Synthesis of Potentially Bioactive 6-Bromobenzo[f]isoindolinium Bromides by Base-Catalyzed Intramolecular [4+2]-Cycloaddition View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

E. O. Chukhadzhian, H. R. Gevorgyan, L. V. Ayrapetyan, El. O. Chukhadzhian, K. G. Shahkhatuni, A. S. Mkrtchyan, G. A. Panosyan

ABSTRACT

Intramolecular cyclization of bromides of diethyl-, dipropyl-, and penthamethylenepropargyl[3-(4-bromophenyl)prop-2-ynyl]ammonium into 6-bromobenzo[f]isoindolinium bromides catalyzed with bases occurs with moderate self-heating. The morpholine analog even in more diluted solutions reacts with vigorous self-heating. Cyclization of dimethyl analog takes place only at heating at 80–85°C during 1 h.

PAGES

1156-1160

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070428018080067

DOI

http://dx.doi.org/10.1134/s1070428018080067

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107599595


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