Betulonic amides modified at cycle a by amino acids: Synthesis and inhibition of flu A virus reproduction View Full Text


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Article Info

DATE

2009-01

AUTHORS

O. B. Flekhter, N. I. Medvedeva, G. A. Tolstikov, O. V. Savinova, E. I. Boreko, F. M. Dolgushin

ABSTRACT

The Beckman rearrangement of carboxy- and alkyloxycarbonylalkylamides of 3-hydroxyiminobetulonic acid led to derivatives of 3a-homo-4-aza-3-oxolup-20(29)-ene and 3,4-seco-2-cyanolupa-4(23),20(29)-diene. An X-ray analysis showed methyl 3-(N-acetoximino)lup-20(29)-enoate is the E-isomer. The compounds synthesized exhibited inhibiting activity toward the reproduction of flu A virus in cell culture.

PAGES

118-122

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1068162009010154

DOI

http://dx.doi.org/10.1134/s1068162009010154

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050126775


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