Crystal Structure and Physicochemical Characteristics of Two Novel Adamantane Derivatives of Sulfonamides View Full Text


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Article Info

DATE

2021-05-25

AUTHORS

O. V. Kovalchukova, V. P. Kazachenko, V. V. Tkachev, A. N. Utenyshev, N. N. Strakhova, A. N. Proshin

ABSTRACT

Two derivatives of adamantane benzenesulfamide have been synthesized and studied: N-adamantane-1-yl-2,4,6-trimethyl-benzenesulfamide (1) and N-adamantane-1-yl-4-methoxy-benzenesulfamide (2). Crystal structures 1 and 2 are solved using X-ray diffraction (XRD) analysis. The solubilities of compounds in a phosphate buffer solution with pH 7.4, 1-octanol, and n-hexane are determined at several temperature points using isothermal saturation. The values of Gibbs energy, enthalpy, and entropy of solubility of the compounds at 298 K are determined. More... »

PAGES

424-428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1063774521030123

DOI

http://dx.doi.org/10.1134/s1063774521030123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138338390


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