Acetylcholinesterase inhibition activity of some quinolinyl substituted triazolothiadiazole derivatives View Full Text


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Article Info

DATE

2015-03-20

AUTHORS

Muhammad Rafiq, Muhammad Saleem, Muhammad Hanif, Qamar Abbas, Ki Hwan Lee, Sung-Yum Seo

ABSTRACT

A series of aralkanoic acids was converted into aralkanoic acid hydrazides through their esters formation. The aralkanoic acid hydrazides upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazinate salts, which on refluxing with aqueous hydrazine hydrate yielded 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles. The target compounds, 3-aralkyl-6-(substitutedquinolinyl) [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, were synthesized by condensing various quinolinyl substituted carboxylic acids with 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles in phosphorus oxychloride. The structures of the newly synthesized triazolothiadiazoles were characterized by IR, 1H NMR, 13C NMR, and elemental analysis studies. The structure of one of the 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles was unambiguously deduced by single crystal X-ray diffraction analysis. All the synthesized compounds were screened for their acetylcholinesterase inhibition activities. Four of the triazolothiadiazoles exhibited excellent acetylcholinesterase inhibition activities as compared to the reference inhibitor. More... »

PAGES

170-177

References to SciGraph publications

  • 2003-08. Acetylcholinesterase in JOURNAL OF MOLECULAR NEUROSCIENCE
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    http://scigraph.springernature.com/pub.10.1134/s1068162015020089

    DOI

    http://dx.doi.org/10.1134/s1068162015020089

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