Unexpected Reaction of Ethyl 4-(Chloromethyl)pyrazolo- [5,1-c][1,2,4]triazine-3-carboxylates with Thiourea and Its Mechanism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01

AUTHORS

I. V. Ledenyova, A. V. Falaleev, Kh. S. Shikhaliev, E. A. Ryzhkova, F. I. Zubkov

ABSTRACT

The reaction of ethyl 4-(chloromethyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylates with thiourea in dimethylformamide involves ANRORC rearrangement (Addition of the Nucleophile, Ring Opening, and Ring Closure) followed by N-formylation to give N-{5-(4-oxo-8-phenyl-1,4-dihydropyrazolo[5,1-c][1,2,4]-triazin-3-yl)-1,3-triazol-2-yl}formamides whose structure was confirmed by X-ray analysis. The reaction mechanism has been studied by HPLC/MS.

PAGES

73-79

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070363218010115

DOI

http://dx.doi.org/10.1134/s1070363218010115

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101346687


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