Guanidines based on tryptamine and histamine in reactions with electrophiles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

A. S. Shestakov, O. E. Sidorenko, Kh. S. Shikhaliev, A. A. Pavlenko

ABSTRACT

Reactions of 4,6-dimethylpyrimidin-2-ylcyanamide with tryptamines and histamine gave the corresponding disubstituted guanidines. The molecular parameters of the products were calculated using GAUSSIAN 03 software package. The direction of electrophilic attack on these compounds was predicted on the basis of the geometric shape of their highest occupied molecular orbital (HOMO) and molecular electrostatic potential (MEP) maps. Acyl, carbamoyl, and cyclic derivatives were obtained, whose structure was consistent with the results of quantum-chemical calculations. More... »

PAGES

1749-1760

References to SciGraph publications

  • 2005-02. Arylbiguanides in Heterocyclization Reactions in RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • 2004-10. Synthesis and chemical transformations of mono- and disubstituted cyanamides in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • 2006-10. Reaction of cyanamides with N,N-binucleophiles in RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1134/s1070363207100143

    DOI

    http://dx.doi.org/10.1134/s1070363207100143

    DIMENSIONS

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