Lectin-Dependent Modulation of Interaction between Human Alpha-Fetoprotein and Its Monoclonal Antibodies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-07-06

AUTHORS

Kazuhisa Taketa, Kozue Kamakura, Shinji Satomura, Hiroko Taga

ABSTRACT

The effect of lentil lectin (LCA) on the binding of mouse monoclonal antibody (MoAb) against human alpha-fetoprotein (AFP) to LCA-nonreactive AFP-L1 and LCA-reactive AFP-L3 was studied on a panel of 30 MoAbs provided by the TD-2 Workshop of ISOBM for epitope mapping. LCA inhibited the binding of MoAbs 93 and 98 to AFP-L3 but not to AFP-L1, indicating that there was a competition between the MoAbs and LCA for the AFP sugar chain. With MoAbs 100, 109, 118, and 120, LCA rather increased the binding to AFP-L3 over that to AFP-L1. These modulating effects of LCA on the MoAb binding to AFP-L3 were abolished by periodate treatment of the AFP preparations without affecting the binding of MoAb to AFP. Concanavalin A had similar inhibiting and enhancing effects on MoAb binding, but equally to AFP-L1 and AFP-L3, both of which are fully reactive with concanavalin A. The results suggested that MoAbs 93 and 98 recognized epitopes closely related to sugar chain, and their binding to AFP-L3 was inhibited by the bound LCA due to steric hindrance. The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction. More... »

PAGES

318-328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1159/000030024

DOI

http://dx.doi.org/10.1159/000030024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031800140

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9679744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Concanavalin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitope Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lectins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Lectins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Fetoproteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taketa", 
        "givenName": "Kazuhisa", 
        "id": "sg:person.01235025162.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235025162.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamakura", 
        "givenName": "Kozue", 
        "id": "sg:person.01200436470.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200436470.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satomura", 
        "givenName": "Shinji", 
        "id": "sg:person.01010774023.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010774023.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taga", 
        "givenName": "Hiroko", 
        "id": "sg:person.01057365017.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057365017.14"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-07-06", 
    "datePublishedReg": "1998-07-06", 
    "description": "The effect of lentil lectin (LCA) on the binding of mouse monoclonal antibody (MoAb) against human alpha-fetoprotein (AFP) to LCA-nonreactive AFP-L1 and LCA-reactive AFP-L3 was studied on a panel of 30 MoAbs provided by the TD-2 Workshop of ISOBM for epitope mapping. LCA inhibited the binding of MoAbs 93 and 98 to AFP-L3 but not to AFP-L1, indicating that there was a competition between the MoAbs and LCA for the AFP sugar chain. With MoAbs 100, 109, 118, and 120, LCA rather increased the binding to AFP-L3 over that to AFP-L1. These modulating effects of LCA on the MoAb binding to AFP-L3 were abolished by periodate treatment of the AFP preparations without affecting the binding of MoAb to AFP. Concanavalin A had similar inhibiting and enhancing effects on MoAb binding, but equally to AFP-L1 and AFP-L3, both of which are fully reactive with concanavalin A. The results suggested that MoAbs 93 and 98 recognized epitopes closely related to sugar chain, and their binding to AFP-L3 was inhibited by the bound LCA due to steric hindrance. The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction.", 
    "genre": "article", 
    "id": "sg:pub.10.1159/000030024", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091981", 
        "issn": [
          "1010-4283", 
          "1423-0380"
        ], 
        "name": "Tumor Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "alpha-fetoprotein", 
      "AFP-L3", 
      "AFP-L1", 
      "human alpha-fetoprotein", 
      "monoclonal antibodies", 
      "binding of MoAbs", 
      "concanavalin A", 
      "AFP sugar chain", 
      "mouse monoclonal antibody", 
      "MoAb", 
      "modulating effect", 
      "periodate treatment", 
      "epitope mapping", 
      "antibodies", 
      "sugar chains", 
      "concanavalin A.", 
      "enhanced binding", 
      "AFP preparations", 
      "lentil lectin", 
      "binding", 
      "epitopes", 
      "treatment", 
      "effect", 
      "inhibiting", 
      "lectin", 
      "allosteric mechanism", 
      "modulation", 
      "L3", 
      "A.", 
      "panel", 
      "mechanism", 
      "glycoforms", 
      "LCA", 
      "L1", 
      "preparation", 
      "interaction", 
      "results", 
      "workshop", 
      "chain", 
      "mapping", 
      "hindrance", 
      "steric hindrance", 
      "competition"
    ], 
    "name": "Lectin-Dependent Modulation of Interaction between Human Alpha-Fetoprotein and Its Monoclonal Antibodies", 
    "pagination": "318-328", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031800140"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1159/000030024"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9679744"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1159/000030024", 
      "https://app.dimensions.ai/details/publication/pub.1031800140"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_265.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1159/000030024"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1159/000030024'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1159/000030024'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1159/000030024'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1159/000030024'


 

This table displays all metadata directly associated to this object as RDF triples.

