Effect of DNA methylation on the interaction with tetrahydrocortisol–apolipoprotein A-I complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

P. A. Kuznetsov, B. N. Zaitsev, O. I. Gimautdinova, E. N. Demchenko, L. E. Panin

ABSTRACT

The effect of GCNGC site methylation on the DNA binding to tetrahydrocortisol–apolipoprotein A-I complex was shown by atomic force microscopy and enzymatic analysis. Methylation of GCNGC sites alters the mechanism of interaction of tetrahydrocortisol–apolipoprotein A-I complex with DNA and leads to the aggregation of the DNA-protein complexes. It was assumed that the involvement of complexes of steroid hormones with apolipoprotein A-I in the process of chromatin restructuring is associated with the processes of DNA methylation/demethylation. More... »

PAGES

364-370

References to SciGraph publications

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URI

http://scigraph.springernature.com/pub.10.1134/s1995078016030101

DOI

http://dx.doi.org/10.1134/s1995078016030101

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049676392


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