Recombinant intracellular Rhodospirillum rubrum L-asparaginase with low L-glutaminase activity and antiproliferative effect View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

M. V. Pokrovskaya, V. S. Pokrovskiy, S. S. Aleksandrova, N. Yu. Anisimova, R. M. Andrianov, E. M. Treschalina, G. V. Ponomarev, N. N. Sokolov

ABSTRACT

The recombinant producer strain expressing Rhodospirillum rubrum L-asparaginase (RrA) has been obtained and a purification procedure of RrA has been developed. The purified enzyme, RrA, has the following biochemical and catalytic characteristics: Km for L-Asn of 0.22 mM, pH optimum at 9.2; temperature optimum at 54°C, pI = 5.1. RrA exhibited a significant cytotoxic effect towards the following cell lines: K562 (IC50 = 1.80 U/mL), DU145 (IC50 = 9.19 U/mL), and MDA-MB-231 (IC50 = 34.62 U/mL). Comparative analysis employing E. coli L-asparaginase II type (EcA) and Erwinia carotovora L-asparaginase (EwA) has shown that the enzyme cytotoxicity towards these cell lines decreased in the following order: EcA > RrA > EwA. Daily administration of RrA (4000 U/kg) to L5178y bearing mice for 10 days (total dose of 40000 U/kg) showed T/C = 172. Data obtained suggest that RrA may be referred to intracellular L-asparaginases with low L-glutaminase activity and marked antiproliferative effect. More... »

PAGES

123-131

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1990750812020096

DOI

http://dx.doi.org/10.1134/s1990750812020096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019082411


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418846.7", 
          "name": [
            "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pokrovskaya", 
        "givenName": "M. V.", 
        "id": "sg:person.0765515374.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765515374.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.466904.9", 
          "name": [
            "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia", 
            "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pokrovskiy", 
        "givenName": "V. S.", 
        "id": "sg:person.016136567553.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016136567553.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418846.7", 
          "name": [
            "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aleksandrova", 
        "givenName": "S. S.", 
        "id": "sg:person.0705750123.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705750123.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.466904.9", 
          "name": [
            "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anisimova", 
        "givenName": "N. Yu.", 
        "id": "sg:person.0674644427.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674644427.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospekt 33, bld. 2, 119071, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.425156.1", 
          "name": [
            "Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospekt 33, bld. 2, 119071, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrianov", 
        "givenName": "R. M.", 
        "id": "sg:person.01237612646.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237612646.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.466904.9", 
          "name": [
            "Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Treschalina", 
        "givenName": "E. M.", 
        "id": "sg:person.013274027245.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013274027245.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418846.7", 
          "name": [
            "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ponomarev", 
        "givenName": "G. V.", 
        "id": "sg:person.01070465134.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070465134.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418846.7", 
          "name": [
            "Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sokolov", 
        "givenName": "N. N.", 
        "id": "sg:person.013157275324.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013157275324.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-642-99984-0_40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051392037", 
          "https://doi.org/10.1007/978-3-642-99984-0_40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02983387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027266671", 
          "https://doi.org/10.1007/bf02983387"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-04", 
    "datePublishedReg": "2012-04-01", 
    "description": "The recombinant producer strain expressing Rhodospirillum rubrum L-asparaginase (RrA) has been obtained and a purification procedure of RrA has been developed. The purified enzyme, RrA, has the following biochemical and catalytic characteristics: Km for L-Asn of 0.22 mM, pH optimum at 9.2; temperature optimum at 54\u00b0C, pI = 5.1. RrA exhibited a significant cytotoxic effect towards the following cell lines: K562 (IC50 = 1.80 U/mL), DU145 (IC50 = 9.19 U/mL), and MDA-MB-231 (IC50 = 34.62 U/mL). Comparative analysis employing E. coli L-asparaginase II type (EcA) and Erwinia carotovora L-asparaginase (EwA) has shown that the enzyme cytotoxicity towards these cell lines decreased in the following order: EcA > RrA > EwA. Daily administration of RrA (4000 U/kg) to L5178y bearing mice for 10 days (total dose of 40000 U/kg) showed T/C = 172. Data obtained suggest that RrA may be referred to intracellular L-asparaginases with low L-glutaminase activity and marked antiproliferative effect.", 
    "genre": "article", 
    "id": "sg:pub.10.1134/s1990750812020096", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1039732", 
        "issn": [
          "1990-7508", 
          "1990-7516"
        ], 
        "name": "Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry", 
        "publisher": "Pleiades Publishing", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "antiproliferative effects", 
      "cell lines", 
      "MDA-MB-231", 
      "Rhodospirillum rubrum L", 
      "daily administration", 
      "bearing mice", 
      "significant cytotoxic effect", 
      "glutaminase activity", 
      "cytotoxic effects", 
      "asparaginase", 
      "Erwinia carotovora L", 
      "RRA", 
      "coli L", 
      "administration", 
      "mice", 
      "DU145", 
      "effect", 
      "activity", 
      "K562", 
      "days", 
      "cytotoxicity", 
      "lines", 
      "mM", 
      "procedure", 
      "enzyme", 
      "strains", 
      "producer strain", 
      "data", 
      "PI", 
      "types", 
      "Km", 
      "analysis", 
      "ECA", 
      "characteristics", 
      "comparative analysis", 
      "Asn", 
      "purification procedure", 
      "order", 
      "catalytic characteristics", 
      "optimum", 
      "temperature", 
      "recombinant producer strain", 
      "rubrum L", 
      "asparaginase II type", 
      "II type", 
      "carotovora L", 
      "enzyme cytotoxicity", 
      "EwA.", 
      "L5178y bearing mice", 
      "Recombinant intracellular Rhodospirillum rubrum L", 
      "intracellular Rhodospirillum rubrum L"
    ], 
    "name": "Recombinant intracellular Rhodospirillum rubrum L-asparaginase with low L-glutaminase activity and antiproliferative effect", 
    "pagination": "123-131", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019082411"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1134/s1990750812020096"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1134/s1990750812020096", 
      "https://app.dimensions.ai/details/publication/pub.1019082411"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_579.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1134/s1990750812020096"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s1990750812020096'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s1990750812020096'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s1990750812020096'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s1990750812020096'


