Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1H-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

A. D. Zorina, A. S. Kaledina, I. A. Motsepuro, V. V. Anokhina, S. A. Marchenko, S. I. Selivanov, V. V. Zarubaev, R. E. Trifonov

ABSTRACT

A series of 3-(2-1Н-tetrazol-5-ylethoxy- and 2-1Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26).

PAGES

1710-1716

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070428017110185

DOI

http://dx.doi.org/10.1134/s1070428017110185

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099921438


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