Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Fang Zhou, Shigemitsu Onizawa, Atsushi Nagai, Kazutetsu Aoshiba

ABSTRACT

BACKGROUND: Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette smoke, induces premature cell senescence. Recent evidence indicates that cellular senescence of various types of cells is accelerated in COPD patients. However, whether the senescence of airway epithelial cells contributes to the development of airway diseases is unknown. The present study was designed to test the hypothesis that premature senescence of airway epithelial cells (Clara cells) impairs repair processes and exacerbates inflammation after airway injury. METHODS: C57/BL6J mice were injected with the Clara-cell-specific toxicant naphthalene (NA) on days 0, 7, and 14, and each NA injection was followed by a daily dose of BrdU on each of the following 3 days, during which regenerating cells were allowed to incorporate BrdU into their DNA and to senesce. The p38 MAPK inhibitor SB202190 was injected 30 minutes before each BrdU dose. Mice were sacrificed at different times until day 28 and lungs of mice were obtained to investigate whether Clara cell senescence impairs airway epithelial regeneration and exacerbates airway inflammation. NCI-H441 cells were induced to senesce by exposure to BrdU or the telomerase inhibitor MST-312. Human lung tissue samples were obtained from COPD patients, asymptomatic smokers, and nonsmokers to investigate whether Clara cell senescence is accelerated in the airways of COPD patients, and if so, whether it is accompanied by p38 MAPK activation. RESULTS: BrdU did not alter the intensity of the airway epithelial injury or inflammation after a single NA exposure. However, after repeated NA exposure, BrdU induced epithelial cell (Clara cell) senescence, as demonstrated by a DNA damage response, p21 overexpression, increased senescence-associated β-galactosidase activity, and growth arrest, which resulted in impaired epithelial regeneration. The epithelial senescence was accompanied by p38 MAPK-dependent airway inflammation. Senescent NCI-H441 cells impaired epithelial wound repair and secreted increased amounts of pro-inflammatory cytokines in a p38 MAPK-dependent manner. Clara cell senescence in COPD patients was accelerated and accompanied by p38 MAPK activation. CONCLUSIONS: Senescence of airway epithelial cells impairs repair processes and exacerbates p38 MAPK-dependent inflammation after airway injury, and it may contribute to the pathogenesis of COPD. More... »

PAGES

78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1465-9921-12-78

DOI

http://dx.doi.org/10.1186/1465-9921-12-78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031468272

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21663649


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Senescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthalenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smoking", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomerase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wound Healing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta-Galactosidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "p38 Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Pulmonary Division, Graduate School of Medical Science, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Fang", 
        "id": "sg:person.0675132611.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675132611.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "First Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onizawa", 
        "givenName": "Shigemitsu", 
        "id": "sg:person.01170672336.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170672336.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "First Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Atsushi", 
        "id": "sg:person.01167315617.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167315617.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Pulmonary Division, Graduate School of Medical Science, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan", 
            "First Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoshiba", 
        "givenName": "Kazutetsu", 
        "id": "sg:person.01352423511.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352423511.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000268287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000440407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00024.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003212310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003315718", 
          "https://doi.org/10.1038/leu.2010.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003315718", 
          "https://doi.org/10.1038/leu.2010.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2008-0299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004239319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-1110(91)90007-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007409248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-1110(91)90007-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007409248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008470674", 
