WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

Lynne Bingle, Simon S Cross, Alec S High, William A Wallace, Doris Rassl, Guanglu Yuan, Ingegerd Hellstrom, Michael A Campos, Colin D Bingle

ABSTRACT

BACKGROUND: The Whey Acidic Protein domain is an evolutionarily conserved motif found in a number of proteins, the best studied of which are antiproteinases involved in the innate immune defence of multiple epithelia. We recently characterised the WFDC2 gene which encodes a two WAP domain-containing protein, initially suggested as a marker for epididymis, and showed that it is highly expressed in the lung and salivary gland. The precise location of WFDC2 protein in these sites has not been described. METHODS: We used immunohistochemistry to localise WFDC2 in normal tissues of the respiratory tract, naso- and oropharynx, as well as in chronically inflamed lung from Cystic Fibrosis and a range of pulmonary carcinomas. We have complemented these studies with molecular analysis of WFDC2 gene expression in primary human lung cell cultures. RESULTS: WFDC2 is expressed in some epithelial cells of the upper airways as well as in mucous cells and ducts of submucosal glands. No staining was seen in peripheral lung. Intense staining is found in major salivary glands and in minor glands of the nose, sinuses, posterior tongue and tonsil. Studies with the related protein Secretory Leukocyte Protease Inhibitor (SLPI) show that although both proteins are expressed in similar tissues, the precise cellular localisation differs. Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis. SLPI expression was greatly reduced in the same samples. In cultures of tracheobronchial epithelial cells, expression of WFDC2 and SLPI are differentially regulated during differentiation yet WFDC2 is not induced by pro-inflammatory mediators. The majority of adenocarcinomas stain with WFDC2 whilst a significant minority of squamous, small cell and large cell carcinomas exhibit focal staining. There is no clear association with tumour grade. CONCLUSION: We believe that these studies support the hypothesis that WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. We also suggest that WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. More... »

