Radiation Synthesis of Hydrogels with Silver Nanoparticles for Use as an Antimicrobial Burn Wound Dressing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-03-21

AUTHORS

Rita Singh, Antaryami Singh

ABSTRACT

Colonization of skin wounds with high levels of microorganisms impedes the process of healing. The present study reports the synthesis of silver nanoparticles in the network of hydrogel comprising polyvinyl pyrrolidone blended with carboxymethyl cellulose and their treatment by gamma radiation for hydrogel formation for use as skin dressing for burn wound management. The blend was supplemented with various amounts of silver nitrate and gamma irradiated at 40 kGy for formation of silver nanoparticles. The fluid absorption capacity of the obtained composite hydrogels ranged from 460 ± 50% at 1 h to 1700 ± 100% in 24 h. The zone of inhibition ranged from 6 to 9 mm for bacterial strain Staphylococcus aureus and Pseudomonas aeruginosa in the presence of hydrogel containing 0.01% silver nanoparticles. More than 3 log reduction of tested wounds pathogens was observed with hydrogels containing 0.01% silver nanoparticles indicating microbicidal efficacy. Viable counts were not detected for bacterial and fungal strains Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans following treatment to 0.01% silver nanoparticle hydrogels for 1 to 5 h. The results of fluid handling capacity and antimicrobial efficacy demonstrate that obtained hydrogels with incorporated silver nanoparticles can be effectively used for controlling microbial infection and enhancing burn wound healing. More... »

PAGES

188-197

References to SciGraph publications

  • 2013-05-25. Use of gamma-irradiated amniotic membrane for the healing of split skin graft donor site in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2007-03-30. The skin barrier as an innate immune element in SEMINARS IN IMMUNOPATHOLOGY
  • 2007. Materials Chemistry in NONE
  • 2004-02-17. Aging and Wound Healing in WORLD JOURNAL OF SURGERY
  • 2004-06. Radiation Processed Amniotic Membranes in the Treatment of Non-Healing Ulcers of Different Etiologies in CELL AND TISSUE BANKING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s1560090422020117

    DOI

    http://dx.doi.org/10.1134/s1560090422020117

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1146459031


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Macromolecular and Materials Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Materials Engineering", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Defence Laboratory, Defence Research and Development Organization, Jodhpur, India", 
                "Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rita Singh", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Defence Laboratory, Defence Research and Development Organization, Jodhpur, India", 
                "Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Antaryami Singh", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s13770-013-0004-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036446011", 
              "https://doi.org/10.1007/s13770-013-0004-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4020-6120-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002031391", 
              "https://doi.org/10.1007/978-1-4020-6120-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-007-0060-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027640334", 
              "https://doi.org/10.1007/s00281-007-0060-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-003-7397-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046545379", 
              "https://doi.org/10.1007/s00268-003-7397-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:catb.0000034077.05000.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005839366", 
              "https://doi.org/10.1023/b:catb.0000034077.05000.29"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-03-21", 
        "datePublishedReg": "2022-03-21", 
        "description": "Colonization of skin wounds with high levels of microorganisms impedes the process of healing. The present study reports the synthesis of silver nanoparticles in the network of hydrogel comprising polyvinyl pyrrolidone blended with carboxymethyl cellulose and their treatment by gamma radiation for hydrogel formation for use as skin dressing for burn wound management. The blend was supplemented with various amounts of silver nitrate and gamma irradiated at 40 kGy for formation of silver nanoparticles. The fluid absorption capacity of the obtained composite hydrogels ranged from 460 \u00b1 50% at 1 h to 1700 \u00b1 100% in 24\u00a0h. The zone of inhibition ranged from 6 to 9 mm for bacterial strain Staphylococcus aureus and Pseudomonas aeruginosa in the presence of hydrogel containing 0.01% silver nanoparticles. More than 3 log reduction of tested wounds pathogens was observed with hydrogels containing 0.01% silver nanoparticles indicating microbicidal efficacy. Viable counts were not detected for bacterial and fungal strains Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans following treatment to 0.01% silver nanoparticle hydrogels for 1 to 5 h. The results of fluid handling capacity and antimicrobial efficacy demonstrate that obtained hydrogels with incorporated silver nanoparticles can be effectively used for controlling microbial infection and enhancing burn wound healing.", 
        "genre": "article", 
        "id": "sg:pub.10.1134/s1560090422020117", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1400109", 
            "issn": [
              "0965-545X", 
              "1023-3091"
            ], 
            "name": "Polymer Science, Series B", 
            "publisher": "Pleiades Publishing", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "64"
          }
        ], 
        "keywords": [
          "silver nanoparticles", 
          "incorporated silver nanoparticles", 
          "composite hydrogels", 
          "fluid handling capacity", 
          "nanoparticle hydrogels", 
          "fluid absorption capacity", 
          "absorption capacity", 
          "handling capacity", 
          "hydrogels", 
          "hydrogel formation", 
          "polyvinyl pyrrolidone", 
          "presence of hydrogel", 
          "nanoparticles", 
          "carboxymethyl cellulose", 
          "Radiation synthesis", 
          "silver nitrate", 
          "log reduction", 
          "blends", 
          "pyrrolidone", 
          "capacity", 
          "microbicidal efficacy", 
          "cellulose", 
          "formation", 
          "antimicrobial efficacy", 
          "zone", 
          "gamma radiation", 
          "viable counts", 
          "process", 
          "nitrate", 
          "bacterial strains Staphylococcus aureus", 
          "radiation", 
          "use", 
          "reduction", 
          "amount", 
          "network", 
          "results", 
          "synthesis", 
          "strains Staphylococcus aureus", 
          "dressing", 
          "healing", 
          "zone of inhibition", 
          "burn wound management", 
          "present study", 
          "microorganisms", 
          "process of healing", 
          "burns", 
          "presence", 
          "wound management", 
          "study", 
          "skin wounds", 
          "wound healing", 
          "treatment", 
          "Staphylococcus aureus", 
          "high levels", 
          "levels", 
          "skin", 
          "Escherichia coli", 
          "management", 
          "Pseudomonas aeruginosa", 
          "wound pathogens", 
          "aureus", 
          "microbial infections", 
          "wounds", 
          "aeruginosa", 
          "coli", 
          "count", 
          "Candida albicans", 
          "gamma", 
          "efficacy", 
          "fungal", 
          "colonization", 
          "pathogens", 
          "albicans", 
          "inhibition", 
          "infection"
        ], 
        "name": "Radiation Synthesis of Hydrogels with Silver Nanoparticles for Use as an Antimicrobial Burn Wound Dressing", 
        "pagination": "188-197", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1146459031"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1134/s1560090422020117"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1134/s1560090422020117", 
          "https://app.dimensions.ai/details/publication/pub.1146459031"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_938.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1134/s1560090422020117"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s1560090422020117'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s1560090422020117'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s1560090422020117'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s1560090422020117'


