Effects of extracellular YB-1 protein on cultured cells of human breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01

AUTHORS

N. I. Moiseeva, T. P. Stromskaya, E. Yu. Rybalkina, A. V. Vaiman, M. A. Malyshkina, E. R. Kim, I. A. Eliseeva, I. V. Kulakovskiy, L. P. Ovchinnikov, A. A. Stavrovskaya

ABSTRACT

Multifunctional protein YB-1, which takes a part in many DNA/RNA-associated events in cells (transcription, mRNA translation, splicing) is a promising prognostic and predictive marker for various human tumors. Recently it was discovered that protein YB-1 secreted by cells functions as an extracellular mitogen. These results were obtained on kidney mesangial cells and monocytes. Here we studied the effects of extracellular YB-1 on the cell number, migration and gene expression in the populations of three lines of human malignant breast cells (MCF-7, HBL-100, BT-474). We used recombinant full-length protein YB-1, which retained all the functional sites necessary for its various activities, including binding to the receptor Notch-3 (rYB-1). Extracellular rYB-1 increased the number of cells 2- to 3-fold in the tested lines. The wound was made in cell monolayers of HBL-100, MCF-7 and MCF-7/ras. Protein rYB-1 increased the rate of wound healing in MCF-7/ras. Sensitivity to chemotherapeutic agents did not change in the presence of rYB-1 in any of the cell lines studied. We have used expression microarrays to study the effects of rYB-1 on the profile of gene expression in MCF-7 cells and in MCF-7 cells transfected with YB-1-GFP construct. In MCF-7 cells extracellular rYB-1 mainly down-regulated different genes, while in the cells transfected with cDNA of YB-1-GFP the activity of different genes was up-regulated. Our results show that extracellular YB-1 protein and intracellular YB-1 produce diverse changes in the cells of mammary tumors. It is possible that extracellular YB-1 is involved in the regulation of cell proliferation and migration in the metastatic niche. More... »

PAGES

21-28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1990747812050133

DOI

http://dx.doi.org/10.1134/s1990747812050133

DIMENSIONS

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