Time delay as a key to apoptosis induction in the p53 network View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-09

AUTHORS

G. Tiana, M.H. Jensen, K. Sneppen

ABSTRACT

A feedback mechanism that involves the proteins p53 and mdm2, induces cell death as a controlled response to severe DNA damage. A minimal model for this mechanism demonstrates that the response may be dynamic and connected with the time needed to translate the mdm2 protein. The response takes place if the dissociation constant k between p53 and mdm2 varies from its normal value. Although it is widely believed that it is an increase in k that triggers the response, we show that the experimental behaviour is better described by a decrease in the dissociation constant. The response is quite robust upon changes in the parameters of the system, as required by any control mechanism, except for few weak points, which could be connected with the onset of cancer. More... »

PAGES

135-140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1140/epjb/e2002-00271-1

DOI

http://dx.doi.org/10.1140/epjb/e2002-00271-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048078785


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