     

    This table displays all metadata directly associated to this object as RDF triples.

    164 TRIPLES      21 PREDICATES      106 URIs      91 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1134/s1560090422020117 schema:about anzsrc-for:03
    2 anzsrc-for:0303
    3 anzsrc-for:09
    4 anzsrc-for:0912
    5 schema:author N49d3be2d8afc49248d74796ba6b884bb
    6 schema:citation sg:pub.10.1007/978-1-4020-6120-2
    7 sg:pub.10.1007/s00268-003-7397-6
    8 sg:pub.10.1007/s00281-007-0060-9
    9 sg:pub.10.1007/s13770-013-0004-5
    10 sg:pub.10.1023/b:catb.0000034077.05000.29
    11 schema:datePublished 2022-03-21
    12 schema:datePublishedReg 2022-03-21
    13 schema:description Colonization of skin wounds with high levels of microorganisms impedes the process of healing. The present study reports the synthesis of silver nanoparticles in the network of hydrogel comprising polyvinyl pyrrolidone blended with carboxymethyl cellulose and their treatment by gamma radiation for hydrogel formation for use as skin dressing for burn wound management. The blend was supplemented with various amounts of silver nitrate and gamma irradiated at 40 kGy for formation of silver nanoparticles. The fluid absorption capacity of the obtained composite hydrogels ranged from 460 ± 50% at 1 h to 1700 ± 100% in 24 h. The zone of inhibition ranged from 6 to 9 mm for bacterial strain Staphylococcus aureus and Pseudomonas aeruginosa in the presence of hydrogel containing 0.01% silver nanoparticles. More than 3 log reduction of tested wounds pathogens was observed with hydrogels containing 0.01% silver nanoparticles indicating microbicidal efficacy. Viable counts were not detected for bacterial and fungal strains Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans following treatment to 0.01% silver nanoparticle hydrogels for 1 to 5 h. The results of fluid handling capacity and antimicrobial efficacy demonstrate that obtained hydrogels with incorporated silver nanoparticles can be effectively used for controlling microbial infection and enhancing burn wound healing.
    14 schema:genre article
    15 schema:isAccessibleForFree false
    16 schema:isPartOf N1ac52f2e1ec444018f5779a9b95fd448
    17 N4fa806f5b0de450893276138b0bbac43
    18 sg:journal.1400109
    19 schema:keywords Candida albicans
    20 Escherichia coli
    21 Pseudomonas aeruginosa
    22 Radiation synthesis
    23 Staphylococcus aureus
    24 absorption capacity
    25 aeruginosa
    26 albicans
    27 amount
    28 antimicrobial efficacy
    29 aureus
    30 bacterial strains Staphylococcus aureus
    31 blends
    32 burn wound management
    33 burns
    34 capacity
    35 carboxymethyl cellulose
    36 cellulose
    37 coli
    38 colonization
    39 composite hydrogels
    40 count
    41 dressing
    42 efficacy
    43 fluid absorption capacity
    44 fluid handling capacity
    45 formation
    46 fungal
    47 gamma
    48 gamma radiation
    49 handling capacity
    50 healing
    51 high levels
    52 hydrogel formation
    53 hydrogels
    54 incorporated silver nanoparticles
    55 infection
    56 inhibition
    57 levels
    58 log reduction
    59 management
    60 microbial infections
    61 microbicidal efficacy
    62 microorganisms
    63 nanoparticle hydrogels
    64 nanoparticles
    65 network
    66 nitrate
    67 pathogens
    68 polyvinyl pyrrolidone
    69 presence
    70 presence of hydrogel
    71 present study
    72 process
    73 process of healing
    74 pyrrolidone
    75 radiation
    76 reduction
    77 results
    78 silver nanoparticles
    79 silver nitrate
    80 skin
    81 skin wounds
    82 strains Staphylococcus aureus
    83 study
    84 synthesis
    85 treatment
    86 use
    87 viable counts
    88 wound healing
    89 wound management
