Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

A. R. Gizatullin, N. P. Akentieva, N. A. Sanina, N. Yu. Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, N. Zhelev, S. M. Aldoshin

ABSTRACT

The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases. More... »

PAGES

337-340

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1607672918060133

DOI

http://dx.doi.org/10.1134/s1607672918060133

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111097798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30607734


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