Evaluation of Serum Alkaline DNase Activity in Treatment Monitoring of Head and Neck Cancer Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000

AUTHORS

Prabhudas S. Patel, Beena P. Patel, Rakesh M. Rawal, Gira N. Raval, Mintoo M. Patel, Jayendra B. Patel, Franky P. Jha, Devendra D. Patel

ABSTRACT

Our previously published data on breast cancer suggest that serum alkaline DNase, a known circulating tumour marker, can be used for treatment monitoring of cancer patients. Serum alkaline DNase activities were analyzed in 215 untreated head and neck cancer patients. The enzyme activity ranged from 0.17 to 97.97 IKU/l in untreated cancer patients. Responders (n = 314) showed significantly elevated activity of alkaline DNase as compared to untreated cancer patients (p < 0.001). While non-responders (n = 168) showed comparable activity with untreated cancer patients. Serum alkaline DNase activities were significantly elevated in responders as compared to non-responders (p < 0.001). Our clinical studies during follow-up of patients indicated that the variations in serum alkaline DNase activities in individual patients correlate closely with response to therapy. Serum alkaline DNase also appeared to be useful in predicting treatment response in the long-term follow-up of patients. Serum alkaline DNase was systematically examined as a possible indicator for recurrence in patients under complete remission. In conclusion, serum alkaline DNase may be useful as a treatment monitoring in patients with head and neck malignancies. More... »

