The production of nanoparticles based on sulfated polysaccharides and a study of their anticoagulant activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04

AUTHORS

A. V. Il’ina, A. N. Levov, N. M. Mestechkina, N. N. Drozd, V. N. Orlov, V. A. Makarov, V. D. Shcherbukhin, V. P. Varlamov, K. G. Skryabin

ABSTRACT

Experimental conditions of the formation of nanostructures from sulphated polysaccharide derivatives were selected. Nanoparticles based on galactomannan sulfates, alginic acid, a sulfated derivative of N-carboxymethylchitosan, and structures that simultaneously included galactomannan and chitosan sulfates were obtained for the first time. The formation conditions depended on the nature of the polysaccharides. The size and ζ-potential of the obtained nanostructures were determined. Their anticoagulant activity was studied in two tests: aIIa and aXa. It was shown that the activity of sulfated galactomannans and alginic acid in nanostructures increases when compared to the activity of these polysaccharides in solution. More... »

PAGES

244-252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1995078009030124

DOI

http://dx.doi.org/10.1134/s1995078009030124

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009721039


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