Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Andrey A. Gorchakov, Artyom A. Alekseyenko, Peter V. Kharchenko, Peter J. Park, Mitzi I. Kuroda

ABSTRACT

For the dosage compensation to occur, genes on the single male X chromosomes in Drosophila must be selectively bound and acetylated by the ribonucleoprotein complex called MSL complex. It remained unknown how such exquisite specificity is achieved, and whether specific DNA sequences were involved. In the present work we demonstrate that it is transcription of the gene on the X chromosome that is important for MSL targeting, irrespective of gene origin and DNA sequence. More... »

PAGES

1263-1266

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1022795410100303

DOI

http://dx.doi.org/10.1134/s1022795410100303

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048087247


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