Reactions of hydroxyphenyl-substituted 1,2,4-triazoles with electrophylic reagents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

E. Yu. Shasheva, N. I. Vikrishchuk, L. D. Popov, A. D. Vikrishchuk, I. E. Mikhailov, K. A. Lysenko, M. E. Kletskii

ABSTRACT

Reactions of hydroxyphenyl substituted 1,2,4-triazoles with various electrophylic reagents were studied. Despite of the presence of several nucleophilic centers in the molecule, the reactions were shown to proceed regioselectively, with the formation of N-substituted 3-(2-hydroxyphenyl)-1,2,4-triazoles. As a result of the reactions of alkylation, tosylation, sulfoamination and aminomethylation by Mannich reaction earlier unknown potential biologically active N-derivatives of 1,2,4-triazole were obtained. More... »

PAGES

2234

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070363209100259

DOI

http://dx.doi.org/10.1134/s1070363209100259

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023595207


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