          "https://doi.org/10.1038/ncb1909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2009.00481.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010470243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2009.00481.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010470243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011710145", 
          "https://doi.org/10.1038/nature05529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011710145", 
          "https://doi.org/10.1038/nature05529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2008-0353oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011863730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215549904700612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014542315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215549904700612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014542315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.57.070188.002025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014574790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.200904-017rm", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014591325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.06.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015334998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-7002-2_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017081238", 
          "https://doi.org/10.1007/978-1-4419-7002-2_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-7002-2_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017081238", 
          "https://doi.org/10.1007/978-1-4419-7002-2_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017164844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-5521(97)90194-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018287057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200809-1398oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019542810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9220-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021410177", 
          "https://doi.org/10.1007/s10555-010-9220-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9220-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021410177", 
          "https://doi.org/10.1007/s10555-010-9220-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2010/390791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021549849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.200907-078rm", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023158009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.03.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026622054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2003-0290oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026800122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026912786", 
          "https://doi.org/10.1038/onc.2009.318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4933-5-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027612736", 
          "https://doi.org/10.1186/1742-4933-5-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4933-5-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027612736", 
          "https://doi.org/10.1186/1742-4933-5-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)01595-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027739512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.10.4683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027772207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2008.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028401622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80420-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029074185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200509-1374oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029524812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.08-1419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029794002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.03.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029924676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030184692", 
          "https://doi.org/10.1038/nrc2560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030616797", 
          "https://doi.org/10.1038/nrm2233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2010.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033625660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00036707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033834799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.01150.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034777220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-7-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041806353", 
          "https://doi.org/10.1186/1465-9921-7-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2004.10.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046273413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.06.00087005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047686569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049061900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4933-3-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049271636", 
