Ontology type: schema:ScholarlyArticle Open Access: True
2010-12
AUTHORSChyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau, Wen-Harn Pan
ABSTRACTBACKGROUND: The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT)(n) repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. METHODS: A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke patients were screened for the length of (GT)(n) repeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and <==26, respectively. RESULTS: Stroke patients tended to have more proportions of hypertension, diabetics and genotype L, than those of genotype S. Patients with genotype L of HO-1 gene promoter have higher stroke risk in comparison with genotype S especially in dyslipidemia individuals. The significant differences on stroke risk in multivariate odds ratios were found especially in people with low HDL-C levels. CONCLUSIONS: Subjects carrying longer (GT)(n) repeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status. More... »
PAGES12
http://scigraph.springernature.com/pub.10.1186/1423-0127-17-12
DOIhttp://dx.doi.org/10.1186/1423-0127-17-12
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20175935
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"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186/1423-0127-17-12"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1423-0127-17-12'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1423-0127-17-12'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1423-0127-17-12'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1423-0127-17-12'
This table displays all metadata directly associated to this object as RDF triples.
309 TRIPLES
21 PREDICATES
86 URIs
36 LITERALS
24 BLANK NODES