Epidemiology, radiology, and genetics of nicotine dependence in COPD View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12-01

AUTHORS

Deog Kyeom Kim, Craig P Hersh, George R Washko, John E Hokanson, David A Lynch, John D Newell, James R Murphy, James D Crapo, Edwin K Silverman, the COPD Gene Investigators

ABSTRACT

BackgroundCigarette smoking is the principal environmental risk factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers.MethodsCurrent smokers with COPD (GOLD stage ≥ 2) or normal spirometry were analyzed from the COPDGene Study, a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND). Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung <-950 HU) and gas trapping on expiratory CT (% of lung <-856 HU) were obtained. Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes.ResultsAmong 842 currently smoking subjects (335 COPD cases and 507 controls), 329 subjects (39.1%) showed high nicotine dependence. Subjects with high nicotine dependence had greater cumulative and current amounts of smoking. However, emphysema severity was negatively correlated with the FTND score in controls (ρ = -0.19, p < .0001) as well as in COPD cases (ρ = -0.18, p = 0.0008). Lower FTND score, male gender, lower body mass index, and lower FEV1 were independent risk factors for emphysema severity in COPD cases. Both CHRNA3/5 SNPs were associated with FTND in current smokers. An association of genetic variants in CHRNA3/5 with severity of emphysema was only found in former smokers, but not in current smokers.ConclusionsNicotine dependence was a negative predictor for emphysema on CT in COPD and control smokers. Increased inflammation in more highly addicted current smokers could influence the CT lung density distribution, which may influence genetic association studies of emphysema phenotypes.Trial registrationClinicalTrials (NCT): NCT00608764 More... »

PAGES

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1465-9921-12-9

DOI

http://dx.doi.org/10.1186/1465-9921-12-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038284933

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21232152


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41 schema:description BackgroundCigarette smoking is the principal environmental risk factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers.MethodsCurrent smokers with COPD (GOLD stage ≥ 2) or normal spirometry were analyzed from the COPDGene Study, a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND). Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung <-950 HU) and gas trapping on expiratory CT (% of lung <-856 HU) were obtained. Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes.ResultsAmong 842 currently smoking subjects (335 COPD cases and 507 controls), 329 subjects (39.1%) showed high nicotine dependence. Subjects with high nicotine dependence had greater cumulative and current amounts of smoking. However, emphysema severity was negatively correlated with the FTND score in controls (ρ = -0.19, p < .0001) as well as in COPD cases (ρ = -0.18, p = 0.0008). Lower FTND score, male gender, lower body mass index, and lower FEV1 were independent risk factors for emphysema severity in COPD cases. Both CHRNA3/5 SNPs were associated with FTND in current smokers. An association of genetic variants in CHRNA3/5 with severity of emphysema was only found in former smokers, but not in current smokers.ConclusionsNicotine dependence was a negative predictor for emphysema on CT in COPD and control smokers. Increased inflammation in more highly addicted current smokers could influence the CT lung density distribution, which may influence genetic association studies of emphysema phenotypes.Trial registrationClinicalTrials (NCT): NCT00608764
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48 CHRNA3/5
49 COPD
50 COPD cases
51 COPDGene study
52 CT
53 CT acquisition
54 CT findings
55 FEV1
56 FTND
57 FTND score
58 Fagerstrom Test
59 SNPs
60 acquisition
61 amount
62 association
63 association studies
64 behavior
65 body mass index
66 cases
67 control
68 control smokers
69 current amount
70 current smokers
71 density distribution
72 dependence
73 dependence phenotypes
74 distribution
75 emphysema
76 emphysema phenotype
77 emphysema severity
78 environmental risk factors
79 epidemiology
80 expiratory CT
81 factors
82 findings
83 former smokers
84 gas trapping
85 gender
86 genetic association studies
87 genetic susceptibility
88 genetic variants
89 genetics
90 genotypes
91 high nicotine dependence
92 independent risk factor
93 index
94 inflammation
95 inspiratory CT
96 lower FEV1
97 lower FTND scores
98 lower body mass index
99 male gender
100 mass index
101 negative predictor
102 nicotine dependence
103 nicotine dependence phenotypes
104 normal spirometry
105 observational study
106 percent
107 phenotype
108 predictors
109 principal environmental risk factor
110 prospective observational study
111 radiology
112 region
113 relationship
114 risk factors
115 scores
116 severity
117 severity of emphysema
118 smokers
119 smoking
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121 spirometry
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