Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

A. G. Balya, A. N. Chernega, S. A. But, A. N. Vasilenko, V. S. Brovarets, B. S. Drach

ABSTRACT

N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

PAGES

1427-1435

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1070363208070268

DOI

http://dx.doi.org/10.1134/s1070363208070268

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010788947


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