    90 wound pathogens
    91 wounds
    92 zone
    93 zone of inhibition
    94 schema:name Radiation Synthesis of Hydrogels with Silver Nanoparticles for Use as an Antimicrobial Burn Wound Dressing
    95 schema:pagination 188-197
    96 schema:productId N115210e984e14013a70c66eaa9819e8a
    97 Nf45fc83bb08b430ea007df135c0b306e
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1146459031
    99 https://doi.org/10.1134/s1560090422020117
    100 schema:sdDatePublished 2022-08-04T17:12
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N19d35616d84541cb8b343d8b1feeeab3
    103 schema:url https://doi.org/10.1134/s1560090422020117
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N115210e984e14013a70c66eaa9819e8a schema:name doi
    108 schema:value 10.1134/s1560090422020117
    109 rdf:type schema:PropertyValue
    110 N19d35616d84541cb8b343d8b1feeeab3 schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N1ac52f2e1ec444018f5779a9b95fd448 schema:volumeNumber 64
    113 rdf:type schema:PublicationVolume
    114 N49d3be2d8afc49248d74796ba6b884bb rdf:first N6afccdc160f64cb1aefc5bed75ad2e1b
    115 rdf:rest Nd15a4897b7ac464996e2d2f78eba600a
    116 N4fa806f5b0de450893276138b0bbac43 schema:issueNumber 2
    117 rdf:type schema:PublicationIssue
    118 N6afccdc160f64cb1aefc5bed75ad2e1b schema:affiliation grid-institutes:None
    119 schema:familyName Rita Singh
    120 rdf:type schema:Person
    121 N84c16c78bc5740849fb958420b43fb8f schema:affiliation grid-institutes:None
    122 schema:familyName Antaryami Singh
    123 rdf:type schema:Person
    124 Nd15a4897b7ac464996e2d2f78eba600a rdf:first N84c16c78bc5740849fb958420b43fb8f
    125 rdf:rest rdf:nil
    126 Nf45fc83bb08b430ea007df135c0b306e schema:name dimensions_id
    127 schema:value pub.1146459031
    128 rdf:type schema:PropertyValue
    129 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    130 schema:name Chemical Sciences
    131 rdf:type schema:DefinedTerm
    132 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
    133 schema:name Macromolecular and Materials Chemistry
    134 rdf:type schema:DefinedTerm
    135 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Engineering
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Materials Engineering
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1400109 schema:issn 0965-545X
    142 1023-3091
    143 schema:name Polymer Science, Series B
    144 schema:publisher Pleiades Publishing
    145 rdf:type schema:Periodical
    146 sg:pub.10.1007/978-1-4020-6120-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002031391
    147 https://doi.org/10.1007/978-1-4020-6120-2
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1007/s00268-003-7397-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046545379
    150 https://doi.org/10.1007/s00268-003-7397-6
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1007/s00281-007-0060-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027640334
    153 https://doi.org/10.1007/s00281-007-0060-9
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/s13770-013-0004-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036446011
    156 https://doi.org/10.1007/s13770-013-0004-5
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1023/b:catb.0000034077.05000.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005839366
    159 https://doi.org/10.1023/b:catb.0000034077.05000.29
    160 rdf:type schema:CreativeWork
    161 grid-institutes:None schema:alternateName Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India
    162 schema:name Defence Institute of Bio-Energy Research (DIBER) Field Station, DRDO, 262501, Pithoragarh, India
    163 Defence Laboratory, Defence Research and Development Organization, Jodhpur, India
    164 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...