          "https://doi.org/10.1186/1742-4933-3-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.05.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051432284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.107.127092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052864400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0030-1254066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057219415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a022549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059961350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075203260", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.10.6504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077412744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081858248", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082801809", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1995.269.6.l791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082864420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1995.269.6.l800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082864421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1997.272.1.l28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083048441"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "BACKGROUND: Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette smoke, induces premature cell senescence. Recent evidence indicates that cellular senescence of various types of cells is accelerated in COPD patients. However, whether the senescence of airway epithelial cells contributes to the development of airway diseases is unknown. The present study was designed to test the hypothesis that premature senescence of airway epithelial cells (Clara cells) impairs repair processes and exacerbates inflammation after airway injury.\nMETHODS: C57/BL6J mice were injected with the Clara-cell-specific toxicant naphthalene (NA) on days 0, 7, and 14, and each NA injection was followed by a daily dose of BrdU on each of the following 3 days, during which regenerating cells were allowed to incorporate BrdU into their DNA and to senesce. The p38 MAPK inhibitor SB202190 was injected 30 minutes before each BrdU dose. Mice were sacrificed at different times until day 28 and lungs of mice were obtained to investigate whether Clara cell senescence impairs airway epithelial regeneration and exacerbates airway inflammation. NCI-H441 cells were induced to senesce by exposure to BrdU or the telomerase inhibitor MST-312. Human lung tissue samples were obtained from COPD patients, asymptomatic smokers, and nonsmokers to investigate whether Clara cell senescence is accelerated in the airways of COPD patients, and if so, whether it is accompanied by p38 MAPK activation.\nRESULTS: BrdU did not alter the intensity of the airway epithelial injury or inflammation after a single NA exposure. However, after repeated NA exposure, BrdU induced epithelial cell (Clara cell) senescence, as demonstrated by a DNA damage response, p21 overexpression, increased senescence-associated \u03b2-galactosidase activity, and growth arrest, which resulted in impaired epithelial regeneration. The epithelial senescence was accompanied by p38 MAPK-dependent airway inflammation. Senescent NCI-H441 cells impaired epithelial wound repair and secreted increased amounts of pro-inflammatory cytokines in a p38 MAPK-dependent manner. Clara cell senescence in COPD patients was accelerated and accompanied by p38 MAPK activation.\nCONCLUSIONS: Senescence of airway epithelial cells impairs repair processes and exacerbates p38 MAPK-dependent inflammation after airway injury, and it may contribute to the pathogenesis of COPD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1465-9921-12-78", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028525", 
        "issn": [
          "1465-9921", 
          "1465-993X"
        ], 
        "name": "Respiratory Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury", 
    "pagination": "78", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95e862f3c708814369785b409636e341848033a38726b7b9013cac89b953f371"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21663649"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101090633"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1465-9921-12-78"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031468272"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1465-9921-12-78", 
      "https://app.dimensions.ai/details/publication/pub.1031468272"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/1465-9921-12-78"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-12-78'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-12-78'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-12-78'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1465-9921-12-78'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      113 URIs      53 LITERALS      41 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1465-9921-12-78 schema:about N01d074555abd45b79d222d028ee31c77
2 N059ce4f8800546cb98379f4d6bba1407
3 N0832a2ba29da4930ac2160c03d056a1b
4 N0f2d6e72d5ce42ef9e077392da5c31e2
5 N117782789c2d4ef785c23b67bd2fbc3f
6 N1afde5118a8e4b8b833f655fb63eeb9d
7 N1c11cb6fdc1846b8b307f6e2dc68f3b8
8 N208fcfdd1a634cbb810a3485a5f179ce
9 N24c526155931457e90aa1aaaac9b57b2
10 N29fc26b29997493fa7f1f9e1929cb5bc
11 N2b89dc62a2e140518b8d48b7246164c5
12 N30491609b6544e50a3024daa20e889dd
13 N4459c68d1ca1416ba541c862b9cb5622
14 N56ace0d253db44eabfd78a1f5c3f6d6e
15 N5ad74739d6d34bae89921f7047a52aa7
16 N5f4a1e648931478094c2e653cd9706af
17 N644223d8f296455da358b5ee3757c7f0
18 N6ac986e688d349d5b0e58dc9f1a9cc31