170 TRIPLES      21 PREDICATES      80 URIs      72 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1159/000030024 schema:about N1d89e9402a634e14817a6e4b6d78bafa
2 N1e3175061f4c40e8a6d33c0db7e0373e
3 N20d7ea14366a426b8c4fc4b373c08118
4 N2a6cdf9255d04ae190a8792e48b45685
5 N3f95d109ff1245be9de5c23ef275a056
6 N4256a80dae2f4b87b819dc2546f28706
7 N72b533bb846d41c298880e242390d5ac
8 N87bf007d75f34e4ebe1d0749bd130e2d
9 Nbf587d400bd84035a986ae67d85063b0
10 Nc3ce526e07444b7f864371dc54e5dc15
11 Ne7b1d37fc7ac4474845e5e98af0b4ea0
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author N6f93e441fe45423f93d81083e622d024
15 schema:datePublished 1998-07-06
16 schema:datePublishedReg 1998-07-06
17 schema:description The effect of lentil lectin (LCA) on the binding of mouse monoclonal antibody (MoAb) against human alpha-fetoprotein (AFP) to LCA-nonreactive AFP-L1 and LCA-reactive AFP-L3 was studied on a panel of 30 MoAbs provided by the TD-2 Workshop of ISOBM for epitope mapping. LCA inhibited the binding of MoAbs 93 and 98 to AFP-L3 but not to AFP-L1, indicating that there was a competition between the MoAbs and LCA for the AFP sugar chain. With MoAbs 100, 109, 118, and 120, LCA rather increased the binding to AFP-L3 over that to AFP-L1. These modulating effects of LCA on the MoAb binding to AFP-L3 were abolished by periodate treatment of the AFP preparations without affecting the binding of MoAb to AFP. Concanavalin A had similar inhibiting and enhancing effects on MoAb binding, but equally to AFP-L1 and AFP-L3, both of which are fully reactive with concanavalin A. The results suggested that MoAbs 93 and 98 recognized epitopes closely related to sugar chain, and their binding to AFP-L3 was inhibited by the bound LCA due to steric hindrance. The enhanced binding of some MoAbs to AFP-L3 over AFP-L1 with LCA, or both glycoforms of AFP with concanavalin A, may be explained by postulating an allosteric mechanism mediated by the oligosaccharide-lectin interaction.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N478f8aadac3844c7bf77a67d3bff0506
22 Nbf2d61a6cadb4835af9c1274dea01355
23 sg:journal.1091981
24 schema:keywords A.
25 AFP preparations
26 AFP sugar chain
27 AFP-L1
28 AFP-L3
29 L1
30 L3
31 LCA
32 MoAb
33 allosteric mechanism
34 alpha-fetoprotein
35 antibodies
36 binding
37 binding of MoAbs
38 chain
39 competition
40 concanavalin A
41 concanavalin A.
42 effect
43 enhanced binding
44 epitope mapping
45 epitopes
46 glycoforms
47 hindrance
48 human alpha-fetoprotein
49 inhibiting
50 interaction
51 lectin
52 lentil lectin
53 mapping
54 mechanism
55 modulating effect
56 modulation
57 monoclonal antibodies
58 mouse monoclonal antibody
59 panel
60 periodate treatment
61 preparation
62 results
63 steric hindrance
64 sugar chains
65 treatment
66 workshop
67 schema:name Lectin-Dependent Modulation of Interaction between Human Alpha-Fetoprotein and Its Monoclonal Antibodies
68 schema:pagination 318-328
69 schema:productId N33637a2eb43847229e1f9acc92f5114d
70 N7b646a172cf443aabe48f5485df40a56
71 Ne0c35605e5474caeb75e4535991a930d
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031800140
73 https://doi.org/10.1159/000030024
74 schema:sdDatePublished 2022-05-20T07:19
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nd4853ad67590486e8da41abcaebf1f5d
77 schema:url https://doi.org/10.1159/000030024
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0a69ae88194f41738e6c6c93d0d0d677 rdf:first sg:person.01010774023.01
82 rdf:rest N48b9be37e94c4acdb4d2954996ba7a99
83 N1d89e9402a634e14817a6e4b6d78bafa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Antibodies, Monoclonal
85 rdf:type schema:DefinedTerm
86 N1e3175061f4c40e8a6d33c0db7e0373e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Lectins
88 rdf:type schema:DefinedTerm
