Preclinical Evaluation of Radioiodinated Quinoxaline Derivative as a Possible Brain Imaging Agent View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

I. T. Ibrahim, H. M. Talaat, R. A. Ayad, K. Farah

ABSTRACT

4-{(4-Methylphenyl)glycyl}-3,4-dihydroquinoxalin-2(1H)-one (QIN) was prepared from 4-(2-chloroacetyl)- 3,4-dihydroquinoxalin-1(1H)-one). 125I-QIN was prepared by electrophilic substitution using Chloramine- T as an oxidizing agent. The highest labeling yield, 94%, was obtained under the following conditions: pH 7, 15 min, 100 μg of QIN, 50 μg of Chloramine-T, and carrier-free Na125I. The labeled compound was stable for up to 12 h post labeling. A biodistribution study of 125I-QIN in mice showed that its brain uptake was about 5.1% at 30 min post injection and remained on this level up to 1 h. As compared to commercially used radiopharmaceuticals for brain imaging, 125I-QIN is more stable and shows higher brain uptake. More... »

PAGES

638-643

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1066362218060127

DOI

http://dx.doi.org/10.1134/s1066362218060127

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110910889


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