The inhibitory effect of dinitrosyl iron complexes (NO donors) on myeloperoxidase activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

N. P. Akentieva, N. A. Sanina, A. R. Gizatullin, N. Y. Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prikhodchenko, S. M. Aldoshin

ABSTRACT

The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC50 = 2 × 10–4 M and IC50 = 5 × 10–7 M. More... »

PAGES

389-393

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1607672917060126

DOI

http://dx.doi.org/10.1134/s1607672917060126

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100156399

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29297116


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