Synthesis and Chemical Transformations of 7-Hydroxybicyclo[3.3.1]nonane-3-carbohydrazide View Full Text


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Article Info

DATE

2020-11

AUTHORS

N. S. Baleeva, V. B. Rybakov, E. A. Ivleva, V. A. Shiryaev, Yu. N. Klimochkin

ABSTRACT

The reaction of 4-oxahomoadamantan-5-one with hydrazine gave (3-exo,7-endo)-7-hydroxybicyclo[3.3.1]nonane-3-carbohydrazide. The latter was reacted with benzonitrile, formamide, and p-(trifluoromethyl)benzaldehyde to obtain a number of new bicyclo[3.3.1]nonane derivatives. The structural features of the new compounds were studied using 2D NMR spectroscopy and XRD analysis. The synthesized bicyclo[3.3.1]nonanes can be used in the directed synthesis of compounds of high molecular complexity for biological activity testing. More... »

PAGES

1942-1951

References to SciGraph publications

  • 2011-12. Reaction of dibromoadamantanes with glycols in the presence of sodium glycolate in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • 2010-12. Diels-alder reaction as a synthetic approach to bicyclo[3.3.1]nonane colchicine analogs in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • 2012-01. Synthesis and antiviral activity of new adamantane derivatives in PHARMACEUTICAL CHEMISTRY JOURNAL
  • 2001-07. New Fragmentation of 1,3-Dibromoadamantane in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • 2020-06. Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds in CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • 2015-07. Antiviral properties of cage compounds. New prospects in RUSSIAN CHEMICAL BULLETIN
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    http://scigraph.springernature.com/pub.10.1134/s1070428020110081

    DOI

    http://dx.doi.org/10.1134/s1070428020110081

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