Synthesis, Antimicrobial, and Antioxidant Studies of Some New Indolo[3,2-c]isoquinoline Derivatives View Full Text


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Article Info

DATE

2018-12

AUTHORS

Vaijinath A. Verma

ABSTRACT

As a part of systematic study, new series of 6-{[5-(5-substituted 2-phenyl-1H-indol-3-yl)- methyleneamino]-1,3,4-oxadiazol-2-yl}-8-substituted-6H-indolo[3,2-c]isoquinolin-5(11H)-ones and their derivatives are synthesized and evaluated for their biological activities. Compound 8a displays potent antimicrobial activity against bacteria E. coli, K. penumoniae, and S. aureus, and fungi A. niger, A. flavus, and A. fumigates. Compounds 7a and 8a demonstrate promising radical scavenging and chelating with ferrous ions (Fe2+). According to the accumulated data the designed motifs exhibit higher biological activities than the reference compounds. More... »

PAGES

2628-2645

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070363218120265

DOI

http://dx.doi.org/10.1134/s1070363218120265

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113042192


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