Ontology type: schema:ScholarlyArticle
1998-07-06
AUTHORSKazuhisa Taketa, Kozue Kamakura, Shinji Satomura, Hiroko Taga
ABSTRACTThe effect of lentil lectin (LCA) on the binding of mouse monoclonal antibody (MoAb) against human alpha-fetoprotein (AFP) to LCA-nonreactive AFP-L1 and LCA-reactive AFP-L3 was studied on a panel of 30 MoAbs provided by the TD-2 Workshop of ISOBM for epitope mapping. LCA inhibited the binding of MoAbs 93 and 98 to AFP-L3 but not to AFP-L1, indicating that there was a competition between the MoAbs and LCA for the AFP sugar chain. With MoAbs 100, 109, 118, and 120, LCA rather increased the binding to AFP-L3 over that to AFP-L1. These modulating effects of LCA on the MoAb binding to AFP-L3 were abolished by periodate treatment of the AFP preparations without affecting the binding of MoAb to AFP. Concanavalin A had similar inhibiting and enhancing effects on MoAb binding, but equally to AFP-L1 and AFP-L3, both of which are fully reactive with concanavalin A. The results suggested that MoAbs 93 and 98 recognized epitopes closely related to sugar chain, and their binding to AFP-L3 was inhibited by the bound LCA due to steric hindrance. The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction. More... »
PAGES318-328
http://scigraph.springernature.com/pub.10.1159/000030024
DOIhttp://dx.doi.org/10.1159/000030024
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031800140
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9679744
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Concanavalin A",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epitope Mapping",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lectins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plant Lectins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Conformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "alpha-Fetoproteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Taketa",
"givenName": "Kazuhisa",
"id": "sg:person.01235025162.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235025162.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kamakura",
"givenName": "Kozue",
"id": "sg:person.01200436470.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200436470.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Satomura",
"givenName": "Shinji",
"id": "sg:person.01010774023.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010774023.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Taga",
"givenName": "Hiroko",
"id": "sg:person.01057365017.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057365017.14"
],
"type": "Person"
}
],
"datePublished": "1998-07-06",
"datePublishedReg": "1998-07-06",
"description": "The effect of lentil lectin (LCA) on the binding of mouse monoclonal antibody (MoAb) against human alpha-fetoprotein (AFP) to LCA-nonreactive AFP-L1 and LCA-reactive AFP-L3 was studied on a panel of 30 MoAbs provided by the TD-2 Workshop of ISOBM for epitope mapping. LCA inhibited the binding of MoAbs 93 and 98 to AFP-L3 but not to AFP-L1, indicating that there was a competition between the MoAbs and LCA for the AFP sugar chain. With MoAbs 100, 109, 118, and 120, LCA rather increased the binding to AFP-L3 over that to AFP-L1. These modulating effects of LCA on the MoAb binding to AFP-L3 were abolished by periodate treatment of the AFP preparations without affecting the binding of MoAb to AFP. Concanavalin A had similar inhibiting and enhancing effects on MoAb binding, but equally to AFP-L1 and AFP-L3, both of which are fully reactive with concanavalin A. The results suggested that MoAbs 93 and 98 recognized epitopes closely related to sugar chain, and their binding to AFP-L3 was inhibited by the bound LCA due to steric hindrance. The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction.",
"genre": "article",
"id": "sg:pub.10.1159/000030024",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1091981",
"issn": [
"1010-4283",
"1423-0380"
],
"name": "Tumor Biology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "19"
}
],
"keywords": [
"alpha-fetoprotein",
"AFP-L3",
"AFP-L1",
"human alpha-fetoprotein",
"monoclonal antibodies",
"binding of MoAbs",
"concanavalin A",
"AFP sugar chain",
"mouse monoclonal antibody",
"MoAb",
"modulating effect",
"periodate treatment",
"epitope mapping",
"antibodies",
"sugar chains",
"concanavalin A.",
"enhanced binding",
"AFP preparations",
"lentil lectin",
"binding",
"epitopes",
"treatment",
"effect",
"inhibiting",
"lectin",
"allosteric mechanism",
"modulation",
"L3",
"A.",
"panel",
"mechanism",
"glycoforms",
"LCA",
"L1",
"preparation",
"interaction",
"results",
"workshop",
"chain",
"mapping",
"hindrance",
"steric hindrance",
"competition"
],
"name": "Lectin-Dependent Modulation of Interaction between Human Alpha-Fetoprotein and Its Monoclonal Antibodies",
"pagination": "318-328",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031800140"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1159/000030024"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"9679744"
]
}
],
"sameAs": [
"https://doi.org/10.1159/000030024",
"https://app.dimensions.ai/details/publication/pub.1031800140"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_265.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1159/000030024"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1159/000030024'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1159/000030024'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1159/000030024'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1159/000030024'
This table displays all metadata directly associated to this object as RDF triples.
170 TRIPLES
21 PREDICATES
80 URIs
72 LITERALS
18 BLANK NODES