19 N7093d6cefd9345d698aca76121d1ee20
20 N7dad61e4694344d5a768f1f168142f98
21 N84a047f6bdec4f18a6d95e7f34ff77fd
22 N88198fb6e2bf4b33831d29dc645367ea
23 N8da62ac534084e0fb9bed412793a10e2
24 N93d3f56c77ac45c3987413a9ac80da53
25 Nbd8299e444004ad58fa3a4376768e881
26 Nda2d08625e424929a5a477c5d20e6967
27 Ndadbaaa079ec45909a5d055bfe232d4c
28 Ndd0c87133ef04df1bb303f78de8eca21
29 Ne3e00b8c56d14b2798aa02ba70b57a07
30 Ne47a01ef85354e0aa48832640d40671b
31 Ne6d5572d25014b5c95627136ca65d48e
32 Nf4541b21821044d99e0147bbff0b0677
33 anzsrc-for:11
34 anzsrc-for:1102
35 schema:author Nb2a6fd2c43d246d18f9a7e6a388ec689
36 schema:citation sg:pub.10.1007/978-1-4419-7002-2_10
37 sg:pub.10.1007/s10555-010-9220-9
38 sg:pub.10.1038/leu.2010.6
39 sg:pub.10.1038/nature05529
40 sg:pub.10.1038/ncb1909
41 sg:pub.10.1038/nrc2560
42 sg:pub.10.1038/nrm2233
43 sg:pub.10.1038/onc.2009.318
44 sg:pub.10.1186/1465-9921-7-32
45 sg:pub.10.1186/1742-4933-3-4
46 sg:pub.10.1186/1742-4933-5-5
47 https://app.dimensions.ai/details/publication/pub.1075203260
48 https://app.dimensions.ai/details/publication/pub.1081858248
49 https://app.dimensions.ai/details/publication/pub.1082801809
50 https://doi.org/10.1016/0165-1110(91)90007-i
51 https://doi.org/10.1016/j.cell.2005.02.003
52 https://doi.org/10.1016/j.cell.2008.03.038
53 https://doi.org/10.1016/j.cell.2008.03.039
54 https://doi.org/10.1016/j.cell.2008.05.027
55 https://doi.org/10.1016/j.cell.2008.06.049
56 https://doi.org/10.1016/j.ijrobp.2009.10.009
57 https://doi.org/10.1016/j.molmed.2010.03.003
58 https://doi.org/10.1016/j.rmed.2008.04.013
59 https://doi.org/10.1016/j.yexcr.2004.10.036
60 https://doi.org/10.1016/s0960-9822(99)80420-5
61 https://doi.org/10.1016/s0968-0004(00)01595-4
62 https://doi.org/10.1016/s1074-5521(97)90194-0
63 https://doi.org/10.1055/s-0030-1254066
64 https://doi.org/10.1073/pnas.89.10.4683
65 https://doi.org/10.1093/oxfordjournals.jbchem.a022549
66 https://doi.org/10.1111/j.1474-9726.2009.00481.x
67 https://doi.org/10.1124/jpet.107.127092
68 https://doi.org/10.1146/annurev.bi.57.070188.002025
69 https://doi.org/10.1152/ajplung.00024.2007
70 https://doi.org/10.1152/ajplung.1995.269.6.l791
71 https://doi.org/10.1152/ajplung.1995.269.6.l800
72 https://doi.org/10.1152/ajplung.1997.272.1.l28
73 https://doi.org/10.1152/japplphysiol.01150.2004
74 https://doi.org/10.1159/000268287
75 https://doi.org/10.1164/rccm.200509-1374oc
76 https://doi.org/10.1164/rccm.200809-1398oc
77 https://doi.org/10.1165/rcmb.2003-0290oc
78 https://doi.org/10.1165/rcmb.2008-0353oc
79 https://doi.org/10.1177/002215549904700612
80 https://doi.org/10.1183/09031936.00036707
81 https://doi.org/10.1183/09031936.06.00087005
82 https://doi.org/10.1378/chest.08-1419
83 https://doi.org/10.1513/pats.200904-017rm
84 https://doi.org/10.1513/pats.200907-078rm
85 https://doi.org/10.1634/stemcells.2008-0299
86 https://doi.org/10.4049/jimmunol.178.10.6504
87 https://doi.org/10.4061/2010/390791
88 schema:datePublished 2011-12
89 schema:datePublishedReg 2011-12-01
90 schema:description BACKGROUND: Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette smoke, induces premature cell senescence. Recent evidence indicates that cellular senescence of various types of cells is accelerated in COPD patients. However, whether the senescence of airway epithelial cells contributes to the development of airway diseases is unknown. The present study was designed to test the hypothesis that premature senescence of airway epithelial cells (Clara cells) impairs repair processes and exacerbates inflammation after airway injury. METHODS: C57/BL6J mice were injected with the Clara-cell-specific toxicant naphthalene (NA) on days 0, 7, and 14, and each NA injection was followed by a daily dose of BrdU on each of the following 3 days, during which regenerating cells were allowed to incorporate BrdU into their DNA and to senesce. The p38 MAPK inhibitor SB202190 was injected 30 minutes before each BrdU dose. Mice were sacrificed at different times until day 28 and lungs of mice were obtained to investigate whether Clara cell senescence impairs airway epithelial regeneration and exacerbates airway inflammation. NCI-H441 cells were induced to senesce by exposure to BrdU or the telomerase inhibitor MST-312. Human lung tissue samples were obtained from COPD patients, asymptomatic smokers, and nonsmokers to investigate whether Clara cell senescence is accelerated in the airways of COPD patients, and if so, whether it is accompanied by p38 MAPK activation. RESULTS: BrdU did not alter the intensity of the airway epithelial injury or inflammation after a single NA exposure. However, after repeated NA exposure, BrdU induced epithelial cell (Clara cell) senescence, as demonstrated by a DNA damage response, p21 overexpression, increased senescence-associated β-galactosidase activity, and growth arrest, which resulted in impaired epithelial regeneration. The epithelial senescence was accompanied by p38 MAPK-dependent airway inflammation. Senescent NCI-H441 cells impaired epithelial wound repair and secreted increased amounts of pro-inflammatory cytokines in a p38 MAPK-dependent manner. Clara cell senescence in COPD patients was accelerated and accompanied by p38 MAPK activation. CONCLUSIONS: Senescence of airway epithelial cells impairs repair processes and exacerbates p38 MAPK-dependent inflammation after airway injury, and it may contribute to the pathogenesis of COPD.
