Comparative evaluation of antimicrobial activity of oligochitosans against Klebsiella pneumoniae View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-22

AUTHORS

S. N. Kulikov, V. E. Tikhonov, E. A. Bezrodnykh, S. A. Lopatin, V. P. Varlamov

ABSTRACT

The Antibacterial activity of chitosan of different molecular weights was studied against gramnegative Klebsiella pneumoniae at different pH values. It was found that the dependence of the inhibitory activity of chitosan on its molecular weight was undergoes inversion when increasing the pH of the medium above 7.0. In acidic media, chitosan of the higher molecular weight had the higher antibacterial activity, while in weàk alkaline media, oligomeric forms of chitosan displayed only the inhibition effect. Our results showed that the antibacterial activity of chitosan against Klebsiella pneumoniae was closely associated with its polycationic nature, and depended on the degree of protonation of the chitosan amino groups, which, in turn was the function of the degree of polymerization and the pH values of the medium. The results allow one to explain, in part, the contradictory literature data concerning the relationship between the antibacterial activity and molecular weight of chitosan. More... »

PAGES

57-62

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1068162015010100

DOI

http://dx.doi.org/10.1134/s1068162015010100

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021895678


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biochemistry and Metabolomics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kazan Federal University, Kazan, Russia", 
          "id": "http://www.grid.ac/institutes/grid.77268.3c", 
          "name": [
            "Kazan Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, ul. Bolshaya Krasnaya 67, 420015, Kazan, Russia", 
            "Kazan Federal University, Kazan, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kulikov", 
        "givenName": "S. N.", 
        "id": "sg:person.0647512277.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647512277.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.431939.5", 
          "name": [
            "Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tikhonov", 
        "givenName": "V. E.", 
        "id": "sg:person.0721021205.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721021205.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.431939.5", 
          "name": [
            "Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bezrodnykh", 
        "givenName": "E. A.", 
        "id": "sg:person.0604572605.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604572605.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.482762.d", 
          "name": [
            "Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopatin", 
        "givenName": "S. A.", 
        "id": "sg:person.01340512010.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340512010.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.482762.d", 
          "name": [
            "Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varlamov", 
        "givenName": "V. P.", 
        "id": "sg:person.0631556207.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631556207.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10517-005-0489-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022706293", 
          "https://doi.org/10.1007/s10517-005-0489-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00299352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040048101", 
          "https://doi.org/10.1007/bf00299352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s1061934809060197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010476203", 
          "https://doi.org/10.1134/s1061934809060197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:abim.0000025947.84650.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007843646", 
          "https://doi.org/10.1023/b:abim.0000025947.84650.b4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01-22", 
    "datePublishedReg": "2015-01-22", 
    "description": "The Antibacterial activity of chitosan of different molecular weights was studied against gramnegative Klebsiella pneumoniae at different pH values. It was found that the dependence of the inhibitory activity of chitosan on its molecular weight was undergoes inversion when increasing the pH of the medium above 7.0. In acidic media, chitosan of the higher molecular weight had the higher antibacterial activity, while in we\u00e0k alkaline media, oligomeric forms of chitosan displayed only the inhibition effect. Our results showed that the antibacterial activity of chitosan against Klebsiella pneumoniae was closely associated with its polycationic nature, and depended on the degree of protonation of the chitosan amino groups, which, in turn was the function of the degree of polymerization and the pH values of the medium. The results allow one to explain, in part, the contradictory literature data concerning the relationship between the antibacterial activity and molecular weight of chitosan.", 
    "genre": "article", 
    "id": "sg:pub.10.1134/s1068162015010100", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1087149", 
        "issn": [
          "1068-1620", 
          "1608-330X"
        ], 
        "name": "Russian Journal of Bioorganic Chemistry", 
        "publisher": "Pleiades Publishing", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "keywords": [
      "Klebsiella pneumoniae", 
      "antibacterial activity", 
      "pneumoniae", 
      "inhibitory activity", 
      "contradictory literature data", 
      "high antibacterial activity", 
      "activity", 
      "weight", 
      "comparative evaluation", 
      "antimicrobial activity", 
      "molecular weight", 
      "inhibition effect", 
      "group", 
      "oligomeric forms", 
      "polycationic nature", 
      "evaluation", 
      "degree", 
      "effect", 
      "results", 
      "function", 
      "literature data", 
      "high molecular weight", 
      "values", 
      "data", 
      "medium", 
      "relationship", 
      "oligochitosan", 
      "different molecular weights", 
      "part", 
      "form", 
      "chitosan", 
      "amino groups", 
      "turn", 
      "pH", 
      "nature", 
      "pH value", 
      "chitosan amino groups", 
      "dependence", 
      "degree of polymerization", 
      "degree of protonation", 
      "inversion", 
      "acidic medium", 
      "polymerization", 
      "alkaline medium", 
      "protonation"
    ], 
    "name": "Comparative evaluation of antimicrobial activity of oligochitosans against Klebsiella pneumoniae", 
    "pagination": "57-62", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021895678"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1134/s1068162015010100"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1134/s1068162015010100", 
      "https://app.dimensions.ai/details/publication/pub.1021895678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_668.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1134/s1068162015010100"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s1068162015010100'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s1068162015010100'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s1068162015010100'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s1068162015010100'


