The Correlation of MTHFR SNPs, Homocysteine, and Conventional Risk Predictors with Coronary Artery Disease View Full Text


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Article Info

DATE

2021-11-18

AUTHORS

R. Masud, A. U. H. Khan, H. Z. Baqai, A. Iqbal

ABSTRACT

Arterial thromboembolic disease affects coronary vasculature and has an exhaustive list of etiologies. The aim of the present study was to investigate the effects of genetic variants in homocysteine pathway genes, homocysteine levels, and other modifiable and non-modifiable conventionally allotted risk factors for coronary artery disease. Study was retrospective case control study, comprised 404 participants (controls, n = 179, ischemic heart disease (IHD) patients, n = 89, and myocardial infarction (MI) cases, n = 136, respectively). Single nucleotide polymorphisms (SNPs); rs1801133, rs1801131 in methylenetetrahydrofolate reductase ‘MTHFR’ gene, rs1805087 in methyl tetrahydrofolate homocysteine methyltransferase ‘MTR’ gene, and rs662 in paroxanse1 ‘PON1’ gene, rs4646994, angiotensin converting enzyme ‘ACE’ insertion/deletion (I/D) polymorphism were resolved employing conventional, and by tetra primer allele refractory mutation system polymerase chain reaction (PCR). ANOVA association testing revealed that homocysteine, cholesterol, creatinine, triglyceride levels, age, family history of CAD, and polymorphisms in MTHFR and PON1 related to coronary artery disease. The post HOC analysis also maintained significance differences in the control, ischemic heart disease and case groups respectively. The regression analysis failed to maintain statistical significance for creatinine, triglycerides, age, and rs662 PON1 polymorphism, whereby, serum homocysteine, cholesterol, family history, and rs1801133/rs1801131 MTHFR SNPs maintained statistical significance. The results from the present study provide hint into interlaced nature of traditional and novel risk factors in the causation of arterial disease and an insight into their shared detrimental effects in affecting the coronary vasculature. More... »

PAGES

1328-1336

References to SciGraph publications

  • 2020-07-18. Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD) in BMC CARDIOVASCULAR DISORDERS
  • 2017-12-15. The proper use of coronary calcium score and coronary computed tomography angiography for screening asymptomatic patients with cardiovascular risk factors in SCIENTIFIC REPORTS
  • 2018-09-27. Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects in LIPIDS IN HEALTH AND DISEASE
  • 2020-03-26. Coronary Artery Disease: From Mechanism to Clinical Practice in CORONARY ARTERY DISEASE: THERAPEUTICS AND DRUG DISCOVERY
  • 2008-01-19. Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease in JOURNAL OF THROMBOSIS AND THROMBOLYSIS
  • 2013-07-17. Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease in CARDIOVASCULAR DIABETOLOGY
  • 2011-05-13. Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2019-06-24. Metabolomics study in severe extracranial carotid artery stenosis in BMC NEUROLOGY
  • 2002-05. Cardiovascular Risk in Patients with Early Renal Insufficiency in AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
  • 2013-04-27. The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2020-02-20. Coronary plaque tissue characterization in patients with premature coronary artery disease in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
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