 

This table displays all metadata directly associated to this object as RDF triples.

173 TRIPLES      22 PREDICATES      79 URIs      69 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1134/s1990750812020096 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N28c99e87a8e94ec3b57757745c2fa35d
4 schema:citation sg:pub.10.1007/978-3-642-99984-0_40
5 sg:pub.10.1007/bf02983387
6 schema:datePublished 2012-04
7 schema:datePublishedReg 2012-04-01
8 schema:description The recombinant producer strain expressing Rhodospirillum rubrum L-asparaginase (RrA) has been obtained and a purification procedure of RrA has been developed. The purified enzyme, RrA, has the following biochemical and catalytic characteristics: Km for L-Asn of 0.22 mM, pH optimum at 9.2; temperature optimum at 54°C, pI = 5.1. RrA exhibited a significant cytotoxic effect towards the following cell lines: K562 (IC50 = 1.80 U/mL), DU145 (IC50 = 9.19 U/mL), and MDA-MB-231 (IC50 = 34.62 U/mL). Comparative analysis employing E. coli L-asparaginase II type (EcA) and Erwinia carotovora L-asparaginase (EwA) has shown that the enzyme cytotoxicity towards these cell lines decreased in the following order: EcA > RrA > EwA. Daily administration of RrA (4000 U/kg) to L5178y bearing mice for 10 days (total dose of 40000 U/kg) showed T/C = 172. Data obtained suggest that RrA may be referred to intracellular L-asparaginases with low L-glutaminase activity and marked antiproliferative effect.
9 schema:genre article
10 schema:inLanguage en
11 schema:isAccessibleForFree false
12 schema:isPartOf N0fc0b40195a947ea967f6d9307268d9b
13 N1dde57b3ffe24378a1c0726b36eab094
14 sg:journal.1039732
15 schema:keywords Asn
16 DU145
17 ECA
18 Erwinia carotovora L
19 EwA.
20 II type
21 K562
22 Km
23 L5178y bearing mice
24 MDA-MB-231
25 PI
26 RRA
27 Recombinant intracellular Rhodospirillum rubrum L
28 Rhodospirillum rubrum L
29 activity
30 administration
31 analysis
32 antiproliferative effects
33 asparaginase
34 asparaginase II type
35 bearing mice
36 carotovora L
37 catalytic characteristics
38 cell lines
39 characteristics
40 coli L
41 comparative analysis
42 cytotoxic effects
43 cytotoxicity
44 daily administration
45 data
46 days
47 effect
48 enzyme
49 enzyme cytotoxicity
50 glutaminase activity
51 intracellular Rhodospirillum rubrum L
52 lines
53 mM
54 mice
55 optimum
56 order
57 procedure
58 producer strain
59 purification procedure
60 recombinant producer strain
61 rubrum L
62 significant cytotoxic effect
63 strains
64 temperature
65 types
66 schema:name Recombinant intracellular Rhodospirillum rubrum L-asparaginase with low L-glutaminase activity and antiproliferative effect
67 schema:pagination 123-131
68 schema:productId N67d240836eb34a1cbfb17f8044975ca6
69 N7fa8a01e99f748f084cbd67be47dfeb8
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019082411
71 https://doi.org/10.1134/s1990750812020096
72 schema:sdDatePublished 2021-11-01T18:19
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N0d52cb208b634a359adc1c71f25155d6
75 schema:url https://doi.org/10.1134/s1990750812020096
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0d52cb208b634a359adc1c71f25155d6 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N0fc0b40195a947ea967f6d9307268d9b schema:issueNumber 2
82 rdf:type schema:PublicationIssue
83 N12f976ef629843e795af9b478a62bcab rdf:first sg:person.0705750123.55
84 rdf:rest Ne2452393e5da4411bb67907ea7e12724
85 N1dde57b3ffe24378a1c0726b36eab094 schema:volumeNumber 6
86 rdf:type schema:PublicationVolume
87 N28c99e87a8e94ec3b57757745c2fa35d rdf:first sg:person.0765515374.50
88 rdf:rest Nde3fd609353943d18939f9c319917d20
89 N67d240836eb34a1cbfb17f8044975ca6 schema:name doi
90 schema:value 10.1134/s1990750812020096
91 rdf:type schema:PropertyValue
92 N7fa8a01e99f748f084cbd67be47dfeb8 schema:name dimensions_id
93 schema:value pub.1019082411
94 rdf:type schema:PropertyValue
95 N876cc9303250415a9bd32a029c76262a rdf:first sg:person.013157275324.77
96 rdf:rest rdf:nil
