Features of the Genomic Distribution of Runs of Homozygosity in the Indigenous Population of Northern Eurasia at the Individual and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-18

AUTHORS

N. A. Kolesnikov, V. N. Kharkov, A. A. Zarubin, M. O. Radzhabov, M. I. Voevoda, M. A. Gubina, E. K. Khusnutdinova, S. S. Litvinov, N. V. Ekomasova, O. V. Shtygasheva, N. R. Maksimova, A. L. Sukhomyasova, V. A. Stepanov

ABSTRACT

The genomic data analysis (~886 889 autosomal SNPs) allowed us to estimate the inbreeding level on the basis of the analysis of runs of homozygosity (FROH) in a sample of 1836 individuals, including 76 indigenous populations of Siberia, Dagestan, the Caucasus, Volga-Ural region, Eastern Europe, and Central Asia. The data were obtained using the Infinium Multi-Ethnic Global-8 Kit. In the populations of Dagestan, within the Nakh-Daghestanian language family, representatives of several language groups can be distinguished, with the maximum FROH level for the Dido group (0.0727) and the Andean group (0.0378), which is similar in values to the populations speaking the Chukchi-Kamchatka and Nivkh languages of Siberia (0.0360). The Siberian populations are characterized by a greater value of the total length of short and medium runs of homozygosity per person. The total length of long ROHs is more variable and much larger in the most of the populations of Dagestan and Siberia compared to other populations of the Caucasus, Central Asia, Europe, and the Volga-Ural region. More... »

PAGES

1271-1284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1022795421110053

DOI

http://dx.doi.org/10.1134/s1022795421110053

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142689599


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