89 N20d7ea14366a426b8c4fc4b373c08118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Epitope Mapping
91 rdf:type schema:DefinedTerm
92 N2a6cdf9255d04ae190a8792e48b45685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Animals
94 rdf:type schema:DefinedTerm
95 N33637a2eb43847229e1f9acc92f5114d schema:name pubmed_id
96 schema:value 9679744
97 rdf:type schema:PropertyValue
98 N3f95d109ff1245be9de5c23ef275a056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name alpha-Fetoproteins
100 rdf:type schema:DefinedTerm
101 N4256a80dae2f4b87b819dc2546f28706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Plant Lectins
103 rdf:type schema:DefinedTerm
104 N478f8aadac3844c7bf77a67d3bff0506 schema:issueNumber 4
105 rdf:type schema:PublicationIssue
106 N48b9be37e94c4acdb4d2954996ba7a99 rdf:first sg:person.01057365017.14
107 rdf:rest rdf:nil
108 N6a80a7847a5041d786b0d501ad261211 rdf:first sg:person.01200436470.76
109 rdf:rest N0a69ae88194f41738e6c6c93d0d0d677
110 N6f93e441fe45423f93d81083e622d024 rdf:first sg:person.01235025162.49
111 rdf:rest N6a80a7847a5041d786b0d501ad261211
112 N72b533bb846d41c298880e242390d5ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 N7b646a172cf443aabe48f5485df40a56 schema:name dimensions_id
116 schema:value pub.1031800140
117 rdf:type schema:PropertyValue
118 N87bf007d75f34e4ebe1d0749bd130e2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Glycoproteins
120 rdf:type schema:DefinedTerm
121 Nbf2d61a6cadb4835af9c1274dea01355 schema:volumeNumber 19
122 rdf:type schema:PublicationVolume
123 Nbf587d400bd84035a986ae67d85063b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Concanavalin A
125 rdf:type schema:DefinedTerm
126 Nc3ce526e07444b7f864371dc54e5dc15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Protein Conformation
128 rdf:type schema:DefinedTerm
129 Nd4853ad67590486e8da41abcaebf1f5d schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Ne0c35605e5474caeb75e4535991a930d schema:name doi
132 schema:value 10.1159/000030024
133 rdf:type schema:PropertyValue
134 Ne7b1d37fc7ac4474845e5e98af0b4ea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice
136 rdf:type schema:DefinedTerm
137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
138 schema:name Medical and Health Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
141 schema:name Immunology
142 rdf:type schema:DefinedTerm
143 sg:journal.1091981 schema:issn 1010-4283
144 1423-0380
145 schema:name Tumor Biology
146 schema:publisher Springer Nature
147 rdf:type schema:Periodical
148 sg:person.01010774023.01 schema:affiliation grid-institutes:grid.261356.5
149 schema:familyName Satomura
150 schema:givenName Shinji
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010774023.01
152 rdf:type schema:Person
153 sg:person.01057365017.14 schema:affiliation grid-institutes:grid.261356.5
154 schema:familyName Taga
155 schema:givenName Hiroko
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057365017.14
157 rdf:type schema:Person
158 sg:person.01200436470.76 schema:affiliation grid-institutes:grid.261356.5
159 schema:familyName Kamakura
160 schema:givenName Kozue
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200436470.76
162 rdf:type schema:Person
163 sg:person.01235025162.49 schema:affiliation grid-institutes:grid.261356.5
164 schema:familyName Taketa
165 schema:givenName Kazuhisa
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235025162.49
167 rdf:type schema:Person
168 grid-institutes:grid.261356.5 schema:alternateName Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan
169 schema:name Department of Public Health, Okayama University Medical School, Okayama, Osaka Research Laboratories, Wako Pure Chemical Industries, Amagasaki, Tumor Laboratory, Kokubunji, Tokyo, Japan
170 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...