 

This table displays all metadata directly associated to this object as RDF triples.

153 TRIPLES      21 PREDICATES      73 URIs      61 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1134/s1068162015010100 schema:about anzsrc-for:11
2 anzsrc-for:1101
3 schema:author Ne218b69b84134687a7ac845304911687
4 schema:citation sg:pub.10.1007/bf00299352
5 sg:pub.10.1007/s10517-005-0489-6
6 sg:pub.10.1023/b:abim.0000025947.84650.b4
7 sg:pub.10.1134/s1061934809060197
8 schema:datePublished 2015-01-22
9 schema:datePublishedReg 2015-01-22
10 schema:description The Antibacterial activity of chitosan of different molecular weights was studied against gramnegative Klebsiella pneumoniae at different pH values. It was found that the dependence of the inhibitory activity of chitosan on its molecular weight was undergoes inversion when increasing the pH of the medium above 7.0. In acidic media, chitosan of the higher molecular weight had the higher antibacterial activity, while in weàk alkaline media, oligomeric forms of chitosan displayed only the inhibition effect. Our results showed that the antibacterial activity of chitosan against Klebsiella pneumoniae was closely associated with its polycationic nature, and depended on the degree of protonation of the chitosan amino groups, which, in turn was the function of the degree of polymerization and the pH values of the medium. The results allow one to explain, in part, the contradictory literature data concerning the relationship between the antibacterial activity and molecular weight of chitosan.
11 schema:genre article
12 schema:isAccessibleForFree false
13 schema:isPartOf Nb56031e75fe14daf9ea7e2853a414334
14 Nca40641de2984be89527c5887dfbe154
15 sg:journal.1087149
16 schema:keywords Klebsiella pneumoniae
17 acidic medium
18 activity
19 alkaline medium
20 amino groups
21 antibacterial activity
22 antimicrobial activity
23 chitosan
24 chitosan amino groups
25 comparative evaluation
26 contradictory literature data
27 data
28 degree
29 degree of polymerization
30 degree of protonation
31 dependence
32 different molecular weights
33 effect
34 evaluation
35 form
36 function
37 group
38 high antibacterial activity
39 high molecular weight
40 inhibition effect
41 inhibitory activity
42 inversion
43 literature data
44 medium
45 molecular weight
46 nature
47 oligochitosan
48 oligomeric forms
49 pH
50 pH value
51 part
52 pneumoniae
53 polycationic nature
54 polymerization
55 protonation
56 relationship
57 results
58 turn
59 values
60 weight
61 schema:name Comparative evaluation of antimicrobial activity of oligochitosans against Klebsiella pneumoniae
62 schema:pagination 57-62
63 schema:productId N486c678ca33c4be385ea340bc299af68
64 N8f51eab8ba00490dbbab5bbfebaf28be
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021895678
66 https://doi.org/10.1134/s1068162015010100
67 schema:sdDatePublished 2022-10-01T06:40
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nb44fc7c876124d99947dd791c36a988a
70 schema:url https://doi.org/10.1134/s1068162015010100
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N486c678ca33c4be385ea340bc299af68 schema:name doi
75 schema:value 10.1134/s1068162015010100
76 rdf:type schema:PropertyValue
77 N8f51eab8ba00490dbbab5bbfebaf28be schema:name dimensions_id
78 schema:value pub.1021895678
79 rdf:type schema:PropertyValue
80 Nb44fc7c876124d99947dd791c36a988a schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 Nb56031e75fe14daf9ea7e2853a414334 schema:volumeNumber 41
83 rdf:type schema:PublicationVolume
84 Nc43bef795523462991972bb5b2016371 rdf:first sg:person.0721021205.77
85 rdf:rest Ncc370445212b4494b82649f5e48e5433