PAGES

82-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1159/000030113

DOI

http://dx.doi.org/10.1159/000030113

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033769004

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10686537


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laryngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monitoring, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Prabhudas S.", 
        "id": "sg:person.014435437552.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014435437552.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Beena P.", 
        "id": "sg:person.01234257727.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234257727.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rawal", 
        "givenName": "Rakesh M.", 
        "id": "sg:person.016041653217.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016041653217.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raval", 
        "givenName": "Gira N.", 
        "id": "sg:person.0727544412.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727544412.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Mintoo M.", 
        "id": "sg:person.01347561053.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347561053.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Jayendra B.", 
        "id": "sg:person.016513270022.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016513270022.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jha", 
        "givenName": "Franky P.", 
        "id": "sg:person.01054414210.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054414210.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gujarat Cancer & Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.418345.f", 
          "name": [
            "Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Devendra D.", 
        "id": "sg:person.010604465262.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010604465262.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00001622-199206000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005151576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001622-199206000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005151576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(88)90225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013311069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910430538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016245961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001622-199709030-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019042862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001622-199709030-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019042862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0964-1955(94)90046-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020922698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(92)90352-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022066394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(92)90352-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022066394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19810201)47:3<523::aid-cncr2820470316>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024500046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02773731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025012155", 
          "https://doi.org/10.1007/bf02773731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(89)90128-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025461136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(89)90128-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025461136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869009126538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027974167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.9.7288160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.9.7288160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90103-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039858956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044537005", 
          "https://doi.org/10.1007/bf00262404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044537005", 
          "https://doi.org/10.1007/bf00262404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19880501)61:9<1838::aid-cncr2820610920>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048347733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074890304", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079409627", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079766938", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089168507100602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080119180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089168507100602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080119180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080691419", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082295161", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082748766", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895703", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089701200204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083163592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089701200204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083163592"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000", 
    "datePublishedReg": "2000-01-01", 
    "description": "Our previously published data on breast cancer suggest that serum alkaline DNase, a known circulating tumour marker, can be used for treatment monitoring of cancer patients. Serum alkaline DNase activities were analyzed in 215 untreated head and neck cancer patients. The enzyme activity ranged from 0.17 to 97.97 IKU/l in untreated cancer patients. Responders (n = 314) showed significantly elevated activity of alkaline DNase as compared to untreated cancer patients (p < 0.001). While non-responders (n = 168) showed comparable activity with untreated cancer patients. Serum alkaline DNase activities were significantly elevated in responders as compared to non-responders (p < 0.001). Our clinical studies during follow-up of patients indicated that the variations in serum alkaline DNase activities in individual patients correlate closely with response to therapy. Serum alkaline DNase also appeared to be useful in predicting treatment response in the long-term follow-up of patients. Serum alkaline DNase was systematically examined as a possible indicator for recurrence in patients under complete remission. In conclusion, serum alkaline DNase may be useful as a treatment monitoring in patients with head and neck malignancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1159/000030113", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091981", 
        "issn": [
          "1010-4283", 
          "1423-0380"
        ], 
        "name": "Tumor Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Evaluation of Serum Alkaline DNase Activity in Treatment Monitoring of Head and Neck Cancer Patients", 