97 Nbe939c285aee4243bf13df66ce53df42 rdf:first sg:person.013274027245.09
98 rdf:rest Nf29a72d078a0478db2837e60dac4199f
99 Nde3fd609353943d18939f9c319917d20 rdf:first sg:person.016136567553.67
100 rdf:rest N12f976ef629843e795af9b478a62bcab
101 Ne2452393e5da4411bb67907ea7e12724 rdf:first sg:person.0674644427.38
102 rdf:rest Nff1f9afc1c894ae58759d9ebc3043133
103 Nf29a72d078a0478db2837e60dac4199f rdf:first sg:person.01070465134.19
104 rdf:rest N876cc9303250415a9bd32a029c76262a
105 Nff1f9afc1c894ae58759d9ebc3043133 rdf:first sg:person.01237612646.09
106 rdf:rest Nbe939c285aee4243bf13df66ce53df42
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
111 schema:name Clinical Sciences
112 rdf:type schema:DefinedTerm
113 sg:journal.1039732 schema:issn 1990-7508
114 1990-7516
115 schema:name Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry
116 schema:publisher Pleiades Publishing
117 rdf:type schema:Periodical
118 sg:person.01070465134.19 schema:affiliation grid-institutes:grid.418846.7
119 schema:familyName Ponomarev
120 schema:givenName G. V.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070465134.19
122 rdf:type schema:Person
123 sg:person.01237612646.09 schema:affiliation grid-institutes:grid.425156.1
124 schema:familyName Andrianov
125 schema:givenName R. M.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237612646.09
127 rdf:type schema:Person
128 sg:person.013157275324.77 schema:affiliation grid-institutes:grid.418846.7
129 schema:familyName Sokolov
130 schema:givenName N. N.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013157275324.77
132 rdf:type schema:Person
133 sg:person.013274027245.09 schema:affiliation grid-institutes:grid.466904.9
134 schema:familyName Treschalina
135 schema:givenName E. M.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013274027245.09
137 rdf:type schema:Person
138 sg:person.016136567553.67 schema:affiliation grid-institutes:grid.466904.9
139 schema:familyName Pokrovskiy
140 schema:givenName V. S.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016136567553.67
142 rdf:type schema:Person
143 sg:person.0674644427.38 schema:affiliation grid-institutes:grid.466904.9
144 schema:familyName Anisimova
145 schema:givenName N. Yu.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674644427.38
147 rdf:type schema:Person
148 sg:person.0705750123.55 schema:affiliation grid-institutes:grid.418846.7
149 schema:familyName Aleksandrova
150 schema:givenName S. S.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705750123.55
152 rdf:type schema:Person
153 sg:person.0765515374.50 schema:affiliation grid-institutes:grid.418846.7
154 schema:familyName Pokrovskaya
155 schema:givenName M. V.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765515374.50
157 rdf:type schema:Person
158 sg:pub.10.1007/978-3-642-99984-0_40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051392037
159 https://doi.org/10.1007/978-3-642-99984-0_40
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/bf02983387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027266671
162 https://doi.org/10.1007/bf02983387
163 rdf:type schema:CreativeWork
164 grid-institutes:grid.418846.7 schema:alternateName Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia
165 schema:name Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia
166 rdf:type schema:Organization
167 grid-institutes:grid.425156.1 schema:alternateName Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospekt 33, bld. 2, 119071, Moscow, Russia
168 schema:name Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospekt 33, bld. 2, 119071, Moscow, Russia
169 rdf:type schema:Organization
170 grid-institutes:grid.466904.9 schema:alternateName Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia
171 schema:name Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Kashirskoye shosse 24, 115478, Moscow, Russia
172 Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia
173 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...