Preparation of androsta-1,4-diene-3,17-dione from sterols using Mycobacterium neoaurum VKPM Ac-1656 strain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

M. A. Molchanova, V. A. Andryushina, T. S. Savinova, T. S. Stytsenko, N. V. Rodina, N. E. Voishvillo

ABSTRACT

A product of microbiological cleavage of the sterols side chain, androsta-1,4-diene-3,17-dione, is toxic for bacteria, in particular, actinobacteria of the genera Mycobacterium and Arthrobacter. Sterols were transformed into androsta-1,4-diene-3,17-dione by culturing the M. neoaurum VKPM Ac-1656 strain in a high yield, provided that a sorbent was used for elimination of contact between the bacterial cells and the product. Unlike the cholesterol side chain, the more branched chains of phytosterols were cleaved in the presence of M. neoaurum at a high rate only under turbulent stirring of the culture medium, which intensified the formation of hydrocarbonate ion from NaNI3 in situ. More... »

PAGES

354-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1068162007030132

DOI

http://dx.doi.org/10.1134/s1068162007030132

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048268884


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