PAGES

61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1465-9921-7-61

DOI

http://dx.doi.org/10.1186/1465-9921-7-61

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017711933

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16600032


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epididymal Secretory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Innate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory System", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bingle", 
        "givenName": "Lynne", 
        "id": "sg:person.01145737302.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737302.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cross", 
        "givenName": "Simon S", 
        "id": "sg:person.0661440166.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661440166.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Diagnostic Services Department, Level 6 Medical & Dental School, University of Leeds, Leeds, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "High", 
        "givenName": "Alec S", 
        "id": "sg:person.01021776463.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021776463.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Department of Pathology, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wallace", 
        "givenName": "William A", 
        "id": "sg:person.012660562232.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012660562232.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Papworth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417155.3", 
          "name": [
            "Department of Pathology, Papworth Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rassl", 
        "givenName": "Doris", 
        "id": "sg:person.01213210772.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213210772.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Guanglu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, University of Washington, Box 359939, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellstrom", 
        "givenName": "Ingegerd", 
        "id": "sg:person.01014567562.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014567562.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miami", 
          "id": "https://www.grid.ac/institutes/grid.26790.3a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, Florida, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campos", 
        "givenName": "Michael A", 
        "id": "sg:person.0757212234.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757212234.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bingle", 
        "givenName": "Colin D", 
        "id": "sg:person.0667373666.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667373666.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/mcp.m500041-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002742396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m500041-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002742396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003205525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003205525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4781(00)00196-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004979905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006199892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.154.4.8887613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006440308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)00670-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007459154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.04.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007839957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(99)00342-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008681714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010261806", 
          "https://doi.org/10.1038/sj.onc.1205363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010261806", 
          "https://doi.org/10.1038/sj.onc.1205363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.156.4.9701075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011681784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3400569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014614493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3400569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014614493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.241500798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2004-0250oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025493497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.99.13510299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026223718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod45.2.350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026484440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bc.2002.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027306013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2003-0142oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028391530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1093-3263(99)00023-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029513640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m909572199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030285072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/8.4.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031047452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034290222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/80489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035834447", 
          "https://doi.org/10.1038/80489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/80489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035834447", 
          "https://doi.org/10.1038/80489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e03-05-0279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037839330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81880-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038083034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(99)00035-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039207160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3160967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039594504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3160967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039594504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2002-0012oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041357973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02639383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044569289", 
