Polycomb and Trithorax control genome expression by determining the alternative chromatin epigenetic states for key developmental regulators View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Yu. B. Schwartz, T. G. Kahn, V. Pirrotta

ABSTRACT

The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genomic analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes. More... »

PAGES

1247-1249

Journal

TITLE

Russian Journal of Genetics

ISSUE

10

VOLUME

46

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s1022795410100261

DOI

http://dx.doi.org/10.1134/s1022795410100261

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031981962


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