The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

O. A. Bezborodova, I. V. Alekseenko, E. R. Nemtsova, A. A. Pankratov, O. B. Filyukova, R. I. Yakubovskaya, M. B. Kostina, V. K. Potapov, E. D. Sverdlov

ABSTRACT

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model. More... »

PAGES

326-328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1607672918060091

DOI

http://dx.doi.org/10.1134/s1607672918060091

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111097795

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30607731


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