Effect of silver nanoparticles encapsulated in a polymer matrix on the structure of nervous tissue and expression of caspase-3 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07

AUTHORS

E. A. Titov, M. A. Novikov, L. M. Sosedova

ABSTRACT

Results of histological and immunohistochemical studies of the nervous tissue of mongrel albino rats exposed to the influence of a nanobiocomposite containing silver nanoparticles and a natural biopolymer such as arabinogalactan for 9 days are under discussion. It is proved that both under acute exposure and in the survival period, the use of the examined substance leads to structural and functional changes in nervous tissue such as an increase in the number of hyperchromic cells, a creduction of the total number of cells per area unit, and the development of perivascular edema. The triggering of apoptosis of neurons of the brain manifested by a statistically significant increase in the number of cells which express caspase-3 pro-apoptotic protein is found. It is determined that silver nanoparticles encapsulated in a natural arabinogalactan polymer matrix penetrate the blood–brain barrier, thus causing long-term morphological and functional disturbances of the brain tissue in rats. More... »

PAGES

640-644

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1995078015040205

DOI

http://dx.doi.org/10.1134/s1995078015040205

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052072136


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