91 schema:genre research_article
92 schema:inLanguage en
93 schema:isAccessibleForFree true
94 schema:isPartOf N2dbc089949d942049dad14eee6f12260
95 N66292c78fa874c2fa60e2501399bb7f2
96 sg:journal.1028525
97 schema:name Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
98 schema:pagination 78
99 schema:productId N31c87cbcb4f14ce1bcf4d5a008173d46
100 N7114e234f38c413398435f863e5b163d
101 Nd4e35b74b06a4429a7943de0cb269660
102 Nd52e8b8a52e74b6b95518f0fadff5d34
103 Ndf0cc23bc2f346d599af4b53cbd32862
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031468272
105 https://doi.org/10.1186/1465-9921-12-78
106 schema:sdDatePublished 2019-04-10T22:39
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher Nc894b32eb3e541b0840bb2fd990e5014
109 schema:url http://link.springer.com/10.1186/1465-9921-12-78
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N01d074555abd45b79d222d028ee31c77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Wound Healing
115 rdf:type schema:DefinedTerm
116 N059ce4f8800546cb98379f4d6bba1407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Pulmonary Disease, Chronic Obstructive
118 rdf:type schema:DefinedTerm
119 N0832a2ba29da4930ac2160c03d056a1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 N094531d6451b45a186a0ce6fc8526e7c rdf:first sg:person.01352423511.39
123 rdf:rest rdf:nil
124 N0f2d6e72d5ce42ef9e077392da5c31e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Middle Aged
126 rdf:type schema:DefinedTerm
127 N117782789c2d4ef785c23b67bd2fbc3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cyclin-Dependent Kinase Inhibitor p21
129 rdf:type schema:DefinedTerm
130 N1afde5118a8e4b8b833f655fb63eeb9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Inflammation Mediators
132 rdf:type schema:DefinedTerm
133 N1c11cb6fdc1846b8b307f6e2dc68f3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice, Inbred C57BL
135 rdf:type schema:DefinedTerm
136 N208fcfdd1a634cbb810a3485a5f179ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Telomerase
138 rdf:type schema:DefinedTerm
139 N24c526155931457e90aa1aaaac9b57b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Lung Injury
141 rdf:type schema:DefinedTerm
142 N29fc26b29997493fa7f1f9e1929cb5bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Time Factors
144 rdf:type schema:DefinedTerm
145 N2b89dc62a2e140518b8d48b7246164c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name beta-Galactosidase
147 rdf:type schema:DefinedTerm
148 N2dbc089949d942049dad14eee6f12260 schema:issueNumber 1
149 rdf:type schema:PublicationIssue
150 N30491609b6544e50a3024daa20e889dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mice
152 rdf:type schema:DefinedTerm
153 N31c87cbcb4f14ce1bcf4d5a008173d46 schema:name nlm_unique_id
154 schema:value 101090633
155 rdf:type schema:PropertyValue
156 N4459c68d1ca1416ba541c862b9cb5622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Protein Kinase Inhibitors
158 rdf:type schema:DefinedTerm
159 N56ace0d253db44eabfd78a1f5c3f6d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Smoking
161 rdf:type schema:DefinedTerm
162 N5ad74739d6d34bae89921f7047a52aa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Lung
164 rdf:type schema:DefinedTerm
165 N5f4a1e648931478094c2e653cd9706af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 N644223d8f296455da358b5ee3757c7f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Epithelial Cells
170 rdf:type schema:DefinedTerm
171 N66292c78fa874c2fa60e2501399bb7f2 schema:volumeNumber 12
172 rdf:type schema:PublicationVolume
173 N6ac986e688d349d5b0e58dc9f1a9cc31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Male
175 rdf:type schema:DefinedTerm
176 N7093d6cefd9345d698aca76121d1ee20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name p38 Mitogen-Activated Protein Kinases
178 rdf:type schema:DefinedTerm
179 N7114e234f38c413398435f863e5b163d schema:name dimensions_id
180 schema:value pub.1031468272
181 rdf:type schema:PropertyValue
182 N7dad61e4694344d5a768f1f168142f98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name DNA Damage
184 rdf:type schema:DefinedTerm
185 N84a047f6bdec4f18a6d95e7f34ff77fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Analysis of Variance
187 rdf:type schema:DefinedTerm
188 N88198fb6e2bf4b33831d29dc645367ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cellular Senescence
190 rdf:type schema:DefinedTerm
191 N8b8574142fb24f5a9e7b461e13cc7569 rdf:first sg:person.01167315617.12
192 rdf:rest N094531d6451b45a186a0ce6fc8526e7c
193 N8da62ac534084e0fb9bed412793a10e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Pneumonia
195 rdf:type schema:DefinedTerm
196 N93d3f56c77ac45c3987413a9ac80da53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Aged
198 rdf:type schema:DefinedTerm
199 Nb2a6fd2c43d246d18f9a7e6a388ec689 rdf:first sg:person.0675132611.11
200 rdf:rest Nca0e431904614bd890491d3f999fb0ee
201 Nbd8299e444004ad58fa3a4376768e881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Respiratory Mucosa
203 rdf:type schema:DefinedTerm
204 Nc894b32eb3e541b0840bb2fd990e5014 schema:name Springer Nature - SN SciGraph project
205 rdf:type schema:Organization
206 Nca0e431904614bd890491d3f999fb0ee rdf:first sg:person.01170672336.21
