Acute inhalation toxicity of manganese oxide nanoparticles View Full Text


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Article Info

DATE

2015-05

AUTHORS

N. V. Zaitseva, M. A. Zemlyanova, V. N. Zvezdin, T. I. Akafieva, E. V. Saenko

ABSTRACT

Manganese oxides have been synthesized by the interaction of Mn2+ and Mn in the presence of nanoreactors: cetyltrimethylammonium bromide micelles that were not present in the final product composition. The synthesized substance is investigated using scanning electron microscopy, X-ray diffraction analysis, dynamic light scattering, the Brunauer-Emmett-Teller method, and the method of Barrett-Joyner-Halenda. It is determined that the substance under examination is a filamentous nanometer-scale material with a cross-section size up to 100 nm. The acute inhalation toxicity study is performed according to the interstate standard using the method of acute-toxicity class determination (ATC method) (OECD, Test no. 436:2008, IDT). The ATC method allows us to see that synthesized nanosized manganese oxide has an acute toxicity property when inhaled as an aerosol. Upon 4-h exposure to Wistar rats weighing 190 ± 10g, CL50 is 0.12 mg/L. The clinical picture of acute intoxication is characterized by irritation, neurotoxic effects, and respiratory depression. According to CL50 (>0.05–0.5), mg/L criterion, synthesized nanosized manganese oxide belongs to hazard class 2 in accordance with Globally Harmonized System of Classification and Labelling of Chemicals (GHS). More... »

PAGES

468-474

References to SciGraph publications

  • 2009-11. Neurotoxicity of manganese oxide nanomaterials in JOURNAL OF NANOPARTICLE RESEARCH
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    http://scigraph.springernature.com/pub.10.1134/s1995078015030180

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    http://dx.doi.org/10.1134/s1995078015030180

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