          "https://doi.org/10.1007/bf02639383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348948209100308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044624095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348948209100308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044624095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/ajrcmb.25.1.4341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046541350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047109847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047553142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047553142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00065.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051613881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00065.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051613881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3400569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056713990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3430667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070321397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074510615", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074735181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075309854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082465678", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082988590", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083124346", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-12", 
    "datePublishedReg": "2006-12-01", 
    "description": "BACKGROUND: The Whey Acidic Protein domain is an evolutionarily conserved motif found in a number of proteins, the best studied of which are antiproteinases involved in the innate immune defence of multiple epithelia. We recently characterised the WFDC2 gene which encodes a two WAP domain-containing protein, initially suggested as a marker for epididymis, and showed that it is highly expressed in the lung and salivary gland. The precise location of WFDC2 protein in these sites has not been described.\nMETHODS: We used immunohistochemistry to localise WFDC2 in normal tissues of the respiratory tract, naso- and oropharynx, as well as in chronically inflamed lung from Cystic Fibrosis and a range of pulmonary carcinomas. We have complemented these studies with molecular analysis of WFDC2 gene expression in primary human lung cell cultures.\nRESULTS: WFDC2 is expressed in some epithelial cells of the upper airways as well as in mucous cells and ducts of submucosal glands. No staining was seen in peripheral lung. Intense staining is found in major salivary glands and in minor glands of the nose, sinuses, posterior tongue and tonsil. Studies with the related protein Secretory Leukocyte Protease Inhibitor (SLPI) show that although both proteins are expressed in similar tissues, the precise cellular localisation differs. Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis. SLPI expression was greatly reduced in the same samples. In cultures of tracheobronchial epithelial cells, expression of WFDC2 and SLPI are differentially regulated during differentiation yet WFDC2 is not induced by pro-inflammatory mediators. The majority of adenocarcinomas stain with WFDC2 whilst a significant minority of squamous, small cell and large cell carcinomas exhibit focal staining. There is no clear association with tumour grade.\nCONCLUSION: We believe that these studies support the hypothesis that WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. We also suggest that WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1465-9921-7-61", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028525", 
        "issn": [
          "1465-9921", 
          "1465-993X"
        ], 
        "name": "Respiratory Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung", 
    "pagination": "61", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5463fc74e2474dd759961e2955a9a95ee1a1bc70ef92e33d474ab7e53fb5f2b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16600032"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101090633"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1465-9921-7-61"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017711933"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1465-9921-7-61", 
      "https://app.dimensions.ai/details/publication/pub.1017711933"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/1465-9921-7-61"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-7-61'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-7-61'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-7-61'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-7-61'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      85 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1465-9921-7-61 schema:about N0181900937214bb5b729299cefabd1c0
2 N02237f4b7b8a4e63930de3825f1d6013
3 N078b2541a1e24b01939110c9d16c6ec2
4 N259c55cd192d4f05a4a42c3880b2cd9c
5 N4a82b66a38fa4edc9380730d75454e5a
6 N6429db1df0c24a7db96da35a7dc6f1e6
7 N7477fc3817574b169d4af660f2b44749
8 N8bb4acafdf81455dabda1e3a0597aba7
9 N94ba82ff826543bc9cecd9eeddf28865
10 Nb075bfa2d50f4016b85ecf88c71213a8
11 Nb6b104f1f9e3457ea743d15785f77920
12 Nc33b1337444c43b2b98bdab6ab692aaa
13 Neb3b1d0f5c74472991665369de8ba9d8
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author N4133d62bcf3d4b13ad2007711dc77d82
17 schema:citation sg:pub.10.1007/bf02639383
18 sg:pub.10.1038/80489
19 sg:pub.10.1038/sj.onc.1205363
20 https://app.dimensions.ai/details/publication/pub.1074510615
21 https://app.dimensions.ai/details/publication/pub.1074735181
22 https://app.dimensions.ai/details/publication/pub.1075309854
23 https://app.dimensions.ai/details/publication/pub.1082465678
24 https://app.dimensions.ai/details/publication/pub.1082988590
25 https://app.dimensions.ai/details/publication/pub.1083124346
26 https://doi.org/10.1002/path.1726
27 https://doi.org/10.1006/bbrc.1997.7720
28 https://doi.org/10.1016/j.ygyno.2005.06.040
29 https://doi.org/10.1016/s0014-5793(99)00670-5
30 https://doi.org/10.1016/s0092-8674(00)81880-2
31 https://doi.org/10.1016/s0167-4781(00)00196-2
32 https://doi.org/10.1016/s0378-1119(99)00035-9
33 https://doi.org/10.1016/s0378-1119(99)00342-x
34 https://doi.org/10.1016/s1093-3263(99)00023-6
35 https://doi.org/10.1042/0264-6021:3400569
36 https://doi.org/10.1042/bj3160967
37 https://doi.org/10.1042/bj3400569
38 https://doi.org/10.1042/bst0300098
39 https://doi.org/10.1042/bst0300116
40 https://doi.org/10.1073/pnas.241500798
41 https://doi.org/10.1074/jbc.m909572199
42 https://doi.org/10.1074/mcp.m500041-mcp200
43 https://doi.org/10.1091/mbc.e03-05-0279
44 https://doi.org/10.1093/molehr/8.4.341
45 https://doi.org/10.1095/biolreprod45.2.350
46 https://doi.org/10.1152/ajplung.00065.2005
47 https://doi.org/10.1158/0008-5472.can-04-3924
48 https://doi.org/10.1158/1078-0432.ccr-03-0409
49 https://doi.org/10.1164/ajrccm.154.4.8887613
50 https://doi.org/10.1164/ajrccm.156.4.9701075
51 https://doi.org/10.1165/ajrcmb.25.1.4341
52 https://doi.org/10.1165/rcmb.2002-0012oc
53 https://doi.org/10.1165/rcmb.2003-0142oc
54 https://doi.org/10.1165/rcmb.2004-0250oc
55 https://doi.org/10.1177/000348948209100308
56 https://doi.org/10.1183/09031936.99.13510299
57 https://doi.org/10.1200/jco.2004.04.109
58 https://doi.org/10.1515/bc.2002.138
59 https://doi.org/10.2307/3430667
60 schema:datePublished 2006-12
61 schema:datePublishedReg 2006-12-01
