Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

D. V. Seliverstova, V. V. Suslonov, V. V. Zarubaev, R. E. Trifonov

ABSTRACT

Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity. More... »

PAGES

633-638

References to SciGraph publications

  • 2012-04. Medicinal chemistry of tetrazoles in RUSSIAN CHEMICAL BULLETIN
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s107042801804019x

    DOI

    http://dx.doi.org/10.1134/s107042801804019x

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