A new 2-(4H-1,3-benzoxazin-4-on-2-yl)-1,3-tropolone: Synthesis, structure, and antibacterial properties View Full Text


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Article Info

DATE

2016-03

AUTHORS

Yu. A. Sayapin, E. A. Gusakov, I. V. Dorogan, I. O. Tupaeva, M. G. Teimurazov, N. K. Fursova, K. V. Ovchinnikov, V. I. Minkin

ABSTRACT

2-(4H-1,3-Benzoxazin-4-on-2-yl)-4,5,6-trichloro-1,3-tropolone, structural properties of which were studied using 1H NMR, IR-spectroscopy, mass spectrometry, and quantum chemistry has been obtained for the first time using an acid-catalyzed condensation reaction of 3,4,5,6-tetrachloro-1,2-benzoquinone with 2-methyl-4H-3,1-benzoxazin-4-one. It has been shown that the new tropolone possesses antibacterial activity against hospital-acquired strains of gram-negative (Escherichia coli, Salmonella enterica sv. Enteritidis, Acinetobacter baumannii, and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria. The obtained substance is suggested for development of a new antibacterial drug. More... »

PAGES

224-228

References to SciGraph publications

  • 2014-06. Synthesis and structure of 2-(4′-oxo-3H-quinazolin-2′-yl)-1,3-tropolone in RUSSIAN CHEMICAL BULLETIN
  • 2014-05-08. New copper(II) 2-(alkylamino)troponates in TRANSITION METAL CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s1068162016020114

    DOI

    http://dx.doi.org/10.1134/s1068162016020114

    DIMENSIONS

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