62 schema:description BACKGROUND: The Whey Acidic Protein domain is an evolutionarily conserved motif found in a number of proteins, the best studied of which are antiproteinases involved in the innate immune defence of multiple epithelia. We recently characterised the WFDC2 gene which encodes a two WAP domain-containing protein, initially suggested as a marker for epididymis, and showed that it is highly expressed in the lung and salivary gland. The precise location of WFDC2 protein in these sites has not been described. METHODS: We used immunohistochemistry to localise WFDC2 in normal tissues of the respiratory tract, naso- and oropharynx, as well as in chronically inflamed lung from Cystic Fibrosis and a range of pulmonary carcinomas. We have complemented these studies with molecular analysis of WFDC2 gene expression in primary human lung cell cultures. RESULTS: WFDC2 is expressed in some epithelial cells of the upper airways as well as in mucous cells and ducts of submucosal glands. No staining was seen in peripheral lung. Intense staining is found in major salivary glands and in minor glands of the nose, sinuses, posterior tongue and tonsil. Studies with the related protein Secretory Leukocyte Protease Inhibitor (SLPI) show that although both proteins are expressed in similar tissues, the precise cellular localisation differs. Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis. SLPI expression was greatly reduced in the same samples. In cultures of tracheobronchial epithelial cells, expression of WFDC2 and SLPI are differentially regulated during differentiation yet WFDC2 is not induced by pro-inflammatory mediators. The majority of adenocarcinomas stain with WFDC2 whilst a significant minority of squamous, small cell and large cell carcinomas exhibit focal staining. There is no clear association with tumour grade. CONCLUSION: We believe that these studies support the hypothesis that WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. We also suggest that WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N2682769fc51545eabf09a073efb8e34e
67 N623ea992240f4545bdcb9ae0ce9adf32
68 sg:journal.1028525
69 schema:name WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung
70 schema:pagination 61
71 schema:productId N2c06d97b853d43aeab52b8f9e090522f
72 N661e66573c0747339ed7a347c74f4b31
73 N715f9275903245988936f308090a587a
74 N8ff1bde483d94f129436e309653707b6
75 Na53610fa118f40dba3bd91de8dfa8801
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017711933
77 https://doi.org/10.1186/1465-9921-7-61
78 schema:sdDatePublished 2019-04-10T19:07
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N248d3114e386430186eb737f4dc8c743
81 schema:url http://link.springer.com/10.1186/1465-9921-7-61
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N0181900937214bb5b729299cefabd1c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Immunity, Innate
87 rdf:type schema:DefinedTerm
88 N02237f4b7b8a4e63930de3825f1d6013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Respiratory System
90 rdf:type schema:DefinedTerm
91 N078b2541a1e24b01939110c9d16c6ec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Lung Neoplasms
93 rdf:type schema:DefinedTerm
94 N219929c5c6ac410e9a04397621f5d741 rdf:first sg:person.01213210772.28
95 rdf:rest Nf6c2912ecafb4acdb31a6020dbda664d
96 N248d3114e386430186eb737f4dc8c743 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N259c55cd192d4f05a4a42c3880b2cd9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N2682769fc51545eabf09a073efb8e34e schema:volumeNumber 7
102 rdf:type schema:PublicationVolume
103 N2c06d97b853d43aeab52b8f9e090522f schema:name pubmed_id
104 schema:value 16600032
105 rdf:type schema:PropertyValue
106 N3841062b3de84945a07562e8a9a4b474 rdf:first sg:person.0661440166.43
107 rdf:rest Nf6f5afda603d48f38caa9758aa66fb1b
108 N4133d62bcf3d4b13ad2007711dc77d82 rdf:first sg:person.01145737302.37
109 rdf:rest N3841062b3de84945a07562e8a9a4b474
110 N4a82b66a38fa4edc9380730d75454e5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Adenocarcinoma
112 rdf:type schema:DefinedTerm
113 N56e33f7ae1fe465f877be0e3ccb56d03 schema:name Department of Pathology, University of Washington, Box 359939, Seattle, Washington, USA
114 rdf:type schema:Organization
115 N5b8095a1bf37443f907e88f011d3425d rdf:first sg:person.0757212234.16
116 rdf:rest Ned87f2c2595147e7a2e0fb00a86e86be
117 N623ea992240f4545bdcb9ae0ce9adf32 schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 N6429db1df0c24a7db96da35a7dc6f1e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cells, Cultured
121 rdf:type schema:DefinedTerm
122 N661e66573c0747339ed7a347c74f4b31 schema:name nlm_unique_id
123 schema:value 101090633
124 rdf:type schema:PropertyValue
125 N715f9275903245988936f308090a587a schema:name doi
126 schema:value 10.1186/1465-9921-7-61
127 rdf:type schema:PropertyValue
128 N7477fc3817574b169d4af660f2b44749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 N8bb4acafdf81455dabda1e3a0597aba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Line, Tumor
133 rdf:type schema:DefinedTerm
134 N8ff1bde483d94f129436e309653707b6 schema:name dimensions_id
135 schema:value pub.1017711933
136 rdf:type schema:PropertyValue
137 N94ba82ff826543bc9cecd9eeddf28865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mouth
139 rdf:type schema:DefinedTerm
140 Na53610fa118f40dba3bd91de8dfa8801 schema:name readcube_id
141 schema:value 5463fc74e2474dd759961e2955a9a95ee1a1bc70ef92e33d474ab7e53fb5f2b0
142 rdf:type schema:PropertyValue
143 Nb075bfa2d50f4016b85ecf88c71213a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Epididymal Secretory Proteins
145 rdf:type schema:DefinedTerm
146 Nb6b104f1f9e3457ea743d15785f77920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Biomarkers, Tumor
148 rdf:type schema:DefinedTerm
149 Nc33b1337444c43b2b98bdab6ab692aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 Nd94060fe6b834338a6a3635843efb8bb schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
153 schema:familyName Yuan
154 schema:givenName Guanglu
155 rdf:type schema:Person
156 Neb3b1d0f5c74472991665369de8ba9d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Proteins
158 rdf:type schema:DefinedTerm
159 Necc0f4f692724e29acb9af8d2599b377 rdf:first sg:person.01014567562.68
160 rdf:rest N5b8095a1bf37443f907e88f011d3425d
161 Ned87f2c2595147e7a2e0fb00a86e86be rdf:first sg:person.0667373666.74
162 rdf:rest rdf:nil
163 Nedec9f2c39a2468abe547d40ac1c98c5 rdf:first sg:person.012660562232.75
164 rdf:rest N219929c5c6ac410e9a04397621f5d741
165 Nf6c2912ecafb4acdb31a6020dbda664d rdf:first Nd94060fe6b834338a6a3635843efb8bb
166 rdf:rest Necc0f4f692724e29acb9af8d2599b377
167 Nf6f5afda603d48f38caa9758aa66fb1b rdf:first sg:person.01021776463.18
168 rdf:rest Nedec9f2c39a2468abe547d40ac1c98c5
169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
170 schema:name Biological Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biochemistry and Cell Biology
174 rdf:type schema:DefinedTerm
175 sg:journal.1028525 schema:issn 1465-9921
176 1465-993X
177 schema:name Respiratory Research
178 rdf:type schema:Periodical
179 sg:person.01014567562.68 schema:affiliation N56e33f7ae1fe465f877be0e3ccb56d03
180 schema:familyName Hellstrom
181 schema:givenName Ingegerd
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014567562.68
183 rdf:type schema:Person
184 sg:person.01021776463.18 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
185 schema:familyName High
186 schema:givenName Alec S
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021776463.18
188 rdf:type schema:Person
189 sg:person.01145737302.37 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
190 schema:familyName Bingle
191 schema:givenName Lynne
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145737302.37
193 rdf:type schema:Person
194 sg:person.01213210772.28 schema:affiliation https://www.grid.ac/institutes/grid.417155.3
195 schema:familyName Rassl
196 schema:givenName Doris