207 rdf:rest N8b8574142fb24f5a9e7b461e13cc7569
208 Nd4e35b74b06a4429a7943de0cb269660 schema:name readcube_id
209 schema:value 95e862f3c708814369785b409636e341848033a38726b7b9013cac89b953f371
210 rdf:type schema:PropertyValue
211 Nd52e8b8a52e74b6b95518f0fadff5d34 schema:name doi
212 schema:value 10.1186/1465-9921-12-78
213 rdf:type schema:PropertyValue
214 Nda2d08625e424929a5a477c5d20e6967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Cell Proliferation
216 rdf:type schema:DefinedTerm
217 Ndadbaaa079ec45909a5d055bfe232d4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Enzyme Activation
219 rdf:type schema:DefinedTerm
220 Ndd0c87133ef04df1bb303f78de8eca21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Female
222 rdf:type schema:DefinedTerm
223 Ndf0cc23bc2f346d599af4b53cbd32862 schema:name pubmed_id
224 schema:value 21663649
225 rdf:type schema:PropertyValue
226 Ne3e00b8c56d14b2798aa02ba70b57a07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Disease Models, Animal
228 rdf:type schema:DefinedTerm
229 Ne47a01ef85354e0aa48832640d40671b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Cell Line, Tumor
231 rdf:type schema:DefinedTerm
232 Ne6d5572d25014b5c95627136ca65d48e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Cytokines
234 rdf:type schema:DefinedTerm
235 Nf4541b21821044d99e0147bbff0b0677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Naphthalenes
237 rdf:type schema:DefinedTerm
238 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
239 schema:name Medical and Health Sciences
240 rdf:type schema:DefinedTerm
241 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
242 schema:name Cardiorespiratory Medicine and Haematology
243 rdf:type schema:DefinedTerm
244 sg:journal.1028525 schema:issn 1465-9921
245 1465-993X
246 schema:name Respiratory Research
247 rdf:type schema:Periodical
248 sg:person.01167315617.12 schema:affiliation https://www.grid.ac/institutes/grid.410818.4
249 schema:familyName Nagai
250 schema:givenName Atsushi
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167315617.12
252 rdf:type schema:Person
253 sg:person.01170672336.21 schema:affiliation https://www.grid.ac/institutes/grid.410818.4
254 schema:familyName Onizawa
255 schema:givenName Shigemitsu
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170672336.21
257 rdf:type schema:Person
258 sg:person.01352423511.39 schema:affiliation https://www.grid.ac/institutes/grid.410818.4
259 schema:familyName Aoshiba
260 schema:givenName Kazutetsu
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352423511.39
262 rdf:type schema:Person
263 sg:person.0675132611.11 schema:affiliation https://www.grid.ac/institutes/grid.410818.4
264 schema:familyName Zhou
265 schema:givenName Fang
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675132611.11
267 rdf:type schema:Person
268 sg:pub.10.1007/978-1-4419-7002-2_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017081238
269 https://doi.org/10.1007/978-1-4419-7002-2_10
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s10555-010-9220-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021410177
272 https://doi.org/10.1007/s10555-010-9220-9
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/leu.2010.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003315718
275 https://doi.org/10.1038/leu.2010.6
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nature05529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011710145
278 https://doi.org/10.1038/nature05529
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/ncb1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008470674
281 https://doi.org/10.1038/ncb1909
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nrc2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030184692
284 https://doi.org/10.1038/nrc2560
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nrm2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030616797
287 https://doi.org/10.1038/nrm2233
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/onc.2009.318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026912786
290 https://doi.org/10.1038/onc.2009.318
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/1465-9921-7-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041806353
293 https://doi.org/10.1186/1465-9921-7-32
294 rdf:type schema:CreativeWork
295 sg:pub.10.1186/1742-4933-3-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049271636
296 https://doi.org/10.1186/1742-4933-3-4
297 rdf:type schema:CreativeWork
298 sg:pub.10.1186/1742-4933-5-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027612736
299 https://doi.org/10.1186/1742-4933-5-5
300 rdf:type schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1075203260 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1081858248 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1082801809 schema:CreativeWork
304 https://doi.org/10.1016/0165-1110(91)90007-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1007409248
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2005.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049061900
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.cell.2008.03.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026622054
