Genetic Clinical Markers of Human Neuroblastoma with Special Reference to N-myc Oncogene: Amplified or Not Amplified? – An Overview View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996

AUTHORS

Yoshiaki Tsuchida, Hiromichi Hemmi, Akira Inoue, Kazuko Obana, Hong-Wei Yang, Yasuhide Hayashi, Naotoshi Kanda, Hiroyuki Shimatake

ABSTRACT

Neuroblastoma is the most common extracranial tumor in children, and cytogenetically, chromosome 1p deletions, extrachromosomal double minutes, and homogeneously staining regions (HSRs) are commonly observed in cell lines and in tumors in advanced stages. It is found that an HSR represents genomic amplification of N-myc, which plays a key role in determining the aggressiveness of neuroblastoma. However, stage IV neuroblastomas or cell lines which lack N-myc amplification are also progressive, and some of them show evidence of N-myc expression in terms of mRNA and/or N-Myc oncoprotein. It was recently shown that a small proximal locus mapped between 1p35-36.1 and 1p36.23 may function as a suppressor gene of N-myc amplification. In neuroblastoma, a pattern of diploidy is associated with rapid tumor growth and poor survival. Expression of bcl-2 proto-oncogene is strongly associated with unfavorable histology, while expressions of Ha-ras and trk-A proto-oncogenes indicate a favorable prognosis. trk-A proto-oncogene encodes a receptor for nerve growth factor. Genetic characteristics of neuroblastomas found by urinary catecholamine mass screening are also discussed. More... »

PAGES

65-74

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1159/000217968

DOI

http://dx.doi.org/10.1159/000217968

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028117843

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8658015


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