Transient Pseudohypoaldosteronism due to Urinary Tract Infection in Infancy: A Report of 4 Cases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009

AUTHORS

Radha Nandagopal, Priya Vaidyanathan, Paul Kaplowitz

ABSTRACT

Hyponatremia with hyperkalemia in infancy is an uncommon but life-threatening occurrence. In the first weeks of life, this scenario is often associated with aldosterone deficiency due to salt-wasting congenital adrenal hyperplasia. However, alternative diagnoses involving inadequate mineralocorticoid secretion or action must be considered, particularly for infants one month of age or older. We report four infants who presented with profound hyponatremia accompanied by urinary tract infection, ultimately leading to the diagnosis of transient pseudohypoaldosteronism. Our cases provide support for the idea that the renal tubular resistance to aldosterone is due to urinary tract infection itself rather than to underlying urinary tract anomalies typically found in these infants. Awareness of this condition is important so that serum aldosterone, urine sodium, and urine cultures may be obtained immediately in any infant presenting with hyponatremia and hyperkalemia in whom a diagnosis of congenital adrenal hyperplasia was not found. Adequate replacement with intravenous saline and antibiotic therapy is sufficient to correct sodium levels over 24-48 hours. More... »

PAGES

195728

Identifiers

URI

http://scigraph.springernature.com/pub.10.1155/2009/195728

DOI

http://dx.doi.org/10.1155/2009/195728

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052739150

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19946403


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