86 Nc9b16d65687c45fdb17db21ca9f68365 rdf:first sg:person.0631556207.02
87 rdf:rest rdf:nil
88 Nca40641de2984be89527c5887dfbe154 schema:issueNumber 1
89 rdf:type schema:PublicationIssue
90 Ncb1c81e6fa8842e6af7195c2ec96e7a7 rdf:first sg:person.01340512010.16
91 rdf:rest Nc9b16d65687c45fdb17db21ca9f68365
92 Ncc370445212b4494b82649f5e48e5433 rdf:first sg:person.0604572605.32
93 rdf:rest Ncb1c81e6fa8842e6af7195c2ec96e7a7
94 Ne218b69b84134687a7ac845304911687 rdf:first sg:person.0647512277.34
95 rdf:rest Nc43bef795523462991972bb5b2016371
96 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
97 schema:name Medical and Health Sciences
98 rdf:type schema:DefinedTerm
99 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
100 schema:name Medical Biochemistry and Metabolomics
101 rdf:type schema:DefinedTerm
102 sg:journal.1087149 schema:issn 1068-1620
103 1608-330X
104 schema:name Russian Journal of Bioorganic Chemistry
105 schema:publisher Pleiades Publishing
106 rdf:type schema:Periodical
107 sg:person.01340512010.16 schema:affiliation grid-institutes:grid.482762.d
108 schema:familyName Lopatin
109 schema:givenName S. A.
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340512010.16
111 rdf:type schema:Person
112 sg:person.0604572605.32 schema:affiliation grid-institutes:grid.431939.5
113 schema:familyName Bezrodnykh
114 schema:givenName E. A.
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604572605.32
116 rdf:type schema:Person
117 sg:person.0631556207.02 schema:affiliation grid-institutes:grid.482762.d
118 schema:familyName Varlamov
119 schema:givenName V. P.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631556207.02
121 rdf:type schema:Person
122 sg:person.0647512277.34 schema:affiliation grid-institutes:grid.77268.3c
123 schema:familyName Kulikov
124 schema:givenName S. N.
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647512277.34
126 rdf:type schema:Person
127 sg:person.0721021205.77 schema:affiliation grid-institutes:grid.431939.5
128 schema:familyName Tikhonov
129 schema:givenName V. E.
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721021205.77
131 rdf:type schema:Person
132 sg:pub.10.1007/bf00299352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040048101
133 https://doi.org/10.1007/bf00299352
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/s10517-005-0489-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022706293
136 https://doi.org/10.1007/s10517-005-0489-6
137 rdf:type schema:CreativeWork
138 sg:pub.10.1023/b:abim.0000025947.84650.b4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007843646
139 https://doi.org/10.1023/b:abim.0000025947.84650.b4
140 rdf:type schema:CreativeWork
141 sg:pub.10.1134/s1061934809060197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010476203
142 https://doi.org/10.1134/s1061934809060197
143 rdf:type schema:CreativeWork
144 grid-institutes:grid.431939.5 schema:alternateName Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia
145 schema:name Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia
146 rdf:type schema:Organization
147 grid-institutes:grid.482762.d schema:alternateName Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia
148 schema:name Bioengineering Center of the Russian Academy of Sciences, Moscow, Russia
149 rdf:type schema:Organization
150 grid-institutes:grid.77268.3c schema:alternateName Kazan Federal University, Kazan, Russia
151 schema:name Kazan Federal University, Kazan, Russia
152 Kazan Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, ul. Bolshaya Krasnaya 67, 420015, Kazan, Russia
153 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...