Influence of iron-molybdenum nanocluster polyoxometalates on the apoptosis of blood leukocytes and the level of heat-shock proteins in the cells ... View Full Text


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Article Info

DATE

2016-09

AUTHORS

I. G. Danilova, I. F. Gette, S. Yu. Medvedeva, A. V. Belousova, M. O. Tonkushina, A. A. Ostroushko

ABSTRACT

We have studied the influence of iron-molybdenum nanocluster polyoxometalates on the organism of animals (rats) in order to determine the correlation between the exposure and changes at the cellular level in the blood and immune system. Single and repeated administrations of polyoxometalates lead to an increase in the amount of cells containing heat-shock proteins (HSPs) HSP60 and HSP70 not only in the spleen but also in the thymus, despite the blood–thymus barrier. The enhancement of both early and late apoptosis in leukocytes after the administration of 30 doses of polyoxometalates may result from the disruption of homeostasis in immunopoietic organs. No changes in the blood parameters indicative of inflammatory process or anemia are observed at any exposure. The increased level of HSPs in the cells of thymus and spleen and the absence of changes indicative of inflammation in the blood leucocytes, apparently, support the viability of cells in studied organs, since no morphological disruptions are found in the thymus and the spleen. More... »

PAGES

653-662

References to SciGraph publications

  • 2013-09. Study of acute and subacute action of iron-molybdenum nanocluster polyoxometalates in NANOTECHNOLOGIES IN RUSSIA
  • 2014-09. Studies on the possibility of introducing iron-molybdenum buckyballs into an organism by electrophoresis in NANOTECHNOLOGIES IN RUSSIA
  • 2003. Spatial analysis of cell death and Hsp70 induction in brain, thymus, and bone marrow of the hyperthermic rat in CELL STRESS AND CHAPERONES
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  • 1972-08. Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics in BRITISH JOURNAL OF CANCER
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  • 1996-05. Role of Translocases in the Generation of Phosphatidylserine Asymmetry in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2002. The effect of hyperthermia on the induction of cell death in brain, testis, and thymus of the adult and developing rat. in CELL STRESS AND CHAPERONES
  • 2015-09. Changing the content of histone proteins and heat-shock proteins in the blood and liver of rats after the single and repeated administration of nanocluster iron-molybdenum polyoxometalates in NANOTECHNOLOGIES IN RUSSIA
  • Journal

    TITLE

    Nanotechnologies in Russia

    ISSUE

    9-10

    VOLUME

    11

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s1995078016050049

    DOI

    http://dx.doi.org/10.1134/s1995078016050049

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001713745


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