± 1 mmHg, P ≤ 0.01), right ventricle weight/left ventricle+septum weight ratio (0.29 ± 0.02 vs. 0.36 ± 0.01, P ≤ 0.03), and percentage of muscularized vessels (26.4% vs. 33.5%, P ≤ 0.05), compared to control animals treated with irradiated BMDCs. Tracking cells from constitutive GFP-expressing male donor mice with anti-GFP antibodies or chromosome Y level measurement by quantitative real-time PCR showed BMDCs in the lung. In contrast, chronically hypoxic mice subjected to the same procedure failed to show improvement in PH.ConclusionThese results show that BMDCs limit pulmonary vascular remodeling induced by vascular injury but not by hypoxia. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1465-9921-8-8

DOI

http://dx.doi.org/10.1186/1465-9921-8-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042555084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17263874


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53 distal vessels
54 donor mice
55 effect
56 exposure
57 femur
58 hypertension
59 hypoxia
60 hypoxia-induced pulmonary hypertension
61 hypoxic mice
62 improvement
63 injection
64 injury
65 level measurements
66 lung
67 male donor mice
68 marrow-derived cells
69 mature cells
70 measurements
71 mechanism
72 metabolites
73 mice
74 monocrotaline
75 muscularized vessels
76 percentage
77 pressure
78 procedure
79 process
80 progenitor cells
81 proliferation
82 pulmonary hypertension
83 pulmonary vascular remodeling
84 quantitative real-time PCR
85 ratio
86 real-time PCR
87 reduction
88 remodeling
89 results
90 right ventricular systolic pressure
91 same procedure
92 small distal vessels
93 systolic pressure
94 tibia
95 tracking cells
96 vascular injury
97 vascular remodeling
98 ventricular systolic pressure
99 vessels
100 weight ratio
101 weight/
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