    "pagination": "82-89", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a0dd00c71c649c26989bea66b7656e086607be6960d8603beaac5ac62484563e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10686537"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409922"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1159/000030113"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033769004"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1159/000030113", 
      "https://app.dimensions.ai/details/publication/pub.1033769004"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000527.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.karger.com/?doi=000030113"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1159/000030113'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1159/000030113'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1159/000030113'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1159/000030113'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      70 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1159/000030113 schema:about N196864f0a43d4f9b9d42f5b2609b1624
2 N1f1606271e224c35a8dd82920935f5cf
3 N44f0cd95b23f4fcdb003dd5dfc0f778d
4 N4aefcb3de55a4407acd23ff584fd7b2a
5 N4b505a7c389946f28bd3a9400a0cbc9c
6 N56472dc444da4c8384623111d3c3b0a7
7 N595b1f6fe22d4371aa0bd33f13a4aa84
8 N6be7d841dcee4ec5b9fa8c23300f1a36
9 N7e7b54ffc3ea4cfdaf90388f1b87bfdb
10 N971fbffde4164ae18eb841299570598b
11 N9735f7a08b8c4adbaef52642e00a6903
12 N9ef0cd28ec66422098e799ac129735f5
13 Na26a91b5241a47aeb0c5c562d46dc0e6
14 Na9ec5550616b42f381585fa7bf051f28
15 Nad44c6d5f3094018a5ff6deb33955e02
16 Nbab8d032da10445bb392bac175b925e3
17 Neea990d4904b4034818439eaf2ac1942
18 Nf8983530f39549e8b95742ecd07b0345
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N4ac6da98f1d2424d900c004a143a58c4
22 schema:citation sg:pub.10.1007/bf00262404
23 sg:pub.10.1007/bf02773731
24 https://app.dimensions.ai/details/publication/pub.1074890304
25 https://app.dimensions.ai/details/publication/pub.1079409627
26 https://app.dimensions.ai/details/publication/pub.1079766938
27 https://app.dimensions.ai/details/publication/pub.1080691419
28 https://app.dimensions.ai/details/publication/pub.1082295161
29 https://app.dimensions.ai/details/publication/pub.1082748766
30 https://app.dimensions.ai/details/publication/pub.1082895703
31 https://doi.org/10.1002/1097-0142(19810201)47:3<523::aid-cncr2820470316>3.0.co;2-r
32 https://doi.org/10.1002/1097-0142(19880501)61:9<1838::aid-cncr2820610920>3.0.co;2-r
33 https://doi.org/10.1002/ijc.2910430538
34 https://doi.org/10.1016/0009-8981(89)90128-9
35 https://doi.org/10.1016/0009-8981(92)90352-q
36 https://doi.org/10.1016/0277-5379(88)90225-8
37 https://doi.org/10.1016/0277-5379(91)90103-k
38 https://doi.org/10.1016/0964-1955(94)90046-9
39 https://doi.org/10.1097/00001622-199206000-00008
40 https://doi.org/10.1097/00001622-199709030-00006
41 https://doi.org/10.1177/030089168507100602
42 https://doi.org/10.1177/172460089701200204
43 https://doi.org/10.1177/29.9.7288160
44 https://doi.org/10.3109/02841869009126538
45 schema:datePublished 2000
46 schema:datePublishedReg 2000-01-01
47 schema:description Our previously published data on breast cancer suggest that serum alkaline DNase, a known circulating tumour marker, can be used for treatment monitoring of cancer patients. Serum alkaline DNase activities were analyzed in 215 untreated head and neck cancer patients. The enzyme activity ranged from 0.17 to 97.97 IKU/l in untreated cancer patients. Responders (n = 314) showed significantly elevated activity of alkaline DNase as compared to untreated cancer patients (p < 0.001). While non-responders (n = 168) showed comparable activity with untreated cancer patients. Serum alkaline DNase activities were significantly elevated in responders as compared to non-responders (p < 0.001). Our clinical studies during follow-up of patients indicated that the variations in serum alkaline DNase activities in individual patients correlate closely with response to therapy. Serum alkaline DNase also appeared to be useful in predicting treatment response in the long-term follow-up of patients. Serum alkaline DNase was systematically examined as a possible indicator for recurrence in patients under complete remission. In conclusion, serum alkaline DNase may be useful as a treatment monitoring in patients with head and neck malignancies.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N6a927ef54aaa4a9b98bf51a6f7d676eb
52 Ne2abb35f75244e40b1f2f3b739c0cd34
53 sg:journal.1091981
54 schema:name Evaluation of Serum Alkaline DNase Activity in Treatment Monitoring of Head and Neck Cancer Patients
55 schema:pagination 82-89
56 schema:productId N037131deaac2479d983e9764df932c31
57 Nc55e5b9d5eca412f9c0d32cd8ce7a730
58 Nc6676a3dcc8146eaa4be2f404370cbd8
59 Ncaa30d17c1fd4c39a73f2cfe54f85d64
60 Nde59b455507f46ad8f91117dafa7514b
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033769004
62 https://doi.org/10.1159/000030113
63 schema:sdDatePublished 2019-04-11T00:19
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N034dee55cbf24780ae11f910b4c849f9
66 schema:url https://www.karger.com/?doi=000030113
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N034dee55cbf24780ae11f910b4c849f9 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N037131deaac2479d983e9764df932c31 schema:name pubmed_id
73 schema:value 10686537
74 rdf:type schema:PropertyValue
75 N196864f0a43d4f9b9d42f5b2609b1624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Head and Neck Neoplasms
77 rdf:type schema:DefinedTerm
78 N1f1606271e224c35a8dd82920935f5cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Male
80 rdf:type schema:DefinedTerm
81 N23e98afb2a594e2a9252129893787437 rdf:first sg:person.016041653217.97
82 rdf:rest Ne412ab94fca042c29cbbbd185e60fed5
83 N44f0cd95b23f4fcdb003dd5dfc0f778d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Laryngeal Neoplasms
85 rdf:type schema:DefinedTerm
86 N4ac6da98f1d2424d900c004a143a58c4 rdf:first sg:person.014435437552.37
87 rdf:rest N7f68459ae2284b1ba73297573adbfc96
88 N4aefcb3de55a4407acd23ff584fd7b2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Monitoring, Physiologic
90 rdf:type schema:DefinedTerm
91 N4b505a7c389946f28bd3a9400a0cbc9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Neoplasm Staging
93 rdf:type schema:DefinedTerm
94 N56472dc444da4c8384623111d3c3b0a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Prognosis
96 rdf:type schema:DefinedTerm
97 N57675953692448248399efded4601915 rdf:first sg:person.010604465262.96
98 rdf:rest rdf:nil
99 N595b1f6fe22d4371aa0bd33f13a4aa84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Carcinoma, Squamous Cell
101 rdf:type schema:DefinedTerm
102 N6a927ef54aaa4a9b98bf51a6f7d676eb schema:issueNumber 2
103 rdf:type schema:PublicationIssue
104 N6be7d841dcee4ec5b9fa8c23300f1a36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Adolescent
106 rdf:type schema:DefinedTerm
107 N7405e9dd71d44969b000098e67306e83 rdf:first sg:person.01054414210.61
108 rdf:rest N57675953692448248399efded4601915
109 N7e7b54ffc3ea4cfdaf90388f1b87bfdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adult
111 rdf:type schema:DefinedTerm
112 N7f68459ae2284b1ba73297573adbfc96 rdf:first sg:person.01234257727.00
113 rdf:rest N23e98afb2a594e2a9252129893787437
114 N971fbffde4164ae18eb841299570598b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Deoxyribonucleases
