Synthesis of Nonracemic Tetrazole GABA Analogs View Full Text


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Article Info

DATE

2018-11

AUTHORS

A. N. Reznikov, V. A. Ostrovskii, Yu. N. Klimochkin

ABSTRACT

Nonracemic 3-substituted 4-(1H-tetrazol-1-yl)butanoic acids, analogs of the neurotropic drugs phenibut, tolibut, and baclofen, were synthesized by a three-component reaction of the R-isomers of the corresponding amino acids, triethyl orthoformate, and sodium azide. The key stage of the synthesis is the asymmetric addition of diethyl malonate to nitroalkenes, catalyzed by a Ni(II) complex of (S,S)-N,N′-dibenzylcyclohexane-1,2-diamine. More... »

PAGES

1715-1721

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070428018110155

DOI

http://dx.doi.org/10.1134/s1070428018110155

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111953586


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