The analysis of interaction of lipoproteins and steroid hormones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

L. M. Polyakov, D. V. Sumenkova, R. A. Knyazev, L. E. Panin

ABSTRACT

Using the methods of gel-filtration and fluorescence quenching, it has been demonstrated that plasma lipoproteins bind steroid hormones and can therefore play a role in their active transport in the body. High density lipoproteins demonstrate the highest affinity for steroids. The lipoprotein-steroid complex formation involves the protein components of lipoproteins with the apolipoprotein A-I as one the protein components responsible for binding of steroid hormones. The calculated constants of the complex formation between lipoproteins and steroid hormones suggest specificity of this binding. The data obtained suggest a real possibility of penetration of steroid hormones into cells by a receptor-mediated endocytosis using the lipoprotein complexes as a vehicle. More... »

PAGES

362-365

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1990750810040062

DOI

http://dx.doi.org/10.1134/s1990750810040062

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021691331


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