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213210772.28
198 rdf:type schema:Person
199 sg:person.012660562232.75 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
200 schema:familyName Wallace
201 schema:givenName William A
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012660562232.75
203 rdf:type schema:Person
204 sg:person.0661440166.43 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
205 schema:familyName Cross
206 schema:givenName Simon S
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661440166.43
208 rdf:type schema:Person
209 sg:person.0667373666.74 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
210 schema:familyName Bingle
211 schema:givenName Colin D
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667373666.74
213 rdf:type schema:Person
214 sg:person.0757212234.16 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
215 schema:familyName Campos
216 schema:givenName Michael A
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757212234.16
218 rdf:type schema:Person
219 sg:pub.10.1007/bf02639383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044569289
220 https://doi.org/10.1007/bf02639383
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/80489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035834447
223 https://doi.org/10.1038/80489
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.onc.1205363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010261806
226 https://doi.org/10.1038/sj.onc.1205363
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1074510615 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1074735181 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1075309854 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1082465678 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1082988590 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1083124346 schema:CreativeWork
234 https://doi.org/10.1002/path.1726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034290222
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1006/bbrc.1997.7720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043129186
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.ygyno.2005.06.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047553142
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0014-5793(99)00670-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007459154
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0092-8674(00)81880-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038083034
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0167-4781(00)00196-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004979905
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0378-1119(99)00035-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039207160
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0378-1119(99)00342-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008681714
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s1093-3263(99)00023-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029513640
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1042/0264-6021:3400569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056713990
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1042/bj3160967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039594504
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1042/bj3400569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014614493
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1042/bst0300098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003205525
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1042/bst0300116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006708528
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1073/pnas.241500798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053203
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1074/jbc.m909572199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030285072
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1074/mcp.m500041-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002742396
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1091/mbc.e03-05-0279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037839330
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/molehr/8.4.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031047452
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1095/biolreprod45.2.350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026484440
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1152/ajplung.00065.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051613881
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1158/0008-5472.can-04-3924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006199892
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1158/1078-0432.ccr-03-0409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047109847
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1164/ajrccm.154.4.8887613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006440308
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1164/ajrccm.156.4.9701075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681784
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1165/ajrcmb.25.1.4341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046541350
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1165/rcmb.2002-0012oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1041357973
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1165/rcmb.2003-0142oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1028391530
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1165/rcmb.2004-0250oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1025493497
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1177/000348948209100308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044624095
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1183/09031936.99.13510299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026223718
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1200/jco.2004.04.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007839957
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1515/bc.2002.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027306013
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2307/3430667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070321397
301 rdf:type schema:CreativeWork
302 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
303 schema:name Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK
304 Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK
305 Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.26790.3a schema:alternateName University of Miami
308 schema:name Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, Florida, USA
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.417155.3 schema:alternateName Papworth Hospital
311 schema:name Department of Pathology, Papworth Hospital, Cambridge, UK
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
314 schema:name Department of Pathology, University of Edinburgh, Edinburgh, UK
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.9909.9 schema:alternateName University of Leeds
317 schema:name Diagnostic Services Department, Level 6 Medical & Dental School, University of Leeds, Leeds, UK
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...