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.cell.2008.03.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029924676
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.cell.2008.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051432284
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.cell.2008.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015334998
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.ijrobp.2009.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017164844
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.molmed.2010.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033625660
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.rmed.2008.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028401622
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.yexcr.2004.10.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046273413
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0960-9822(99)80420-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029074185
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0968-0004(00)01595-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027739512
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s1074-5521(97)90194-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018287057
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1055/s-0030-1254066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057219415
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.89.10.4683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772207
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/oxfordjournals.jbchem.a022549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059961350
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1111/j.1474-9726.2009.00481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010470243
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1124/jpet.107.127092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052864400
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1146/annurev.bi.57.070188.002025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014574790
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1152/ajplung.00024.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003212310
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1152/ajplung.1995.269.6.l791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082864420
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1152/ajplung.1995.269.6.l800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082864421
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1152/ajplung.1997.272.1.l28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083048441
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1152/japplphysiol.01150.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034777220
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1159/000268287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000440407
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1164/rccm.200509-1374oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1029524812
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1164/rccm.200809-1398oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1019542810
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1165/rcmb.2003-0290oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1026800122
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1165/rcmb.2008-0353oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1011863730
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1177/002215549904700612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014542315
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1183/09031936.00036707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033834799
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1183/09031936.06.00087005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047686569
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1378/chest.08-1419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029794002
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1513/pats.200904-017rm schema:sameAs https://app.dimensions.ai/details/publication/pub.1014591325
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1513/pats.200907-078rm schema:sameAs https://app.dimensions.ai/details/publication/pub.1023158009
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1634/stemcells.2008-0299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004239319
375 rdf:type schema:CreativeWork
376 https://doi.org/10.4049/jimmunol.178.10.6504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077412744
377 rdf:type schema:CreativeWork
378 https://doi.org/10.4061/2010/390791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021549849
379 rdf:type schema:CreativeWork
380 https://www.grid.ac/institutes/grid.410818.4 schema:alternateName Tokyo Women's Medical University
381 schema:name First Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan
382 Pulmonary Division, Graduate School of Medical Science, Tokyo Women's Medical University, 8-1 Kawada-cho, 162-8666, Shinjuku-ku, Tokyo, Japan
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...