116 rdf:type schema:DefinedTerm
117 N9735f7a08b8c4adbaef52642e00a6903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Middle Aged
119 rdf:type schema:DefinedTerm
120 N9ef0cd28ec66422098e799ac129735f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mouth Neoplasms
122 rdf:type schema:DefinedTerm
123 Na26a91b5241a47aeb0c5c562d46dc0e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Aged
125 rdf:type schema:DefinedTerm
126 Na9c7fee26f8e45a49926d5cd7d65cc85 rdf:first sg:person.01347561053.42
127 rdf:rest Ncacd1704e2e34304850b6e74f5b3c27e
128 Na9ec5550616b42f381585fa7bf051f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Biomarkers, Tumor
130 rdf:type schema:DefinedTerm
131 Nad44c6d5f3094018a5ff6deb33955e02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Nbab8d032da10445bb392bac175b925e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Recurrence
136 rdf:type schema:DefinedTerm
137 Nc55e5b9d5eca412f9c0d32cd8ce7a730 schema:name dimensions_id
138 schema:value pub.1033769004
139 rdf:type schema:PropertyValue
140 Nc6676a3dcc8146eaa4be2f404370cbd8 schema:name readcube_id
141 schema:value a0dd00c71c649c26989bea66b7656e086607be6960d8603beaac5ac62484563e
142 rdf:type schema:PropertyValue
143 Ncaa30d17c1fd4c39a73f2cfe54f85d64 schema:name nlm_unique_id
144 schema:value 8409922
145 rdf:type schema:PropertyValue
146 Ncacd1704e2e34304850b6e74f5b3c27e rdf:first sg:person.016513270022.63
147 rdf:rest N7405e9dd71d44969b000098e67306e83
148 Nde59b455507f46ad8f91117dafa7514b schema:name doi
149 schema:value 10.1159/000030113
150 rdf:type schema:PropertyValue
151 Ne2abb35f75244e40b1f2f3b739c0cd34 schema:volumeNumber 21
152 rdf:type schema:PublicationVolume
153 Ne412ab94fca042c29cbbbd185e60fed5 rdf:first sg:person.0727544412.84
154 rdf:rest Na9c7fee26f8e45a49926d5cd7d65cc85
155 Neea990d4904b4034818439eaf2ac1942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 Nf8983530f39549e8b95742ecd07b0345 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Pharyngeal Neoplasms
160 rdf:type schema:DefinedTerm
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
165 schema:name Oncology and Carcinogenesis
166 rdf:type schema:DefinedTerm
167 sg:journal.1091981 schema:issn 1010-4283
168 1423-0380
169 schema:name Tumor Biology
170 rdf:type schema:Periodical
171 sg:person.01054414210.61 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
172 schema:familyName Jha
173 schema:givenName Franky P.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054414210.61
175 rdf:type schema:Person
176 sg:person.010604465262.96 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
177 schema:familyName Patel
178 schema:givenName Devendra D.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010604465262.96
180 rdf:type schema:Person
181 sg:person.01234257727.00 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
182 schema:familyName Patel
183 schema:givenName Beena P.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234257727.00
185 rdf:type schema:Person
186 sg:person.01347561053.42 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
187 schema:familyName Patel
188 schema:givenName Mintoo M.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347561053.42
190 rdf:type schema:Person
191 sg:person.014435437552.37 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
192 schema:familyName Patel
193 schema:givenName Prabhudas S.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014435437552.37
195 rdf:type schema:Person
196 sg:person.016041653217.97 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
197 schema:familyName Rawal
198 schema:givenName Rakesh M.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016041653217.97
200 rdf:type schema:Person
201 sg:person.016513270022.63 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
202 schema:familyName Patel
203 schema:givenName Jayendra B.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016513270022.63
205 rdf:type schema:Person
206 sg:person.0727544412.84 schema:affiliation https://www.grid.ac/institutes/grid.418345.f
207 schema:familyName Raval
208 schema:givenName Gira N.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727544412.84
210 rdf:type schema:Person
211 sg:pub.10.1007/bf00262404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044537005
212 https://doi.org/10.1007/bf00262404
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/bf02773731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025012155
215 https://doi.org/10.1007/bf02773731
216 rdf:type schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1074890304 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1079409627 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079766938 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1080691419 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1082295161 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1082748766 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082895703 schema:CreativeWork
224 https://doi.org/10.1002/1097-0142(19810201)47:3<523::aid-cncr2820470316>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1024500046
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/1097-0142(19880501)61:9<1838::aid-cncr2820610920>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1048347733
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/ijc.2910430538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016245961
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0009-8981(89)90128-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025461136
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0009-8981(92)90352-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1022066394
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0277-5379(88)90225-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013311069
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0277-5379(91)90103-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1039858956
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0964-1955(94)90046-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020922698
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/00001622-199206000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005151576
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/00001622-199709030-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019042862
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1177/030089168507100602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080119180
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1177/172460089701200204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083163592
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1177/29.9.7288160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030503016
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3109/02841869009126538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027974167
251 rdf:type schema:CreativeWork
252 https://www.grid.ac/institutes/grid.418345.f schema:alternateName Gujarat Cancer & Research Institute
253 schema:name Biochemistry Research Division, Department of Cancer Biology, and, Department of Surgical Oncology (Speciality Clinic), The Gujarat Cancer and Research Institute, Ahmedabad, India
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...