Study of physicochemical and biological properties of calcium phosphate coatings prepared by RF magnetron sputtering of silicon-substituted hydroxyapatite View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-08

AUTHORS

V. F. Pichugin, M. A. Surmeneva, R. A. Surmenev, I. A. Khlusov, M. Epple

ABSTRACT

Coatings based on pure silicon and silicon-substituted hydroxyapatite were grown by RF magnetron sputtering. The coating surface morphology, phase and elemental composition were studied by scanning electron microscopy, energy-dispersive X-ray analysis, and infrared spectroscopy. It was found that coatings are X-ray-amorphous, their elemental composition being controlled by the sputtered target composition. The distribution of elements over the coating surface is homogeneous. Medical and biological properties of coatings were studied in vivo and in vitro. Osteogenic properties of coatings were studied. Coatings grown by sputtering of a stoichiometric hydroxyapatite target are biocompatible without osteoinductive activity. The introduction of silicate ions into the hydroxyapatite structure that forms an electrode target significantly enhances the in vivo effect of CaP magnetron coatings on the osteogenic activity and stromal bone-marrow stem cells. More... »

PAGES

863

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1027451011090138

DOI

http://dx.doi.org/10.1134/s1027451011090138

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022952905


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