New conjugates of antitumor antibiotic doxorubicin with water-soluble galactomannan: Synthesis and biological activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

A. N. Tevyashova, E. N. Olsufyeva, M. N. Preobrazhenskaya, A. A. Klyosov, E. Zomer, D. Platt

ABSTRACT

New water-soluble conjugates in the form of Schiff bases (DGM-1 and DGM-2) were prepared by the interaction of water-soluble periodate-oxidized galactomannan with doxorubicin or N-(L-lysyl)doxorubicin, respectively. The water-soluble galactomannan (DAVANAT®, a commercial product of Pro-Pharmaceuticals company) was obtained by partial acidic hydrolysis of high-molecular-mass galactomannan from Cyamopsis tetragonoloba (guar gum) seeds. The conjugate stability was studied in aqueous solutions. The DGM-1 anti-proliferative activity was comparable with that of doxorubicin on three models: cell lines of murine melanoma B16-F1 and human breast cancer MCF-7 (HTB-22) and human colon cancer HT-29 (HTB-38). DGM-2 was poorly active in all the three tests. DGM-1 can thus be regarded as a high-molecular-mass depot form of doxorubicin. More... »

PAGES

139-145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1068162007010153

DOI

http://dx.doi.org/10.1134/s1068162007010153

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046140130


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