Mutational Analysis of the β-Catenin Gene in Gastric Carcinomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12-15

AUTHORS

Yasushi Sasaki, Ichiro Morimoto, Masanobu Kusano, Masao Hosokawa, Fumio Itoh, Kazuyoshi Yanagihara, Kohzoh Imai, Takashi Tokino

ABSTRACT

Previous studies reported that mutation of the adenomatous polyposis coli (APC) gene was not observed in the majority of gastric cancers. To evaluate the role of the APC/beta-catenin/Tcf pathway, we analyzed mutations in the beta-catenin gene and the accumulation of beta-catenin protein in gastric carcinomas. An interstitial deletion spanning exon 3 of the beta-catenin gene was observed in 1 of 13 gastric cancer cell lines. No missense mutation was found in these 13 cell lines. Nuclear and/or cytoplasmic localization of beta-catenin was observed in 16 of 70 primary gastric carcinomas by immunohistochemistry, while we found no mutations in exon 3 in 35 carcinoma tissues available for PCR amplification. Our findings suggest that somatic mutations of the beta-catenin gene are rare in human gastric carcinomas and that accumulation of normal beta-catenin protein in a subset of gastric cancers may be due to other mechanisms of its activation. More... »

PAGES

123-130

Identifiers

URI

http://scigraph.springernature.com/pub.10.1159/000050606

DOI

http://dx.doi.org/10.1159/000050606

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024519784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11125285


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